Effect of Low-Intensity Pulsed Ultrasound on Orthodontically Induced Root Resorption in Beagle Dogs

Al-Daghreer, Saleh; Doschak, Michael R.; Sloan, Alastair James; Major, Paul W.; Heo, Giseon; Scurtescu, Cristian; Tsui, Ying Y.; El‐Bialy, Tarek

doi:10.1016/j.ultrasmedbio.2013.12.016

Cited by 46 publications

(39 citation statements)

References 26 publications

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“…In the other hand, osteoblasts seem to respond differently from cementoblasts after LIPUS application, as previously reported (ElBialy et al, 2011;Xue et al, 2013;Al-Daghreer et al, 2014). In the in vivo experiment performed by Inubushi et al (2013), osteoclasts located along the bone surface were otherwise increased after LIPUS application in one of the experimental groups.…”

Section: Discussionsupporting

confidence: 74%

“…Alternatively, few studies have recently presented evidences supporting the assumption that low-intensity pulsed ultrasound (LIPUS) might as well accelerate orthodonticaly-induced tooth movement (El-Bialy, Lam, Aldaghreer, & Sloan, 2011;Inubushi et al, 2013;Al-Daghreer et al, 2014). Histological findings demonstrated increased alveolar bone remodeling due to the elevated number of osteoclast (OC) cells along the bone surfaces of the moved teeth that were subjected to ultrasound application (ElBialy et al, 2011;Inubushi et al, 2013;Xue et al, 2013;Al-Daghreer et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Histological findings demonstrated increased alveolar bone remodeling due to the elevated number of osteoclast (OC) cells along the bone surfaces of the moved teeth that were subjected to ultrasound application (ElBialy et al, 2011;Inubushi et al, 2013;Xue et al, 2013;Al-Daghreer et al, 2014). The LIPUS-driven increase in the OC number might be attributed to the stimulation of their differentiation as a result of an upregulation of the RANK-L gene expression in osteoblasts (Inubushi et al, 2013;Xue et al, 2013), which generates the most important mediator for osteoclastogenesis (Titorencu, Pruna, Jinga, & Simionescu, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Effect of low-intensity pulsed ultrasound on the activity of osteoclasts: An in vitro study

Feres

Kucharski

Diar-Bakirly

et al. 2016

Archives of Oral Biology

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Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of low-intensity pulsed ultrasound on the activity of osteoclasts: An in vitro study

Feres

Kucharski

Diar-Bakirly

et al. 2016

Archives of Oral Biology

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“…This may be due to the anabolic effect of LIPUS on cementoblasts that either helped repair RL or stimulated secretion of a protective cementum layer against OIRR. 16,23,24,29 In addition, it has been demonstrated that LIPUS can inhibit osteoclast activity by decreasing the Receptor activator of nuclear factor kappa-B ligand/Osteoprotegerin (RANKL/OPG) ratio. 23,24,30 This could also be due to the anti-inflammatory effect of LIPUS, 31 as it has been reported to decrease the tumor necrosis factor-a or interleukin-1b 31 that are also involved in the proliferation and differentiation of odontoclast cells.…”

Section: Discussionmentioning

confidence: 99%

Effect of low-intensity pulsed ultrasound on orthodontically induced root resorption caused by torque: A prospective, double-blind, controlled clinical trial

Raza

Major

Dederich

et al. 2015

The Angle Orthodontist

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Objectives: To evaluate the effects of low-intensity pulsed ultrasound (LIPUS) on orthodontically induced tooth root resorption caused by torque in human subjects. Materials and Methods: Ten healthy patients (12-35 years of age) who required extraction of all first premolars as a part of their routine orthodontic treatment were recruited. A 15u twist was applied in the arch wire using 0.019 3 0.025-inch TMA in a 0.022-inch bracket system (Synergy R) that produced a buccal root torque of approximately 5 N/mm at the bracket level. Using a split mouth design, randomization, and blinding, one side of the arch received LIPUS for 20 minutes per day for 4 weeks at an incident intensity of 30 mW/cm 2 of the transducers' surface area. The other side served as a self-control, which received a sham transducer. After 4 weeks, all first premolars were extracted and micro-computed tomographic analysis was performed on these extracted teeth. A linear mixed-model statistical analysis was used. Results: LIPUS-treated teeth showed significantly less total volume of resorption lacunae compared to control teeth by a mean difference of (0.54 6 0.09 mm 3 ) (P , .001) and percentage of root resorption by a mean difference of (0.33 6 0.05 mm 3 ) (P , .001). In addition, significantly fewer resorption lacunae were found on all root surfaces in the LIPUS group compared to the control except in the instance of the distal surface. Limitations: This study was performed on limited number of cases during a 4-week period. Conclusions: LIPUS minimizes root resorption when applied during torque tooth movement over a 4-week period. (Angle Orthod. 2016;86:550-557.)

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“…Also, LIPUS effects on osteoblasts and enhancement of angiogenesis [19,20] were reported. Some studies showed that LIPUS enhanced cell expansion and differentiation in tissue culture [10,21,22]. However, the underlying molecular mechanisms governing these LIPUS-induced effects on tissues and cells [4,5] still need to be investigated.…”

Section: Introductionmentioning

confidence: 99%

Effects of Low Intensity Continuous Ultrasound (LICU) on Mouse Pancreatic Tumor Explants

et al. 2017

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This paper describes the effects of low intensity continuous ultrasound (LICU) on the inflammatory response of mouse pancreatic tumor explants. While there are many reports focusing on the application of low-intensity pulsed ultrasound (LIPUS) on cell cultures and tissues, the effects of continuous oscillations on biological tissues have never been investigated. Here we present an exploratory study of the effects induced by LICU on mouse pancreatic tumor explants. We show that LICU causes significant upregulation of IFN-γ, IL-1β, and TNF-α on tumor explants. No detectable effects were observed on tumor vasculature or collagen I deposition, while thermal and mechanical effects were not apparent. Tumor explants responded as a single unit to acoustic waves, with spatial pressure variations smaller than their size.

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Effect of Low-Intensity Pulsed Ultrasound on Orthodontically Induced Root Resorption in Beagle Dogs

Cited by 46 publications

References 26 publications

Effect of low-intensity pulsed ultrasound on the activity of osteoclasts: An in vitro study

Effect of low-intensity pulsed ultrasound on the activity of osteoclasts: An in vitro study

Effect of low-intensity pulsed ultrasound on orthodontically induced root resorption caused by torque: A prospective, double-blind, controlled clinical trial

Effects of Low Intensity Continuous Ultrasound (LICU) on Mouse Pancreatic Tumor Explants

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