Effect of Locally Manufactured Niger Seed Oil on Lipid Profile Compared to Imported Palm and Sunflower Oils on Rat Models

Mekonnen, Zewdie; Gebreselema, Abrha; Abere, Yohannes

doi:10.1155/2018/7846350

Cited by 7 publications

(5 citation statements)

References 40 publications

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“…Mean cardiac total cholesterol and total triglyceride of rats fed with E. pursaetha seed oil were higher than those fed with groundnut oil and normal rat diet. This is in line with the report of Mekonnen et al [24] that the levels of total cholesterol, HDL-c, LDL-c and TAG were significantly (p<0.05) higher in rats fed with 15 % palm oil compared to control groups.…”

Section: Cardiac and Plasma Lipidssupporting

confidence: 93%

PRELIMINARY aTOXICOLOGICAL INVESTIGATION OF ENTADA PURSAETHA SEED OIL

Ajayi¹,

Adejumo²,

Taiwo³

2022

JCSN

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High density lipoprotein (HDL), low density lipoprotein (LDL) and triglyceride (TG) are collectively referred as lipids; their levels could be modified by the type and amount of oil in human diet. In this study, Entada pursaetha seed oil (EPO) was evaluated for its toxicity status in order to determine its suitability/potential for human diet. Oil from E. pursaetha seeds used for this study was extracted with n-hexane. Fifteen wistar rats, distributed into three groups of five rats each, were fed with groundnut oil diet (positive control group), EPO diet (test group) and normal rat diet (control group) for eight weeks after which the animals were sacrificed. During the study period, clinical observation of the rats were noted, body weight of the rats was taken on a weekly basis while haematological analysis of the blood and histopathological evaluation of the heart of the rats were carried out at the end of the study. Clinical observation of the rats revealed that the rats did not show any untoward signs throughout the study period. Body weight increase of the rats was found to be steady and no mortality of any of the rats was recorded for all the groups. There was no significant difference in the haematological analysis result for the blood of the rats in the test and control groups and none of them was anaemic; this is nutritionally significant. The result of the histopathological analysis of the heart of the rats for total cholesterol and triglyceride indicated that rats fed with EPO had higher total cholesterol and triglyceride than the control group rats. EPO seemingly has potential of serving nutritional purposes but must be subjected to refining before this can probably be possible. It can however find very wide application industrially.

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Section: Cardiac and Plasma Lipidssupporting

confidence: 93%

PRELIMINARY aTOXICOLOGICAL INVESTIGATION OF ENTADA PURSAETHA SEED OIL

Ajayi¹,

Adejumo²,

Taiwo³

2022

JCSN

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“…A previous study has demonstrated that grape seed oil and corn oil, that were rich in linoleic acid or omega-6 fatty acids, tended to decrease serum cholesterol levels in rats [70]. Similarly, linoleic acid-rich niger seed oil was found to display a hypolipidemic effect through the facilitation of lipid transportation and metabolism, possibly lowering the risk of cardiovascular disease development [71]. Consistently, a combination diet of proteins, perilla seed oil, linoleic acid and α-linolenic acid (per oral) was found to decrease plasma triglyceride and cholesterol levels in rats [72].…”

Section: Discussionmentioning

confidence: 97%

Phytosterol, Lipid and Phenolic Composition, and Biological Activities of Guava Seed Oil

et al. 2020

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Plant seeds have been found to contain bioactive compounds that have potential nutraceutical benefits. Guava seeds (Psidium guajava) are by-products in the beverage and juice industry; however, they can be utilized for a variety of commercial purposes. This study was designed to analyze the phytochemicals of the n-hexane extract of guava seed oil (GSO), to study its free-radical scavenging activity, and to monitor the changes in serum lipids and fatty acid profiles in rats that were fed GSO. The GSO was analyzed for phytochemicals using chromatographic methods. It was also tested for free-radical scavenging activity in hepatoma and neuroblastoma cells, and analyzed in terms of serum lipids and fatty acids. GSO was found to contain phenolic compounds (e.g., chlorogenic acid and its derivatives) and phytosterols (e.g., stimasterol, β-sitosterol and campesterol), and exerted radical-scavenging activity in cell cultures in a concentration-dependent manner. Long-term consumption of GSO did not increase cholesterol and triglyceride levels in rat serum, but it tended to decrease serum fatty acid levels in a concentration-dependent manner. This is the first study to report on the lipid, phytosterol and phenolic compositions, antioxidant activity, and the hepato- and neuro-protection of hydrogen peroxide-induced oxidative stress levels in the GSO extract.

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“…The mixtures were left to absorb the fried oils at room temperature overnight before the feeding was conducted. 28 , 29 …”

Section: Methodsmentioning

confidence: 99%

Evaluation of the Effect of Hydromethanolic Seed Extract of Lepidium sativum L. (Fetto) on Deep-fried Palm Oil Diet Induced Nonalcoholic Fatty Liver Disease on Male Swiss Albino Mice

Tofik

Zawdie

Nair

et al. 2022

HMER

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Introduction Nonalcoholic fatty liver disease (NAFLD) is the most prevalent disease due to a dramatic change in dietary habits, especially an increase in consumption of fat and carbohydrates in deep-fried foods. Objective The objective was to evaluate the effect of hydromethanolic seed extract of Lepidium sativum on deep-fried palm oil diet induced NAFLDon male mice. Methods An experimental study design was conducted. Twenty-four male mice aged 8 to 10 weeks, weighing 32–42 g were divided into four groups. The four groups were divided into two controls and two treatments. Mice in normal control (C 0 ) were administered only with the basal diet whereas negative control (C 1 ) provided only with the deep-fried palm oil diet. The treatment groups T 1, and T 2 were administered with deep-fried palm oil diet and HMSELS at dose of 200 and 400 mg/kg/day, respectively for 28 days. Then on day 29, the mice were fasted overnight, anaesthetized and sacrificed by cervical dislocation after blood was taken by cardiac puncture for liver function tests while liver tissues were taken for histopathology investigation. Results The serum ALT and total bilirubin showed significant decrement whereas the serum albumin levels showed significant increment in T 2 group. However, serum AST and ALP levels were decreased significantly in both T 1 and T 2 groups. Besides, the T 2 group liver sections of mice were showed better effect of HMSELS on restoring the damaged liver histopathology almost toward normal. Conclusion The HMSELS at a dose of 400 mg/kg/day (T 2 ) was more effective on the liver function tests and liver histopathology that altered by feeding deep-fried palm oil diet. The good protective effect of HMSELS against deep-fried palm oil diet-induced NAFLD might be due to its antioxidant content.

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Effect of Locally Manufactured Niger Seed Oil on Lipid Profile Compared to Imported Palm and Sunflower Oils on Rat Models

Cited by 7 publications

References 40 publications

PRELIMINARY aTOXICOLOGICAL INVESTIGATION OF ENTADA PURSAETHA SEED OIL

PRELIMINARY aTOXICOLOGICAL INVESTIGATION OF ENTADA PURSAETHA SEED OIL

Phytosterol, Lipid and Phenolic Composition, and Biological Activities of Guava Seed Oil

Evaluation of the Effect of Hydromethanolic Seed Extract of Lepidium sativum L. (Fetto) on Deep-fried Palm Oil Diet Induced Nonalcoholic Fatty Liver Disease on Male Swiss Albino Mice

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