Effect of liquorice (root extract) mouth rinse on dental plaque and gingivitis – A randomized controlled clinical trial

Sharma, Sakshi; Sogi, GM; Saini, Vipin; Chakraborty, Tulshi; Sudan, Jasneet

doi:10.4103/jisp.jisp_517_20

Cited by 7 publications

(5 citation statements)

References 20 publications

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“…In addition, the results of Jabbari Ghanati et al (2018) showed that after four days of intervention in the chlorhexidine group, oral health improved significantly compared to that before the intervention [ 8 ]. The results of the present study are also consistent with the results of Safarabadi et al (2012) [ 22 ], Desai et al (2023) [ 24 ], and Jain et al (2017) [ 19 ]. In contrast to the present study, Goltashin et al showed that glycyrrhizin added to toothpaste had no effect on the plaque index or gingival index [ 25 ].…”

Section: Discussionsupporting

confidence: 93%

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Comparison of the effect of licorice and chlorhexidine mouthwash on the oral health of intubated patients in the intensive care unit

Oshvandi,

Lotfi,

Azizi

et al. 2024

BMC Oral Health

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Background Chlorhexidine mouthwash is a common oral hygiene product used in intensive care units, but it may have some adverse effects. Licorice, a natural herb, could be a potential alternative to chlorhexidine. However, the effect of licorice mouthwash on the oral health of intubated patients has not been studied yet. Therefore, this study aimed to compare the effects of licorice and chlorhexidine mouthwash on the oral health of intubated patients. Methods This was a triple-blind clinical trial. The sample included 130 intubated patients admitted to an intensive care unit in Iran. The samples were selected by convenience sampling and randomly assigned to two groups: A and B. In group A, the main researcher applied 15 ml of 0.2% chlorhexidine mouthwash after each brushing (twice a day for 5.5 days) and suctioned it after 30 s. In group B, 20% licorice mouthwash was used instead of chlorhexidine. The demographic information questionnaire and the Beck Oral Assessment Scale (BOAS) were completed by one of the nurses before and on the sixth day of the study. Results Finally, 60 patients in each group completed the study. There was no significant difference between the groups in terms of demographic variables or oral health before the intervention (P > 0.05). The oral health of patients in both the chlorhexidine and liquorice mouthwash groups improved significantly after the intervention (P < 0.05). However, there was no significant difference in oral health between the two groups at postintervention (P = 0.06). Conclusion The results demonstrated that both mouthwashes exerted a comparable effect on dental and oral health. However, the chlorhexidine mouthwash showed a greater impact on the reduction of dental plaque and the thinning of saliva compared to licorice mouthwash. In essential cases, licorice mouthwash can be employed as an alternative to chlorhexidine.

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Section: Discussionsupporting

confidence: 93%

“…This finding is consistent with the study of Desai et al (2023), who concluded that liquorice mouthwash can be substituted for chlorhexidine mouthwash [ 24 ]. Although the variables measured and the tools used in the studies differed, the results were similar to those of the present study.…”

Section: Discussionsupporting

confidence: 93%

Comparison of the effect of licorice and chlorhexidine mouthwash on the oral health of intubated patients in the intensive care unit

Oshvandi,

Lotfi,

Azizi

et al. 2024

BMC Oral Health

View full text Add to dashboard Cite

show abstract

“…This nding is consistent with the study of Desai et al (2023), who concluded that liquorice mouthwash can be substituted for chlorhexidine mouthwash [21]. Although the variables measured and the tools used in the studies differed, the results were similar to those of the present study.…”

Section: Discussionsupporting

confidence: 93%

“…[8]. The results of the present study are also consistent with the results ofSafarabadi et al (2012) [19],Desai et al (2023) [21], and Jain et al…”

supporting

confidence: 93%

Comparison of the effect of licorice and chlorhexidine mouthwash on the oral health of intubated patients in the intensive care unit

