Effect of Liposomal Delivery of Oxidized Dextran with Isonicotinic Acid Hydrazide on Component Profile of Pulmonary Extracellular Matrix in Mice with BCG-Induced Granulomatosis

Kim, L. B.; Putyatina, A. N.; Russkikh, G. S.; Shkurupy, V. A.

doi:10.1007/s10517-019-04687-7

Cited by 3 publications

(1 citation statement)

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“…The evidence of inhibition of pulmonary fibrosis in TB by OD is based on the results of reducing the number of adhesions in the abdominal cavity and the volume density of collagen in them [124], as well as reducing the content of protein-bound hydroxyproline and total GAG in blood serum in a model of adhesive disease in rats [125]. The data on the effectiveness of LEDZ in mice are presented below, depending on the method of administration and the stage of the TB process.…”

Section: Ledzmentioning

confidence: 99%

Mechanism of lungs fibrosis in mycobacterial infection

Kim,

Putyatina

2023

Exploration of Medicine

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Lung tuberculosis (TB) remains a heavy burden on public health worldwide. This review discusses mainly the mechanisms of the development of pulmonary fibrosis in an experimental TB model in mice. The involvement of individual components of the extracellular matrix, the activity of matrix metalloproteinases, and the role of their tissue inhibitors in the fibrosis development. The current TB therapy activates fibrosis along with anti-mycobacterial action. The paper describes the authors’ results of experimental use of the liposome-encapsulated dextrazid (LЕDZ) combined with isoniazid (INH) which has both antifibrotic and anti-mycobacterial effects to be considered for future treatment.

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Section: Ledzmentioning

confidence: 99%