Effect of low level laser and low intensity pulsed ultrasound therapy on bone remodeling during orthodontic tooth movement in rats

Alazzawi, Mohammed Mahmood Jawad; Husein, Adam; Alam, Mohammad Khursheed; Hassan, Rohayanti; Shaari, Rumaizi; Ahmad, A.L.; Salzihan, M.S.

doi:10.1186/s40510-018-0208-2

Cited by 37 publications

(28 citation statements)

References 35 publications

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“…It was also reported that RANKL expression in a rat tooth movement model increased compared to the control group following lowpower laser irradiation. 25 The results of the present study were similar, with RANKL gene expression significantly higher in the 2.0 W group 24 hours after Nd: YAG laser irradiation. Our experiments also demonstrated that the RANKL/OPG ratio was higher than that of the control group 24 hours after laser irradiation.…”

Section: Discussionsupporting

confidence: 82%

Examination of the Effect of the Combined Use of Nd: YAG Laser Irradiation and Mechanical Force Loading on Bone Metabolism Using Cultured Human Osteoblasts

et al. 2020

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Introduction: In recent years, laser irradiation in the near-infrared ray (NIR) area has been reported to promote bone healing. There are also reports that laser irradiation accelerates orthodontic tooth movement. In this study, we investigated the effect of NIR laser irradiation and mechanical stimulation on osteoblasts. Methods: We seeded osteoblast-like cells and laser irradiation was performed 24 hours after cell seeding. In addition, a control group not receiving anything, a group receiving only Nd: YAG (neodymium-doped yttrium aluminum garnet) laser irradiation, a group receiving only centrifugal loading, and a group receiving both Nd: YAG laser irradiation and centrifugal force loading were set, and after 24 hours and after 48 hours, cells were collected and quantitative real-time polymerase chain reaction (PCR) was performed. Results: 24 hours after laser irradiation, the gene expression of alkaline phosphatase (ALP), the receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) was significantly higher in the 2.0 W group than in the control group. In addition, the RANKL/OPG ratio was higher in the 2.0 W group than in the control group. Also, in the group using laser irradiation and centrifugal loading in combination, 24 hours after laser irradiation, ALP and OPG showed significantly higher values than those in the centrifugal load only group. Furthermore, the RANKL/OPG ratio also showed high values. Conclusion: These results suggest that osteoblast-like cells activate genes related to bone metabolism by combining mechanical stimulation and laser irradiation. This helps to elucidate the influence of laser irradiation during tooth movement.

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Section: Discussionsupporting

confidence: 82%

Examination of the Effect of the Combined Use of Nd: YAG Laser Irradiation and Mechanical Force Loading on Bone Metabolism Using Cultured Human Osteoblasts

et al. 2020

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“…IL-1b expression was significantly higher in the 660 and 830 nm groups than in the control group on day 3, and the number of osteoclasts was significantly higher in the 660 and 830 nm groups than in the control group. This result indicates that 660 and 830 nm PBM can increase the expression of IL-1b to accelerate the rate of alveolar bone remodeling on the compression side, as reported in previous studies, 17,18 which also confirmed that PBM affects the proliferation and activation of some cells. [19][20][21][22] Especially, on days 3 and 5, the number of osteoclasts in the 660 nm group was higher than that in the 830 nm group, and the difference was statistically significant.…”

Section: Resultssupporting

confidence: 88%

Comparative Study of 660 and 830 nm Photobiomodulation in Promoting Orthodontic Tooth Movement

Yang

2019

Photobiomodulation, Photomedicine, and Laser Surgery

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Objective: Photobiomodulation (PBM) can usefully promote wound healing and relieve pain via its biological effects, with a wide range of applications in clinical medicine. The aim of the present study was to investigate the effect of 660 and 830 nm PBM on orthodontic tooth movement. Background data: PBM is based on the biological effects of diode laser irradiation on tissues, promoting cell proliferation and activity. Materials and methods: An orthodontic force was applied to the upper right first molars exposed to a 660 and 830 nm PBM (LHH-500I; Beijing Long Hui Heng Medical Science and Technology Development Corporation) on days 0, 1, 2, 3, 4, 5, and 7 for 50 sec with power density of 0.1 W/cm 2 (a beam area of 0.5 cm 2 , radiate power of 0.05 W), energy density of 5 J/cm 2 within 14 days, and a control group with no laser irradiation. Tooth movement was analyzed using a stereomicroscope, the number of osteoclasts determined by tartrate-resistant acid phosphatase (TRAP), and the expression of bone remodeling factors evaluated by immunohistochemistry. Results: The expression of IL-1b, RANKL, and OPG was significantly stimulated in the 660 and 830 nm groups. The expression of RANKL was significantly higher in the 660 nm group than in the 830 nm group on days 5 and 7; however, there was no significant difference in the expression of OPG and IL-1b between the 660 and 830 nm groups on days 1, 2, 3, 4, 5, 7, and 14. On days 3 and 5, the number of osteoclasts in the 660 nm group was higher than that in the 830 nm group, and the difference was statistically significant. Tooth movement over 14 days was significantly higher in the 660 and 830 nm groups than in the control group, and there was no significant difference between the 660 and 830 nm groups finally. Conclusions: Both 660 and 830 nm can accelerate the orthodontic tooth movement and promote alveolar bone remodeling on the compression side. Although the difference of tooth movement over 14 days between the two groups was not statistically significant; however, 660 nm PBM to accelerate bone remodeling is stronger than 830 nm PBM at an early stage.

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“…LLLT incites vascularization of the bone defect, fracture position, as well as osteoblasts, which can assist the recuperation of hard tissue. 40 Several reports 41,42 have demonstrated that LLLT could accelerate tooth motion in animals. Some researchers used clinical trials to assess the effect of LLLT on the speed of OTM, but the findings were divergent.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Low-Level Laser Therapy on the Acceleration of Orthodontic Tooth Movement

2020

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In clinical practice, low-level laser therapy (LLLT) is widely used. The main aim of this review is to assess the effectiveness of LLLT in accelerating tooth movement in human subjects. The PRISMA checklist was utilized as a guideline to carry out this systematic review. The electronic databases were searched from Google Scholar (2014-2018) and PubMed, and comprehensive research on this topic was also manually conducted. Therefore, 77 articles randomized clinical trials (RCTs) or controlled clinical trials (CCTs) were selected. After screening studies, consequently, eleven trials met the inclusion criteria. Eight out of 11 studies showed LLLT has a significant impact on the acceleration of orthodontic tooth movement, and there was no statistically significant difference in the rate of tooth movement between the laser group and the control group in the two remaining studies. Furthermore, five out of 11 articles showed that LLLT has no adverse effects. Although we have some degree of understanding from a cellular point of view to LLLT effects, we still do not know whether these cellular level changes have any effect on the clinical acceleration of orthodontic tooth movement. The results are inconclusive and cannot be generalized to the public community; therefore, well-structured studies are required.

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Effect of low level laser and low intensity pulsed ultrasound therapy on bone remodeling during orthodontic tooth movement in rats

Cited by 37 publications

References 35 publications

Examination of the Effect of the Combined Use of Nd: YAG Laser Irradiation and Mechanical Force Loading on Bone Metabolism Using Cultured Human Osteoblasts

Examination of the Effect of the Combined Use of Nd: YAG Laser Irradiation and Mechanical Force Loading on Bone Metabolism Using Cultured Human Osteoblasts

Comparative Study of 660 and 830 nm Photobiomodulation in Promoting Orthodontic Tooth Movement

The Effect of Low-Level Laser Therapy on the Acceleration of Orthodontic Tooth Movement

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