Effect of low estrogen on neurons in the preoptic area of hypothalamus of ovariectomized rats

Wang, Wenjuan; Wang, Zhiyuan; Bai, Wenpei; Zhang, Hui; Ma, Xiaochen; Yang, Mukun; Wang, Ke; Zhu, Shijun; Jia, Junjing; Qin, Lihua

doi:10.1016/j.acthis.2014.07.010

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…These findings suggest that periodic release of sex steroids could further reinforce ultradian temperature patterns. As might be expected, in ovariectomized animals, the pattern of temperature ( Kobayashi et al, 2000 ; Opas et al, 2004 ) and the activity of temperature-sensitive cells in the POA is both reduced and disordered ( Wang et al, 2014 ). Conversely, their pattern of activity can be rescued, in part, by phytoestrogen-rich food (e.g., black cohosh) and by direct estradiol replacement ( Opas et al, 2004 ; Hui et al, 2012 ).…”

Section: Introductionsupporting

confidence: 56%

Neural substrates underlying rhythmic coupling of female reproductive and thermoregulatory circuits

Grant,

Kriegsfeld

2023

Front. Physiol.

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Coordinated fluctuations in female reproductive physiology and thermoregulatory output have been reported for over a century. These changes occur rhythmically at the hourly (ultradian), daily (circadian), and multi-day (ovulatory) timescales, are critical for reproductive function, and have led to the use of temperature patterns as a proxy for female reproductive state. The mechanisms underlying coupling between reproductive and thermoregulatory systems are not fully established, hindering the expansion of inferences that body temperature can provide about female reproductive status. At present, numerous digital tools rely on temperature to infer the timing of ovulation and additional applications (e.g., monitoring ovulatory irregularities and progression of puberty, pregnancy, and menopause are developed based on the assumption that reproductive-thermoregulatory coupling occurs across timescales and life stages. However, without clear understanding of the mechanisms and degree of coupling among the neural substrates regulating temperature and the reproductive axis, whether such approaches will bear fruit in particular domains is uncertain. In this overview, we present evidence supporting broad coupling among the central circuits governing reproduction, thermoregulation, and broader systemic physiology, focusing on timing at ultradian frequencies. Future work characterizing the dynamics of reproductive-thermoregulatory coupling across the lifespan, and of conditions that may decouple these circuits (e.g., circadian disruption, metabolic disease) and compromise female reproductive health, will aid in the development of strategies for early detection of reproductive irregularities and monitoring the efficacy of fertility treatments.

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Section: Introductionsupporting

confidence: 56%

Neural substrates underlying rhythmic coupling of female reproductive and thermoregulatory circuits

Grant,

Kriegsfeld

2023

Front. Physiol.

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“…MPOA subregions show either cold-sensing or warm-sensing properties in sham female rats. However, after estrogen depletion by OVX, c-fos signaling is significantly decreased, and thermosensitivity of MPOA subregions is impaired ( 135 ). The MPOA has also been linked with torpor regulation in rodents.…”

Section: Estrogen In the Brainmentioning

confidence: 99%

Hypothalamic Estrogen Signaling and Adipose Tissue Metabolism in Energy Homeostasis

Irizarry

Jiang

et al. 2022

Front. Endocrinol.

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Obesity has become a global epidemic, and it is a major risk factor for other metabolic disorders such as type 2 diabetes and cardiometabolic disease. Accumulating evidence indicates that there is sex-specific metabolic protection and disease susceptibility. For instance, in both clinical and experimental studies, males are more likely to develop obesity, insulin resistance, and diabetes. In line with this, males tend to have more visceral white adipose tissue (WAT) and less brown adipose tissue (BAT) thermogenic activity, both leading to an increased incidence of metabolic disorders. This female-specific fat distribution is partially mediated by sex hormone estrogens. Specifically, hypothalamic estrogen signaling plays a vital role in regulating WAT distribution, WAT beiging, and BAT thermogenesis. These regulatory effects on adipose tissue metabolism are primarily mediated by the activation of estrogen receptor alpha (ERα) in neurons, which interacts with hormones and adipokines such as leptin, ghrelin, and insulin. This review discusses the contribution of adipose tissue dysfunction to obesity and the role of hypothalamic estrogen signaling in preventing metabolic diseases with a particular focus on the VMH, the central regulator of energy expenditure and glucose homeostasis.

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The neuroendocrinology of the preoptic area in menopause: Symptoms and therapeutic strategies

Modi

Dhillo

2021

Handbook of Clinical Neurology

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Effect of low estrogen on neurons in the preoptic area of hypothalamus of ovariectomized rats

Cited by 7 publications

References 17 publications

Neural substrates underlying rhythmic coupling of female reproductive and thermoregulatory circuits

Neural substrates underlying rhythmic coupling of female reproductive and thermoregulatory circuits

Hypothalamic Estrogen Signaling and Adipose Tissue Metabolism in Energy Homeostasis

The neuroendocrinology of the preoptic area in menopause: Symptoms and therapeutic strategies

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