Effect of local propolis irrigation in experimental periodontitis in rats on inflammatory markers (IL-1β and TNF-α) and oxidative stress

Ali, Khadeeja Mohammed; Saleh, Ziwar; Jalal, Jalal

doi:10.4103/ijdr.ijdr_909_19

Cited by 8 publications

(7 citation statements)

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“…Propolis extract exhibited remarkable anti-inflammatory activity compared to the LPS control. Our findings on anti-inflammatory activity of propolis are in agreement with previous studies ( Ali, Saleh, & Jalal, 2020 ). In addition, various concentrations of oral/throat spray (0.125, 0.25, and 0.5 mg/mL) showed significant reductions in LPS-induced NO production (56.10 ± 1.02, 63.03 ± 2.85, and 71.30 ± 1.66%, respectively).…”

Section: Resultssupporting

confidence: 94%

“…The anti-inflammatory activities of these essential oils have been documented in several studies. Previous studies demonstrated that Thymus vulgaris ( Abdelli et al, 2017 ), Salvia officinalis ( Abu-Darwish et al, 2013 ), Mentha piperita ( Hejna, Kovanda, Rossi, & Liu, 2021 ), Pelargonium graveolens ( Ali, Saleh, & Jalal, 2020 ), Citrus lemon ( Shen, Jiang, Zhu, & Ou-Yang, 2017 ), and Nigella sativa ( Bordoni et al, 2019 ) essential oils exhibited anti-inflammatory effects via different mechanisms and pathways. Propolis extract exhibited remarkable anti-inflammatory activity compared to the LPS control.…”

Section: Resultsmentioning

confidence: 99%

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Development of propolis and essential oils containing oral/throat spray formulation against SARS-CoV-2 infection

Pelvan

Serhatlı

Karaoğlu

et al. 2022

Journal of Functional Foods

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Section: Resultssupporting

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Development of propolis and essential oils containing oral/throat spray formulation against SARS-CoV-2 infection

Pelvan

Serhatlı

Karaoğlu

et al. 2022

Journal of Functional Foods

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“…19,20,21 These findings are similar to those of Khadeeja M Ali et al, who show that administration inhibited proinflammation production, enhanced anti-inflammatory markers IL-1β and TNF-α, and oxidative stress minimized the increase in the level in experimental animal models. 22 Clinical studies performed by several researchers have demonstrated the application of medicinal plants to accelerate the healing process with antiinflammatory effects by their bioactivity abilities to promote wound healing and prevent infection without grave side effects. 23,24,25,26 According to another study, cinnamaldehyde effectively inhibited ox-LDL-induced vascular smooth muscle cells (VSMCs) proliferation, migration, and inflammatory cytokine overproduction, as well as foam cell formation in VSMCs and macrophages.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of natural lip balm cinnamon (Cinnamomum burmannii) in accelerating the incision wound healing process in rattus norvegicus

2022

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Introduction: Cinnamomum burmannii is commonly used in the treatment and is thought to be an anti-inflammation medicinal herb that may hasten recovery. Lip wound healing is a critical need for aesthetic performance. The purpose of this study is to evaluate the efficacy of natural lip balm C. Burmannii has been shown to speed up the healing of incision wounds in rats (Rattus norvegicus). Methods: This research was carried out in the laboratory biomedical Faculty of Medicine, Universitas Islam Bandung. In twenty-seven male rats weighing 200-300 g, a lip mucous incision of 10 mm length and 4 mm depth was surgically created. Simple random sampling was used to divide the animals into three treatment groups based on wound treatment after lip incision (The control group applied distillation water, the first group applied a lip balm placebo/base, and the second group applied natural lip balm C. burmannii) and then divided into three observation times (days 3rd, 7th, and14th). A lip biopsy was performed during each observation time to determine the success of the therapy. The macroscopic examination was carried out by counting the number of lip wounds that were closed around, while the microscopic examination was carried out by counting epithelialization with a Leica microscope and image raster software. Result: The length of the lip wound has greatly decreased in the C. Burmannii group with a p-value of 0,048 (p<0.05, and epithelialization was comparable across the board. Conclusion: The use of Cinnamomum burmannii natural lip balm is effective in accelerating lip wound healing by bringing the lip wound closer together. Effectiveness of Natural lip balm Cinnamon (Cinnamomum burmannii) in accelerating the incision wound healing process in Rattus norvegicus.Keywords: natural lip balm cinnamomum burmannii; wound closer; epithelialization

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“…These factors are potent inflammatory mediators [ 31 , 32 ]. The anti-inflammatory effect of propolis has been preliminary assessed in the treatment of a variety of inflammatory and ulcerative conditions with low rates of minimal side effects [ 32 , 33 , 34 ]. The use of propolis for the treatment of mouth ulcers is a traditional therapy utilized by some communities in the Middle East.…”

Section: Discussionmentioning

confidence: 99%

Effect of Propolis Paste and Mouthwash Formulation on Healing after Teeth Extraction in Periodontal Disease

Lisbona-González

Muñoz-Soto

Lisbona-González

et al. 2021

Plants

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This study investigated the antimicrobial effects of a mouthwash containing propolis and the effect of a propolis paste formulation on dental healing after teeth extraction in patients with periodontal disease. In the mouthwash experience, the population comprised 40 patients, which were divided as follows: the control mouthwash, 0.2% chlorhexidine (v/v) mouthwash, 2% (w/v) propolis mouthwash, and propolis + chlorhexidine mouthwash. The study of the propolis paste comprised a population of 60 patients with periodontal disease, and a total of 120 symmetric tooth extractions were performed. Propolis showed antimicrobial activity by itself, and especially with the chlorhexidine association. Three days after surgery in the teeth treated with control paste, only 13.4% had completely healed; however, with propolis paste, in 90% of the periodontal sockets, healing was complete. In addition, a reduction in Mutans Streptococci and Lactobacilli cfu was observed with propolis, and especially with the association of chlorhexidine + propolis. Propolis mouthwash reduced bacterial proliferation, especially in association with chlorhexidine. Propolis paste is a viable alternative for socket healing after dental extraction. The knowledge gained from these findings will provide a foundation for similar propolis therapies in order to improve the healing process after dental surgery.

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Effect of local propolis irrigation in experimental periodontitis in rats on inflammatory markers (IL-1β and TNF-α) and oxidative stress

Cited by 8 publications

References 0 publications

Development of propolis and essential oils containing oral/throat spray formulation against SARS-CoV-2 infection

Development of propolis and essential oils containing oral/throat spray formulation against SARS-CoV-2 infection

<strong>Effectiveness of natural lip balm cinnamon <em>(Cinnamomum burmannii)</em> in accelerating the incision wound healing process in <em> rattus norvegicus </em> </strong>

Effect of Propolis Paste and Mouthwash Formulation on Healing after Teeth Extraction in Periodontal Disease

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