Effect of Luteolin on the Levels of Glycoproteins During Azoxymethane-induced Colon Carcinogenesis in Mice

Signal Transducer and Activator of Transcription 3 - A Promising Target in Colitis-Associated Cancer

“…In addition, AOM-induced CRC appears to follow the concept in which tumor initiation is followed by tumor promotion and progression in a sequential manner. Specifically, AOM induces the onset of ACF, as the precursor lesion and Mucin depleted foci (Ashokkumar and Sudhandiran, 2008;Norazalina et al, 2010;Pandurangan et al, 2012) followed by the onset of adenocarcinoma (Ashokkumar and Sudhandiran, 2011;Shafie et al, 2013) most often of the distal colon, and, finally, metastasis to mesenteric lymph nodes and liver (Reddy, 2004).…”

“…Despite of the familial basis of CRC, environmental factors such as food-borne mutagens, chronic intestinal inflammation, specific intestinal commensals and pathogens, leads development of CRC. Chemically-induced cancer models are very useful in understanding the consequences of colon cancer in rodents (Ashokkumar and Sudhandiran, 2008;Pandurangan et al, 2012;Pandurangan et al, 2013;Shafie et al, 2013). A myriad of signaling events were altered during the progression of the colon cancer was reported (Pandurangan, 2013).…”

Dietary Non-nutritive Factors in Targeting of Regulatory Molecules in Colorectal Cancer: An Update

“…Several epidemiological studies have indicated the influence of lifestyle factors, particularly nutritional factors, on the development of certain forms of cancers, including the colon carcinomas (Thun et al, 1991;Giovannucci et al, 1995;Yazan et al, 2013). Epidemiological studies have indicated that CRC is strongly associated with diet (Slattery et al, 1999), and thus it may be possible to prevent the occurrence of this cancer by dietary modifications (Ashokkumar and Sudhadiran, 2008;Tanwar et al, 2009;Pandurangan et al, 2012;Pandurangan and Ganapasam, 2013). Pandurangan, (2013) reported that dietary factors can able to modify the oncogenic signaling pathways in colon cancer.…”

Luteolin, a Bioflavonoid Inhibits Colorectal Cancer through Modulation of Multiple Signaling Pathways: A Review

“…Its levels are high in tumor tissue due to increased lipid peroxidation resulting in lowered antioxidant status (Ashokkumar and Sudhandiran, 2008) and aberrant glycosylation (Hakomori, 1996). Pandurangan et al (2012) reported that luteolin have the ability to control glycoproteins such as hexose, hexosamine, fucose and sialic acid in AOMinduced CRC. The multiple action of Luteolin on different models of colon cancer was represented in Table 1.…”