1984
DOI: 10.1016/s0022-3476(84)80035-9
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Effect of low-dose dopamine therapy on catecholamine values in cerebrospinal fluid in preterm neonates

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Cited by 24 publications
(27 citation statements)
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“…The synthesis and secretion of the anterior pituitary hormones are in fact under the control of neuropeptides, which are released from the hypothalamus into a capillary portal plexus fl owing through the external zone of the median eminence to the anterior lobe of the pituitary gland. Many studies have demonstrated that dopamine infusion inhibits the release of pituitary hormones in adults, children, and infants [2,3] , even if it is able to cross the blood-brain barrier only in preterm infants [4] . Functional dopamine receptors (D 2 -like receptors) controlling hormonal secretion on the hypothalamic-pituitary axis are in fact located in the anterior and intermediate lobes and in the hypothalamic median eminence, both placed outside of the blood-brain barrier [5] .…”
Section: Dopamine Infusion In Vlbw Infantsmentioning
confidence: 99%
“…The synthesis and secretion of the anterior pituitary hormones are in fact under the control of neuropeptides, which are released from the hypothalamus into a capillary portal plexus fl owing through the external zone of the median eminence to the anterior lobe of the pituitary gland. Many studies have demonstrated that dopamine infusion inhibits the release of pituitary hormones in adults, children, and infants [2,3] , even if it is able to cross the blood-brain barrier only in preterm infants [4] . Functional dopamine receptors (D 2 -like receptors) controlling hormonal secretion on the hypothalamic-pituitary axis are in fact located in the anterior and intermediate lobes and in the hypothalamic median eminence, both placed outside of the blood-brain barrier [5] .…”
Section: Dopamine Infusion In Vlbw Infantsmentioning
confidence: 99%
“…However, some data should be considered: dopamine can penetrate the central nervous system both in the developing rat [41] and sick preterm infant [42] through an incompletely developed blood-brain barrier; the pharmacokinetic study of dopamine in critically ill newborn infants indicates that an infusion rate of 4-8 mg/kg/min induces a plasma concentration of 0.5-70 ng/mL [43]; the 10 and 100 mM dopamine concentrations in the medium of our cultures correspond to 1890 and 18 900 ng/mL, respectively; it is unlikely that these values can be reached following the reported in vivo dopamine plasma concentrations. Thus, it may be indirectly concluded that dopamine treatment can increase its local concentration in the brain, but without reaching neurotoxic levels.…”
mentioning
confidence: 99%
“…Unfortunately, this possibility has not been substantiated by AVP determina tions. Nevertheless, it should be seriously considered because in sick prematue infants DA has been demonstrated to cross bloodbrain barrier and to induce marked changes in cerebral monoamine metabolism [15], thereby it may alter AVP release, not only di rectly by binding to pituitary receptors, but also indirectly at the hypothalamic level.…”
Section: Discussionmentioning
confidence: 99%