No abstract

Objective: We conducted a well-designed prevalence study in a rural population of Haryana in Mullana rural area to find out the latest prevalence of essential hypertension, the prescription pattern of antihypertensive drugs and the associated risk of new onset of diabetes. Methods:A retrospective study was carried out on the patient data (2672 patients) from the years 2009 to 2013 at OPD of M. M. University hospital, Mullana to find the previous year's prevalence of different diseases, including essential hypertension, new onset of diabetes and associated risk factors, prescription pattern of antihypertensive drug therapy. Based on the above results, a prospective study was conducted from January 2015 to December 2016 and total 510 patients (270 essential hypertension and 240 essential hypertension with new onset of diabetes) and 270 normal individuals were recruited in the study. Results:The retrospective study, a total of 2672 patients' data was evaluated which showed 41.21% prevalence of essential hypertension, 11.83% new onset of diabetes in Essential hypertension patients and 15.87% diabetic patients. Antihypertensive monotherapy was prescribed to 59.85% patients and combination therapy to 40.15% patients while that of a prospective study showed 40.37% patients of monotherapy and 59.63% patients of combination therapy. The prospective study also showed that different anthropometric parameters were significantly associated with risk of hypertension and new onset of diabetes except for age and height. Conclusion:An increase in the prevalence of essential hypertension and associated risk factors was observed when compared with previous studies and retrospective study. It is clearly seen by the change in drug therapy pattern and different anthropometric parameters. Implementation of a large scale awareness program is needed to combat these metabolic diseases.

No abstract

No abstract

Because of the present pandemic researchers are seeking for phytocandidates that can inhibit or stop SARS-CoV-2. The main protease (Mpro) of SARS-CoV-2 and spike glycoprotein (S) are both suppressed by bioactive compounds found in plants that work by docking them together. The Mpro proteins 6LU7 (complex with an inhibitor N3) and 5C3N (space group C2221) were employed in docking research. PyRx and AutoDock Vina software were used as docking engine. 22 identified phytoconstituents were selected from IMPPAT, a manually curated database, on the basis of their antiviral effects. Docking studies showed that phytoconstituents β-amyrin (-8.4 kcal/mol), withaferin A (-8.3 kcal/mol), oleanolic acid (-7.8 kcal/mol), and patentiflorin A (-8.1 kcal/mol) had the best results against 5C3N Mpro protein whereas kuwanon L (-7.1 kcal/mol), β-amyrin (-6.9 kcal/mol), oleanolic acid (-6.8 kcal/mol), cucurbitacin D (-6.5 kcal/mol), and quercetin (-6.5 kcal/mol) against 6LU7 Mpro protein. All the compounds were examined for their ADMET characteristics using SwissDock. Present research reports that the phytoconstituents along with docking score will be helpful for future drug development against Covid-19.