Oshvandi,

Lotfi,

Azizi

et al. 2024

Preprint

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Background Chlorhexidine mouthwash is a common oral hygiene product used in intensive care units, but it may have some adverse effects. Licorice, a natural herb, could be a potential alternative to chlorhexidine. However, the effect of licorice mouthwash on the oral health of intubated patients has not been studied yet. Therefore, this study aimed to compare the effects of licorice and chlorhexidine mouthwash on the oral health of intubated patients. Methods This was a triple-blind clinical trial. The sample included 130 intubated patients admitted to an intensive care unit in Iran. The samples were selected by convenience sampling and randomly assigned to two groups: A and B. In group A, the main researcher applied 15 ml of 0.2% chlorhexidine mouthwash after each brushing (twice a day for 5.5 days) and suctioned it after 30 seconds. In group B, 20% licorice mouthwash was used instead of chlorhexidine. The demographic information questionnaire and the Beck Oral Assessment Scale (BOAS) were completed by one of the nurses before and on the sixth day of the study. Results Finally, 60 patients in each group completed the study. There was no significant difference between the groups in terms of demographic variables or oral health before the intervention (P > 0.05). The oral health of patients in both the chlorhexidine and liquorice mouthwash groups improved significantly after the intervention (P < 0.05). However, there was no significant difference in oral health between the two groups at postintervention (P = 0.06). Conclusion Considering the herbal nature, cost-effectiveness and lack of serious side effects of licorice mouthwash, it can be used as a suitable alternative for chlorhexidine.

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“…Licorice extract demonstrated potent anti-inflammatory effects by inhibiting inflammatory cytokines [35,36]. A recent study has shown that licorice and chlorhexidine mouthwash both prevent plaque buildup and gingival irritation [37]. Since the chemical ingredients of mouthwashes commonly available on the market have many side effects with prolonged usage, herbal mouthwash has been a better alternative for self-care treatment.…”

Section: Periodontal Diseasementioning

confidence: 99%

The Power of Licorice (Radix glycyrrhizae) to Improve Oral Health: A Comprehensive Review of Its Pharmacological Properties and Clinical Implications

AlDehlawi,

Jazzar

2023

Healthcare

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Licorice (Radix glycyrrhizae) is a plant root extract widely used in various applications, including cosmetics, food supplements, and traditional medicine. It has a long history of medicinal use in different cultures due to its diverse pharmacological properties. Licorice has traditionally been used for treating gastrointestinal problems, respiratory infections, cough, bronchitis, arthritis, and skin conditions. In recent years, the potential therapeutic benefits of licorice for oral health have gained significant interest. This paper aims to provide a comprehensive review of the effects of licorice extracts and their bioactive components on common oral diseases such as dental caries, periodontitis, halitosis, candidiasis, and recurrent aphthous ulcers. The chemical composition of licorice has shown the presence of several bioactive compounds such as glycyrrhizin, glabridin, isoliquiritigenin (ISL), and licochalcone exhibiting various pharmacological activities, including anti-inflammatory, antimicrobial, antioxidative, and immunomodulatory effects. Interestingly, in certain patients, licorice has shown a promising potential to inhibit the spread of viruses, prevent biofilm formation, reduce inflammation, boost immune responses, alleviate pain, and exert antioxidative effects. In this review, we provide a brief overview of the current understanding of licorice’s therapeutic benefits in the treatment of oral ailments, emphasising its potential as an alternative treatment option for oral diseases. Further research is warranted to explore its efficacy, safety, and clinical applications using placebo-controlled clinical trials.

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Effect of liquorice (root extract) mouth rinse on dental plaque and gingivitis – A randomized controlled clinical trial

Cited by 7 publications

References 20 publications

Comparison of the effect of licorice and chlorhexidine mouthwash on the oral health of intubated patients in the intensive care unit

Comparison of the effect of licorice and chlorhexidine mouthwash on the oral health of intubated patients in the intensive care unit

Comparison of the effect of licorice and chlorhexidine mouthwash on the oral health of intubated patients in the intensive care unit

The Power of Licorice (Radix glycyrrhizae) to Improve Oral Health: A Comprehensive Review of Its Pharmacological Properties and Clinical Implications

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