Effect of long-term trimethoprim/sulfamethoxazole treatment on resistance and integron prevalence in the intestinal flora: a randomized, double-blind, placebo-controlled trial in children

Veen, Erwin L. van der; Schilder, Anne G. M.; Timmers, Tim K.; Rovers, Maroeska M.; Fluit, Ad C.; Bonten, Marc J. M.; Hall, Maurine A. Leverstein–van

doi:10.1093/jac/dkp050

Cited by 28 publications

(27 citation statements)

References 24 publications

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“…Bands 5 and 12 revealed slight changes in healthy fish gut after the antibiotic treatment, both bands showing high similarities to Enterobacteriaceae. Van der Veen et al (2009) found that trimethoprim/sulfamethoxazole was closely associated with the appearance of (multi)drugresistant Enterobacteriaceae in child intestinal flora. Enterobacteriaceae might be the major drug-resistant bacteria in gibel carp intestine.…”

Section: Discussionmentioning

confidence: 99%

Gibel carp Carassius auratus gut microbiota after oral administration of trimethoprim/ sulfamethoxazole

Liu¹,

Zhou²,

Wu³

et al. 2012

Dis. Aquat. Org.

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Trimethoprim/sulfamethoxazole is widely used in the treatment of infectious diseases caused by bacterial pathogens in aquaculture. However, the practice of antibiotic administration can promote the emergence of resistant strains of bacteria and result in a wane in efficacy over time. The objective of this study was to assess the effect of oral treatment with trimethoprim/ sulfamethoxazole on the gastrointestinal (GI) microbiota of healthy gibel carp and those affected with bacterial enteritis. By using denaturing gradient gel electrophoresis (DGGE), the changes in the predominant bacterial communities were directly depicted for the first time. The main findings were (1) Actinobacteria, Firmicutes and Proteobacteria were the predominant phyla in the healthy gibel carp intestine; (2) administration of antibiotics had a more profound impact on the intestinal microflora of healthy fish than of the diseased ones; and (3) Enterobacteriaceae might be one of the major drug-resistant bacteria in the gibel carp intestine. This study provides an insight into the effect of antibiotic treatment on the establishment and colonization of fish GI microbiota and specu lates on some possible drug-resistant bacteria.KEY WORDS: Gastrointestinal microbiota · Gibel carp · Trimethoprim/sulfamethoxazole · PCR−DGGE Resale or republication not permitted without written consent of the publisher

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Section: Discussionmentioning

confidence: 99%

Gibel carp Carassius auratus gut microbiota after oral administration of trimethoprim/ sulfamethoxazole

Liu¹,

Zhou²,

Wu³

et al. 2012

Dis. Aquat. Org.

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“…78 Clearly, the host environment as well as the antibiotic treatment are likely to be influencing integron transfer on MGEs, a similar situation as seen with ICEs. 60 An interesting observation by van der Veen et al 102 was that the prevalence of integrons within the intestinal microbial populations decreased despite continued antibiotic treatment. This may indicate that there is a cost to the bacteria of carrying either the integron or its shuttle element.…”

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confidence: 99%

“…3B). Hochut et al 107 found that an SXT conjugative element is embedded within rumB in V. cholera and suggested that a transposon had inserted into the DNA and intestines of humans and chickens showed that there may be a correlation in acquisition based on treatment with antibiotics 102 although another study suggested this is not the case. 78 Clearly, the host environment as well as the antibiotic treatment are likely to be influencing integron transfer on MGEs, a similar situation as seen with ICEs.…”

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confidence: 99%

The influence of the accessory genome on bacterial pathogen evolution

Jackson

Vinatzer

Arnold

et al. 2011

Mobile Genetic Elements

116

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“…Children receiving TMP/SMX were found to have higher rates of multidrug-resistant Enterobacteriaceae in their intestinal flora compared to placebotreated children, possibly through selection of an integron carrying multiple resistance genes (33). However, a recent systematic review did not find a relationship between TMP/SMX prophylaxis and other resistant microbial flora in patients with HIV infection (29).…”

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confidence: 99%

Has the Emergence of Community-Associated Methicillin-Resistant Staphylococcus aureus Increased Trimethoprim-Sulfamethoxazole Use and Resistance?: a 10-Year Time Series Analysis

Wood¹,

Smith²,

Baker

et al. 2012

Antimicrob Agents Chemother

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There are an increasing number of indications for trimethoprim-sulfamethoxazole use, including skin and soft tissue infections due to community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). Assessing the relationship between rates of use and antibiotic resistance is important for maintaining the expected efficacy of this drug for guideline-recommended conditions. Using interrupted time series analysis, we aimed to determine whether the 2005 emergence of CA-MRSA and recommendations of trimethoprim-sulfamethoxazole as the preferred therapy were associated with changes in trimethoprim-sulfamethoxazole use and susceptibility rates. The data from all VA Boston Health Care System facilities, including 118,863 inpatient admissions, 6,272,661 outpatient clinic visits, and 10,138 isolates were collected over a 10-year period. There was a significant (P ‫؍‬ 0.02) increase in trimethoprim-sulfamethoxazole prescriptions in the post-CA-MRSA period (1,605/year) compared to the pre-CA-MRSA period (1,538/year). Although the overall susceptibility of Escherichia coli and Proteus spp. to trimethoprim-sulfamethoxazole decreased over the study period, the rate of change in the pre-versus the post-CA-MRSA period was not significantly different. The changes in susceptibility rates of S. aureus to trimethoprim-sulfamethoxazole and to methicillin were also not significantly different. The CA-MRSA period is associated with a significant increase in use of trimethoprim-sulfamethoxazole but not with significant changes in the rates of susceptibilities among clinical isolates. There is also no evidence for selection of organisms with increased resistance to other antimicrobials in relation to increased trimethoprim-sulfamethoxazole use.

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Effect of long-term trimethoprim/sulfamethoxazole treatment on resistance and integron prevalence in the intestinal flora: a randomized, double-blind, placebo-controlled trial in children

Cited by 28 publications

References 24 publications

Gibel carp Carassius auratus gut microbiota after oral administration of trimethoprim/ sulfamethoxazole

Gibel carp Carassius auratus gut microbiota after oral administration of trimethoprim/ sulfamethoxazole

The influence of the accessory genome on bacterial pathogen evolution

Has the Emergence of Community-Associated Methicillin-Resistant Staphylococcus aureus Increased Trimethoprim-Sulfamethoxazole Use and Resistance?: a 10-Year Time Series Analysis

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