Effect of lysine-acetylsalicylate and phenylbutazone premedication on the protein content of secondary aqueous humour in the dog

Régnier, A.; Bonnefoi, M.; Lescure, Francis

doi:10.1016/s0034-5288(18)31923-4

Cited by 9 publications

(15 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results also indicated that BMZ would not be effective in reducing BAB breakdown. We found that the primary AH protein concentrations at baseline in all three groups were 2‐5 times higher than those previously reported for this model . Our method of protein measurement was different from those previously reported, which may have led to these results …”

Section: Discussioncontrasting

confidence: 88%

“…Prostaglandins mainly mediate BAB dysfunction secondary to surgical trauma in humans, rabbits, and dogs . Additionally, PG production in AH also causes miosis and transient intraocular hypertension .…”

Section: Discussionmentioning

confidence: 99%

“…Prostaglandin E 2 (PGE 2 ) is considered a major mediator involved in BAB breakdown in this model . Therefore, systemic or topical administration of corticosteroids and nonsteroidal anti‐inflammatory drugs (NSAIDs), inhibitors of PG synthesis, before paracentesis has been reported to greatly prevent increased BAB permeability in dogs . Conversely, to our knowledge, there are no experimental data documenting their inhibiting effects on ocular inflammation when they are applied after anterior chamber paracentesis in dogs.…”

Section: Introductionmentioning

confidence: 96%

See 2 more Smart Citations

Comparison of early posttreatment effects of two steroidal anti‐inflammatory ophthalmic drugs on the ocular inflammatory response induced by paracentesis in healthy canine eyes

Sato

Iwasaki

Nagai

et al. 2019

Veterinary Ophthalmology

View full text Add to dashboard Cite

Objective We investigated the early posttreatment effects of two steroidal anti‐inflammatory ophthalmic drugs on blood‐aqueous barrier (BAB) breakdown by paracentesis in dogs. Animal studies We studied 21 healthy beagles with normal eyes. Procedures Controlled anterior chamber paracentesis (0.5 mL) was performed in one eye of each dog. Control group dogs (n = 7) received no medication, whereas those in the treatment groups received a topical anti‐inflammatory medication (difluprednate [DFBA] ophthalmic emulsion 0.05% [n = 7] or betamethasone [BMZ] sodium phosphate ophthalmic solution 0.1% [n = 7]) at 0, 15, 30, and 45 minutes after initial paracentesis in the paracentesed eyes. Secondary aqueous humor (AH) was collected 60 minutes after initial paracentesis. Protein and prostaglandin E2 (PGE2) concentrations in AH were determined using the bicinchoninic acid assay and commercially available immunoassay kit, respectively. All mean values in the three groups were compared using analysis of variance followed by Tukey's post hoc test. Results Aqueous protein and PGE2 concentrations were markedly increased at 60 minutes following paracentesis. Both concentrations in the secondary AH of the DFBA group were significantly lower than those of the control group; however, treatment with BMZ had no significant effects. Conclusions Early postparacentesis treatment with DFBA was more effective than that with BMZ for reducing aqueous protein and PGE2 contents in dogs with paracentesis‐induced BAB breakdown. DFBA may be an appropriate treatment during the early stage of anterior uveitis caused by intraocular surgery in dogs.

show abstract

Section: Discussioncontrasting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

See 1 more Smart Citation

Comparison of early posttreatment effects of two steroidal anti‐inflammatory ophthalmic drugs on the ocular inflammatory response induced by paracentesis in healthy canine eyes

Sato

Iwasaki

Nagai

et al. 2019

Veterinary Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Rich 2 proposed that this immediate increase was the result of a combination of rapid aqueous humor production and water‐tight wound closure. Other possible hypotheses included trabecular meshwork swelling, aqueous outflow obstruction by zonular fragments, the action of visco‐elastic agents, residual lens particles, inflammatory debris, soluble lens proteins, pigment or viscous aqueous or vitreous plasmoid humor 1,2,5,9, 10,18–20 . The use of visco‐elastic agents during cataract surgery was widely incriminated in the acute postoperative IOP increase.…”

Section: Discussionmentioning

confidence: 99%

“…Other possible hypotheses included trabecular meshwork swelling, aqueous outflow obstruction by zonular fragments, the action of visco-elastic agents, residual lens particles, inflammatory debris, soluble lens proteins, pigment or viscous aqueous or vitreous plasmoid humor. 1,2,5,9,10,[18][19][20] The use of visco-elastic agents during cataract surgery was widely incriminated in the acute postoperative IOP increase. Berson, in 1983, showed that instillation of sodium hyaluronate into the anterior chamber of enucleated human eyes caused a 65% decrease in outflow facility.…”

Section: Discussionmentioning

confidence: 99%

Intraocular pressure development after cataract surgery: a prospective study in 50 dogs (1998–2000)

Chahory

Clerc

Guez

et al. 2003

Veterinary Ophthalmology

View full text Add to dashboard Cite

show abstract

Effect of Flunixin Meglumine on the Breakdown of the Blood-Aqueous Barrier Following Paracentesis in the Canine Eye

Régnier¹,

Whitley²,

Bénard³

et al. 1986

Journal of Ocular Pharmacology and Therapeutics

Self Cite

View full text Add to dashboard Cite

The protein and PGE metabolite content of the aqueous humor from untreated and flunixin meglumine pretreated dogs was determined prior to and after anterior chamber paracentesis. In the untreated dogs the concentrations of protein and PGE" metabolite in aqueous humor were greatly elevated secondary to paracentesis. Intravenously administered flunixin meglumine (1.1 mg/kg or 2.2 mg/kg) significantly reduced these inflammatory parameters, confirming that prostaglandins are involved in the stability of the blood-aqueous barrier by paracentesis in the canine eye. The clinical implication of these results is that intravenous adminstration of flunixin meglumine before intraocular surgery should be considered as an adjunct therapy to reduce intraoperative and postoperative uveitis.

show abstract

Effect of lysine-acetylsalicylate and phenylbutazone premedication on the protein content of secondary aqueous humour in the dog

Cited by 9 publications

References 14 publications

Comparison of early posttreatment effects of two steroidal anti‐inflammatory ophthalmic drugs on the ocular inflammatory response induced by paracentesis in healthy canine eyes

Comparison of early posttreatment effects of two steroidal anti‐inflammatory ophthalmic drugs on the ocular inflammatory response induced by paracentesis in healthy canine eyes

Intraocular pressure development after cataract surgery: a prospective study in 50 dogs (1998–2000)

Effect of Flunixin Meglumine on the Breakdown of the Blood-Aqueous Barrier Following Paracentesis in the Canine Eye

Contact Info

Product

Resources

About