Effect of low dose of berberine on the radioresistance of cervical cancer cells via a PI3K/HIF-1 pathway under nutrient-deprived conditions

Zeng, Xiaozhu; Wan, Linghong; Wang, Yu; Xue, Jinmin; Yang, Huili; Yu-xi, Zhu

doi:10.1080/09553002.2020.1770358

Cited by 11 publications

(13 citation statements)

References 23 publications

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“…For example, the combination of berberine and matrine synergistically inhibited cervical cancer cell proliferation, triggered cell apoptosis, and induced cell cycle arrest at G1 phase [ 107 ]. Berberine could also overcome the radio-resistance caused by low-glucose and hypoxia in the radiotherapy of cervical cancer via regulating the glucose metabolism through PI3K/HIF-1 pathway [ 108 ].…”

Section: Effects Of Berberine On Cancersmentioning

confidence: 99%

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Xiong

Huang

et al. 2022

Molecules

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Cancer has been a serious public health problem. Berberine is a famous natural compound from medicinal herbs and shows many bioactivities, such as antioxidant, anti-inflammatory, antidiabetic, anti-obesity, and antimicrobial activities. In addition, berberine shows anticancer effects on a variety of cancers, such as breast, lung, gastric, liver, colorectal, ovarian, cervical, and prostate cancers. The underlying mechanisms of action include inhibiting cancer cell proliferation, suppressing metastasis, inducing apoptosis, activating autophagy, regulating gut microbiota, and improving the effects of anticancer drugs. This paper summarizes effectiveness and mechanisms of berberine on different cancers and highlights the mechanisms of action. In addition, the nanotechnologies to improve bioavailability of berberine are included. Moreover, the side effects of berberine are also discussed. This paper is helpful for the prevention and treatment of cancers using berberine.

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Section: Effects Of Berberine On Cancersmentioning

confidence: 99%

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Xiong

Huang

et al. 2022

Molecules

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“…Hence, Zeng and colleagues investigated the radiosensitizing potential of BBR in HeLa human cervical carcinoma cells under oxygen and glucose-deprived conditions. Interestingly, BBR overcomes both low glucose and hypoxia-induced radioresistance by down-regulating PI3K/HIF-1 pathway (Zeng et al, 2020). Pan and colleagues extensively studied the chemosensitizing effects of BBR in hypoxic breast tumors to doxorubicin therapy.…”

Section: Bbr Overcomes Therapy Resistance In Hypoxic Tumorsmentioning

confidence: 99%

Berberine—A potent chemosensitizer and chemoprotector to conventional cancer therapies

Devarajan

Jayaraman

Mahendra

et al. 2021

Phytotherapy Research

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Chemotherapy and radiotherapy are mainstay treatments for cancer patients. However, their clinical outcomes are highly limited by the resistance of malignant tumors to these therapies and the incurrence of serious damages in vital organs. This in turn necessitates the development of adjunct drugs that overcomes chemo/radioresistance in refractory cancers and protects vital organs from the cytotoxic effects of cancer therapies. In recent years, Berberine (BBR), a natural isoquinoline alkaloid has garnered more attention due to its potent chemosensitizing and chemoprotective properties. BBR effectively sensitizes refractory cancers to chemotherapy and radiotherapy by ameliorating the diverse events underlying therapy resistance. Furthermore, it protects the heart, liver, lungs, and kidneys from severe damages caused by these therapies. In this review, we discuss the molecular mechanisms underlying the chemo/radiosensitizing and chemo/radioprotective potential of BBR during cancer treatment. Also, we highlight the limitations that hamper the clinical application of BBR as an adjunct drug and how novel innovations have been made in recent years to circumvent these challenges.

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“…RT is the main treatment choice for LACC ( 11 , 12 ). It directly causes tumor cell DNA double-strand breaks (DSBs), and the reactive oxygen species (ROS) induced by RT also indirectly causes DNA damage.…”

Section: Introductionmentioning

confidence: 99%

Recent progress of the tumor microenvironmental metabolism in cervical cancer radioresistance

et al. 2022

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Radiotherapy is widely used as an indispensable treatment option for cervical cancer patients. However, radioresistance always occurs and has become a big obstacle to treatment efficacy. The reason for radioresistance is mainly attributed to the high repair ability of tumor cells that overcome the DNA damage caused by radiotherapy, and the increased self-healing ability of cancer stem cells (CSCs). Accumulating findings have demonstrated that the tumor microenvironment (TME) is closely related to cervical cancer radioresistance in many aspects, especially in the metabolic processes. In this review, we discuss radiotherapy in cervical cancer radioresistance, and focus on recent research progress of the TME metabolism that affects radioresistance in cervical cancer. Understanding the mechanism of metabolism in cervical cancer radioresistance may help identify useful therapeutic targets for developing novel therapy, overcome radioresistance and improve the efficacy of radiotherapy in clinics and quality of life of patients.

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Effect of low dose of berberine on the radioresistance of cervical cancer cells via a PI3K/HIF-1 pathway under nutrient-deprived conditions

Cited by 11 publications

References 23 publications

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Anticancer Effects and Mechanisms of Berberine from Medicinal Herbs: An Update Review

Berberine—A potent chemosensitizer and chemoprotector to conventional cancer therapies

Recent progress of the tumor microenvironmental metabolism in cervical cancer radioresistance

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