Effect of &lt;i&gt;Manasamitra vatakam&lt;/i&gt;, an Ayurvedic Formulation, on Aluminium-Induced Neurotoxicity in Rats

Thirunavukkaras, SV; Upadhyay, Lata Sheo Bachan; Venkataraman, Satchi

doi:10.4314/tjpr.v11i1.10

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…In the present study, time course monitoring of memory and learning tests of control animals verifies the development of spatial learning and memory, however, active learning was significantly impaired in Alzheimer's model group which manifested by increasing latencies in MWM associated with increasing reentry frequency of the animals and prolongation of completion time in radial arm maze, adding to shorten latencies to enter shocking compartment in passive avoidance. The recorded negative effects of AlCl 3 on memory and learning functions in the current study concur with the results of Thirunavukkarasu et al (27). These findings harmonized with marked neuronal loss and vacuolated cytoplasm proved by histopathological study of frontal cortex and hippocampus of Alzheimer's model rats.…”

Section: Discussionsupporting

confidence: 92%

“…Antiinflammatory and antioxidant agents began to improve the performance of the Alzheimer model rats on day 30, which verifies the ability to retain and retrieve information after treatment with both agents (29,30). Anti-inflammatory Cilostazol can protect against cognitive impairment induced by intracerebroventricular injection of Aβ (25)(26)(27)(28)(29)(30) in C57BL/6J mice (31) as well as in human patients with AD (32).…”

Section: Control Alzheimer Modelmentioning

confidence: 99%

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Inflammation versus oxidative stress in pathophysiology of alzheimer's disease in rat model

Ahmed

Thabet

Mohamed

2014

Ibnosina Journal of Medicine and Biomedical Sciences

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Background: Alzheimer's disease (AD) is a highly debilitating neurodegenerative disorder characterized by cognitive dysfunction. Inflammation and oxidative stress are thought to play major roles in the pathophysiology. Which one has the principle role is unclear. Objectives: The role of brain growth factors, cytokines and oxidative biomarkers in cognitive dysfunction induced by Aluminium chloride (AlCl 3) in rats with application of an anti-inflammatory (Cilostazol) and an antioxidant (N-acetyl cysteine, NAC) were investigated to clarify the predominant pathophysiological mechanism involved. Methods: Alzheimer's model group was given AlCl 3 (100 mg/kg) orally for six weeks. Alzheimer's model + NAC, and Alzheimer's model + Cilostazol groups were given (NAC) and Cilostazol respectively one hour before AlCl 3 for the same duration. Results: Anti-inflammatory or antioxidant interventions significantly improved memory retention, which was evaluated by Morris Water Maze, passive avoidance task, and eight-arm radial maze. This improvement was consistent with histological recovery and was mediated by reduction AlCl 3 concentration in the brain hippocampus and frontal cortex, interference with the cholinergic dysfunction, as well as prevention of oxidative damage. In addition, anti-inflammatory agents can modulate superiorly the inflammatory response via reduction of the levels of inflammatory cytokines and adjustment of the levels of brain-derived neurotrophic factors and transforming growth factor B. Conclusions: These finding support the principal role of inflammation in pathophysiology of AD and suggests the potential therapeutic application of anti-inflammatory agents for this condition.

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Section: Discussionsupporting

confidence: 92%

Section: Control Alzheimer Modelmentioning

confidence: 99%

Inflammation versus oxidative stress in pathophysiology of alzheimer's disease in rat model

Ahmed

Thabet

Mohamed

2014

Ibnosina Journal of Medicine and Biomedical Sciences

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“…The comparative study with the standard drug DPZ indicates the effectiveness of MMV in the treatment of neurodegeneration-induced memory impairment. [ 8 9 ] DPZ is effective in inhibiting acetylcholine esterase activity in the nerve synapses, thus facilitating the availability of the neurotransmitter acetylcholine, which in turn helps in memory retention and memory enhancement. The positive roles of MMV in effectively ameliorating the negative effect of the treatment of scopolamine in an experimental rat model depict that MMV plays a vital role in enhancing the neurotransmitter involved in retention of memory.…”

Section: R Esults and Discussionmentioning

confidence: 99%

Manasamitra Vatakam on Scopolamine-Induced Amnesia in Female Wistar Rats

Sankar,

Kandasamy,

Jones

et al. 2024

Journal of Pharmacy and Bioallied Sciences

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Background: Neurodegenerative diseases induce amnesia, and effective treatment is still elusive. Aims and Objectives: The present study highlights the ameliorating effects of Manasa Mitra Vatakam (MMV) using behavioral parameters on scopolamine-induced memory loss in female Wistar rats. Materials and Methods: MMV was compared with DPZ as a standard in the present study to determine the behavioral parameters through elevated plus maze (Hebb William maze/rectangular maze)and locomotor activity in scopolamine-induced memory loss in female Wistar rats. Results and Discussion: The results of the study illustrate the effectiveness of MMV in reversing memory dysfunction and memory-enhancing effects. Conclusion: The study paves the way for exploring research in CNS disorders and its potential application in drug-induced neurotoxicity.

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Therapeutic impact of grape leaves polyphenols on certain biochemical and neurological markers in AlCl3-induced Alzheimer’s disease

Borai

Ezz

Rizk

et al. 2017

Biomedicine & Pharmacotherapy

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Effect of <i>Manasamitra vatakam</i>, an Ayurvedic Formulation, on Aluminium-Induced Neurotoxicity in Rats

Cited by 7 publications

References 15 publications

Inflammation versus oxidative stress in pathophysiology of alzheimer's disease in rat model

Inflammation versus oxidative stress in pathophysiology of alzheimer's disease in rat model

Manasamitra Vatakam on Scopolamine-Induced Amnesia in Female Wistar Rats

Therapeutic impact of grape leaves polyphenols on certain biochemical and neurological markers in AlCl3-induced Alzheimer’s disease

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