Effect of low density lipoproteins on secretion of plasminogen activator inhibitor-1 (PAI-1) by human endothelial cells and hepatoma cells

Latron, Y; Alessi, Marie‐Christine; Anfosso, Francine; Nalbonne, G.; Lafont, Huguette; Portugal, Henri; Juhan‐Vague, I.

doi:10.1016/0268-9499(90)90368-t

Cited by 19 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another argument for the role of circulating lipid levels in regulating PAI-1 concentration is that we have shown strong stimulation of the hepatocyte synthesis of PAI-1 by normal non-oxidized LDL [83], this effect being dependent of the binding of LDL to the apolipoprotein B/E receptors.…”

Section: Attemps At Explaining the Increased Plasma Pai-1 Levels In Imentioning

confidence: 90%

Increased plasma plasminogen activator inhibitor 1 levels. A possible link between insulin resistance and atherothrombosis

1991

Self Cite

View full text Add to dashboard Cite

According to recent prospective studies, hypofibrinolysis due to elevated plasma plasminogen activator inhibitor 1 levels appears to be an independent risk factor for myocardial reinfarction in men, and hyperinsulinaemia, a major indicator of insulin resistance is considered as a risk factor for coronary disease. It has recently been shown that insulin resistance is accompanied by an increased plasma plasminogen activator inhibitor 1 concentration: A significant correlation coefficient was demonstrated between plasminogen activator inhibitor 1 and fasting plasma insulin in the normal population, in obese subjects, in Type 2 (non-insulin-dependent) diabetic patients and in angina pectoris. Attempts to decrease insulin resistance such as fasting, diet, or administration of an oral anti-diabetic drug such as Metformin induced a parallel decrease in plasma insulin and plasminogen activator inhibitor 1 levels. This inhibitor is produced by endothelial cells and by hepatocytes in culture. Plasminogen activator inhibitor 1 synthesis by hepatocytes in culture was stimulated by an increasing insulin concentration, or low density lipoproteins, whereas the endothelial cell synthesis was stimulated by very low density lipoproteins especially when they were obtained from hypertriglyceridaemic patients. Therefore, a direct effect of insulin or lipoprotein changes on the cells which synthesize plasminogen activator inhibitor 1 could be responsible for its increased plasma concentration in insulin resistance states. The increase in plasma plasminogen activator inhibitor 1 levels linked to hyperinsulinaemia is a tempting partial explanation for the association between insulin resistance and coronary disease.

show abstract

Section: Attemps At Explaining the Increased Plasma Pai-1 Levels In Imentioning

confidence: 90%

Increased plasma plasminogen activator inhibitor 1 levels. A possible link between insulin resistance and atherothrombosis

1991

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, as no correlation has been found in vivo between plasma Lp(a) levels and plasma PAI-1 levels (51), the stimulating effect of Lp(a) on endothelial PAI-1 synthesis may act locally without inducing a systemic change in PAI-1 levels. PAI-1 synthesis has also been stimulated by VLDL (105) and nonoxidized LDL in Hep G2 cells (109).…”

Section: Systemic Increased Pai-1 Concentration and Atherothrombosismentioning

confidence: 96%

Plasminogen Activator Inhibitor 1 and Atherothrombosis

1993

View full text Add to dashboard Cite

“…This finding contrasts with the triggering effect of N-LDL on PAI-1 synthesis by the hepatoma cell line Hep G2. 27 The discrepancy between ox-LDL and N-LDL does not result from a defect in binding to the cell surface receptor. HUVEC, as well as other cells such as HepG2, possess high-affinity receptors for LDL.…”

Section: Figure 2 Plots Of Effect Of Oxidized Low Density Lipoproteimentioning

confidence: 99%

“…26 In a previous study, we showed that while N-LDL did not modify PAI-1 synthesis by HUVEC, they did increase PAI-1 synthesis by a HepG2 hepatoma cell line. 27 The purpose of the present study was to investigate the effect of ox-LDL on PAI-1 synthesis by endothelial cells.…”

mentioning

confidence: 99%

Stimulating effect of oxidized low density lipoproteins on plasminogen activator inhibitor-1 synthesis by endothelial cells.

Latron

Chautan

Anfosso

et al. 1991

Arterioscler Thromb

101

View full text Add to dashboard Cite

Effect of low density lipoproteins on secretion of plasminogen activator inhibitor-1 (PAI-1) by human endothelial cells and hepatoma cells

Cited by 19 publications

References 11 publications

Increased plasma plasminogen activator inhibitor 1 levels. A possible link between insulin resistance and atherothrombosis

Increased plasma plasminogen activator inhibitor 1 levels. A possible link between insulin resistance and atherothrombosis

Plasminogen Activator Inhibitor 1 and Atherothrombosis

Stimulating effect of oxidized low density lipoproteins on plasminogen activator inhibitor-1 synthesis by endothelial cells.

Contact Info

Product

Resources

About