Effect of Low-Dose Heparin on Incidence of Postoperative Pulmonary Embolism Detected by Photoscanning

Lahnborg, G; Bergström, Kurt; Friman, Leif; Lagergren, H

doi:10.1016/s0140-6736(74)93076-1

Cited by 87 publications

(21 citation statements)

References 16 publications

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“…The electronic searches and the hand-search revealed 558 studies. Of these 19 fullfilled the criteria for inclusion for analysis [10,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. In 66 occasions primary authors and ⁄ or sponsoring pharmaceutical companies were contacted in order to obtain the colorectal data.…”

Section: Description Of Studiesmentioning

confidence: 99%

“…The bleeding episodes for colorectal patients only could only be defined in two studies [15,16]. Eleven studies [14,15,[18][19][20][21][22][23][24][25][26] tested any kind of heparin vs no treatment or placebo in a total of 641 patients. Four studies [13,16,27,28] tested unfractionated heparin vs LMWH in a total of 1183 patients and four studies [10,17,29,30] investigated mechanical methods in various combinations or alone in a total of 130 patients.…”

Section: Description Of Studiesmentioning

confidence: 99%

“…In 15 studies [10,13,14,[17][18][19][20][22][23][24][25][27][28][29][30] the 125 I-fibrinogen uptake test was the primary screening method for DVT, supplied with confirmatory venography in 5 studies [10,14,17,22,27]. Mandatory venography was used in one (the largest) study [16] while Doppler-ultrasound was used in three studies.…”

Section: Description Of Studiesmentioning

confidence: 99%

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Systematic review of thromboprophylaxis in colorectal surgery – an update

2005

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Section: Description Of Studiesmentioning

confidence: 99%

Section: Description Of Studiesmentioning

confidence: 99%

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Systematic review of thromboprophylaxis in colorectal surgery – an update

2005

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“…The overall frequency is of a magnitude to be expected in patients undergoing abdominal surgery with low-dose heparin prophylaxis, and decidedly lower than in patients given no pharmacologic prophylaxis at all [13][14][15][16], One interesting finding was the delay in the appearance of thrombosis in the group given the LMW fragment. The reason is not easily explained, as the anti-Xa activity is much higher in the fragment group.…”

Section: Discussionmentioning

confidence: 99%

Prospective Double-Blind Comparison between Fragmin and Conventional Low-Dose Heparin: Thromboprophylactic Effect and Bleeding Complications

Bergqvist

Burmark

Frisell

et al. 1986

Pathophysiol Haemos Thromb

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In a randomized, prospective, double-blind multicenter trial, the effect of low-dose conventional heparin (5,000 IU/12 h) was compared to a low molecular weight (LMW) heparin fragment (5,000 antifactor Xa U/24 h). 432 patients 40 years or older undergoing elective abdominal surgery were included, 382 correctly treated. 45% had malignant diseases. The groups did not differ in risk factors. Analysis was made both on the basis of intention to treat and correct prophylaxis. No difference in results between these 2 groups was seen. Deep vein thrombosis (¹²⁵I-fibrinogen) occurred in 4.3% of the low-dose heparin group and in 6.4 of the LMW heparin group. There was a significant delay in the onset of deep vein thrombosis in the LMW heparin group. Mortality, peroperative blood loss, transfusions or infectious complications did not differ. Hemorrhagic complications occurred significantly more often in the LMW heparin group (11.6%) than in the low-dose heparin group (4.6%). Significantly fewer patients experienced local injection pain in the LMW heparin group. APTT and AT III were similar in both groups, but anti-Xa activity was significantly higher in the LMW heparin group. Single daily LMW heparin injection reduced the frequency of deep vein thrombosis to the same level as low-dose heparin twice daily. The dose or administration interval of LMW heparin in this study caused significantly more bleeding complications.

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“…Van Vroonhoven, van Zijl and Muller (1974) have demonstrated the superiority of low-dose subcutaneous heparin over oral anticoagulants in this respect. Naturally, the vital factor is whether this therapy actually reduces the incidence of post-operative pulmonary embolism; this is certainly suggested by the trial reported by Lahnborg et al (1974). These authors report a double-blind trial on fifty-four control patients and fifty-eight treated cases undergoing major surgery who were followed-up with chest photoscans and chest X-rays, together with fibrinogen scanning of the legs.…”

Section: Prophylaxismentioning

confidence: 99%

Review of general surgery 1974

Ellis

1975

Postgraduate Medical Journal

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Introduction In this year’s review, the author, once again, has selected those subjects which he has found of personal interest and appeal during the year. Cholecystectomy is one of the commonest major general surgical operations and, therefore, its post-operative complications are extremely important in the hospital community. Acute pancreatitis continues to be a somewhat mysterious condition which remains a clinical, diagnostic, and therapeutic challenge. There is evidence that renal calculi are being seen with ever increasing frequency in the Western World and there is naturally considerable interest in their diagnosis and management. New methods of investigation continue to make the study of deep vein thrombosis and pulmonary embolism an important and exciting topic. Realizing his surgical limitations, the surgeon is anxious to learn about new concepts of prophylaxis, early diagnosis and treatment in malignant disease; a number of interesting papers are discussed in this area. Surgeons are paying increasing attention to the local and systemic factors which are of importance in the healing of their gastro-intestinal anastomoses and much work of interest has been reported in this field. We report new studies in the management of patients with extensive burns and we conclude with one or two eye-catching papers which have been published during the year.

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Effect of Low-Dose Heparin on Incidence of Postoperative Pulmonary Embolism Detected by Photoscanning

Cited by 87 publications

References 16 publications

Systematic review of thromboprophylaxis in colorectal surgery – an update

Systematic review of thromboprophylaxis in colorectal surgery – an update

Prospective Double-Blind Comparison between Fragmin and Conventional Low-Dose Heparin: Thromboprophylactic Effect and Bleeding Complications

Review of general surgery 1974

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