Effect of long term fluoride exposure on lipid composition in rat liver

Wang, Yanan; Xiao, Kai-Qi; Liu, Jialiu; Dallner, Gustav; Guan, Zhi‐Zhong

doi:10.1016/s0300-483x(00)00167-0

Cited by 75 publications

(35 citation statements)

References 15 publications

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“…The administration of high doses of NaF also caused increase in plasma lipids. It is consistent with previous reports, indicating that the fluorosis may cause disturbances in lipid metabolism (Chinoy et al 1994;Wang et al 2000). The combined administration of tamoxifen with fluoride reduced the changes in serum lipids, increased bone mineral density and bone mineral content, but did not influence bone strength and stiffness.…”

Section: Discussionsupporting

confidence: 93%

“…The use of relatively higher doses of fluoride in man unfortunately resulted in the increase of fractures as well as other sideeffects (Boivin et al 1993). Animal studies have shown that therapy with high doses of fluoride induces disturbances in lipid metabolism (Chinoy et al 1994;Wang et al 2000). Riggs et al (1990) hypothesized that the combination of fluoride with oestrogens may reduce the side effects of fluoride.…”

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confidence: 99%

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The Effect of Tamoxifen and Fluoride on Bone Mineral Density, Biomechanical Properties and Blood Lipids in Ovariectomized Rats

Czerny¹,

Pawlik²,

Juzyszyn³

et al. 2004

Basic Clin Pharma Tox

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Abstract:The most important aspect of therapy with fluoride and tamoxifen concerns its influence on bone tissue and lipid metabolism. The aim of the study was to evaluate the effect of tamoxifen and natrium fluoride (NaF) on bone metabolism, biochemical properties and blood lipids levels in ovariectomized rats. The study was performed in Wistar rats divided into 5 subgroups: ovariectomized controls, rats treated with NaF 20 mg/kg/24 hr, rats treated with NaF 20 mg/kg/24 hrπtamoxifen 2 mg/kg/24 hr, rats treated with NaF 20 mg/kg/24 hr plus tamoxifen 4 mg/kg/24 hr, and shamoperated controls. In ovariectomized rats the increase of total cholesterol, low-density lipoproteins cholesterol (LDLcholesterol) as well as the decrease of bone mineral content, bone mineral density and biomechanical properties was observed. The therapy with NaF increased the level of total cholesterol, LDL-cholesterol, triglycerides, bone mineral density, bone mineral content. In this group the decrease of bone strength and stiffness was observed. The administration of tamoxifen reduced the changes in plasma lipid levels, but did not improve the biomechanical properties of bone tissue.Natrium fluoride (NaF) is used experimentally and in clinical trials for treatment of osteoporosis. However several studies have shown structural abnormalities or mineralization defect in the bone formed during fluoride administration (Kleerekoper et al. 1991).In contrast to oestrogen suppression of bone turn-over, fluoride stimulates bone formation. The controversy revolves around the issue of whether this new bone is biomechanical sound enough to reduce fractural risk. The use of relatively higher doses of fluoride in man unfortunately resulted in the increase of fractures as well as other sideeffects (Boivin et al. 1993). Animal studies have shown that therapy with high doses of fluoride induces disturbances in lipid metabolism (Chinoy et al. 1994;Wang et al. 2000). Riggs et al. (1990) hypothesized that the combination of fluoride with oestrogens may reduce the side effects of fluoride. The aim of present study was to evaluate whether the administration of tamoxifen reduce the changes in lipid metabolism induced by high doses of NaF as well as the possibility of a positive effect on bone mass and biomechanical properties. Materials and MethodsFemale Wistar rats were used in this experiment. They were allowed to acclimatize for a minimum of 10 days prior to the study. The Author for correspondence: Andrzej Pawlik, Department of Pharmacokinetics and Therapeutic Drug Monitoring Pomeranian Medical University, Powstań ców Wielkopolskich 72, PL 70-111 Szczecin, Poland (fax π48 91 4661600, e-mail pawand/poczta. onet.pl).rats were housed in a room maintained of 21∫1 ae with 12 hr light:-dark cycle with the light cycle on at 6:00 a.m. At 3 months of age 50 female rats (body weight 238.3∫10.4 g) were anaesthetized with a combination of ketamin (Ketalar, Warner-Lamert, Schweiz) and xylazin (Rompun, Bayer, Germany) and were ovariectomized (40 individuals) or sham-operate...

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

The Effect of Tamoxifen and Fluoride on Bone Mineral Density, Biomechanical Properties and Blood Lipids in Ovariectomized Rats

Czerny¹,

Pawlik²,

Juzyszyn³

et al. 2004

Basic Clin Pharma Tox

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“…Studies showed that chronic fluorosis also cause toxicity on renal, muscle, thyriod, GIS and alter erythrocyte membrane (1). Especially toxic effects of fluorine in soft tissues because of free radicals and mitochondrial damage due to oxidative stress (19,20). Sialic acids, which is found in surface of several cells and its responsible for antigenic characteristic, should be an important component of glycolipids and glycoproteins (21).…”

Section: Discussionmentioning

confidence: 99%

The Protective Role Of Resveratrol On Serum Total Sialic Acid And Lipid-Bound Sialic Acid In Female Rats With Chronic Fluorosis

Oto¹,

Ekin²,

Özdemir³

et al. 2016

Eastern J Med

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“…There is a narrow margin between the desired and harmful doses of fluoride [2]. Low concentration of fluoride in drinking water have been considered beneficial to prevent dental carries [3], but excessive exposure to fluoride can give rise to a number of adverse effects such as causing fluorosis [1,4,5]. WHO has set a limit value of 1.5 mg·L −1 for fluoride in drinking water [6].…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of Fluoride in Groundwater Using Resorcin Blue Complexes

Barghouthi¹,

Amereih²

2012

AJAC

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Effect of long term fluoride exposure on lipid composition in rat liver

Cited by 75 publications

References 15 publications

The Effect of Tamoxifen and Fluoride on Bone Mineral Density, Biomechanical Properties and Blood Lipids in Ovariectomized Rats

The Effect of Tamoxifen and Fluoride on Bone Mineral Density, Biomechanical Properties and Blood Lipids in Ovariectomized Rats

The Protective Role Of Resveratrol On Serum Total Sialic Acid And Lipid-Bound Sialic Acid In Female Rats With Chronic Fluorosis

Spectrophotometric Determination of Fluoride in Groundwater Using Resorcin Blue Complexes

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