Effect of lysolecithin on gastric mucosal structure and potential difference.

Orchard, R T; Reynolds, K. W.; Fox, Benum W.; Andrews, Robert; Parkins, R. A.; Johnson, A. G.

doi:10.1136/gut.18.6.457

Cited by 40 publications

(5 citation statements)

References 3 publications

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“…The damaging action of lysolecithin [13], bile salts [14] and bile acids [15] have been recognised. Whatever the relative importance of these agents in man, it seems that reflux leads to an essentially chemical injury, which results in destruction of the mucus barrier and directly affects the mu cosa.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Bile Reflux in the Elderly

Safe¹,

Nwose²,

Sheehan

et al. 1993

Gerontology

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Duodenogastric bile reflux is common in postoperative stomach but has been reported in intact stomachs. Spontaneous bile reflux in the elderly has not been studied before. This has been assessed in dyspeptic elderly and young patients. Total bile acid (TBA) levels and pH were measured in the samples of fasting gastric juice. Antral biopsies were taken for histological examination including Helicobacter pylori identification. TBA levels were significantly higher in elderly patients with gastritis in comparison to elderly and young normal groups. Only 10% of elderly patients with gastritis and 7% with gastric ulcer has abnormal TBA ( > 1 mmol/l). There was some correlation between the pH and TBA but a significant proportion of elderly patients has pH > 4 with a normal TBA. TBA levels were not significantly different in H. pylori +ve and H. pylori -ve patients. Nineteen elderly patients had evidence of reactive gastritis. Five of these patients had raised TBA levels with severe H. pylori infection. The remaining 15 patients had normal TBA. These patients were on NSAIDs and 4 of them had H. pylori infection. We conclude that spontaneous bile reflux in the elderly is uncommon. Hypochlorhydria which is observed in the elderly is not caused by alkaline bile reflux. The main cause of reactive gastritis in the elderly is NSAIDs ingestion.

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Section: Discussionmentioning

confidence: 99%

Spontaneous Bile Reflux in the Elderly

Safe¹,

Nwose²,

Sheehan

et al. 1993

Gerontology

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“…20,86 Pancreatic and biliary secretions consist of bile acids, lysolecithin, and trypsin, which can injure the gastric and esophageal mucosa and result in pathology. [87][88][89][90][91] The presence of gastric tubes may facilitate gastric and duodenal reflux, but in healthy adults, neither gastric nor jejunal tubes had an effect on gastric emptying or on duodenogastric reflux. 92 The importance of duodenogastric reflux as it relates to development or progression of UGIB in critical illness has not been elucidated.…”

Section: Duodenogastric Refluxmentioning

confidence: 99%

Upper Gastrointestinal Tract Bleeding in Critically Ill Pediatric Patients

Crill

Hak

1999

Pharmacotherapy

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Similar to adults, children under physiologic stress can develop an imbalance in defensive (mucosal layer, motility) and aggressive (gastric acid, bile salts, enzymes) factors responsible for maintaining a healthy gastrointestinal tract. Hypoxia in the gastrointestinal tract likely disrupts the defensive factors, thereby permitting damage by aggressive factors to upper gastrointestinal epithelium that may progress to stress ulceration and acute upper gastrointestinal tract bleeding (UGIB). The basic pathophysiology may be similar in children and adults; however, differences in the time to developing ulceration, ulcer location, and number of ulcers have been reported. Functional development of the gastrointestinal tract is influenced by disease, gestational and postnatal age, and exposure to and type of enteral feedings, thereby confounding the development and prophylaxis of UGIB in neonates and infants. In addition, pharmacotherapy decisions are often complicated by drug administration issues and adverse effects.

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“…Key Words: Duodenogastric reflux-Gastritis-Gastric ulcer. (15), lysolecithin (16,17) and trypsin (TR) (14--18).…”

Section: Duodenogastric Reflux In Children: Measurement Of Phospholip...mentioning

confidence: 99%

Duodenogastric Reflux in Children

Mouterde,

Foucaud,

Vatier

et al. 1990

J. pediatr. gastroenterol. nutr.

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SummaryThe duodenogastric reflux (DGR) is a suspected cause in some esogastric pathologies in adults: esophagitis, peptic gastric ulcers, stress ulcers, ulcers secondary to drugs, gastric cancer, and gastritis. The toxic substances of the reflux are essentially bile acids, lysolecithin, and trypsin. A number of diagnostic methods have been proposed in the adult. This study suggests a diagnosis technique for DGR in the child. Fasting gastric juice was collected by gastric intubation during 1 h and three substances were measured: phospholipids as markers of biliary reflux, trypsin as a marker of pancreatic reflux, and sialic acid as a marker of the degradation of gastric mucus. The sialic acid enabled us to evaluate some of the toxicity of DGR on the stomach. The study of 49 child subjects permitted us to show the existence, in the normal child, of biliopancreatic markers in the stomach under fasting conditions through a physiological DGR; to define the norms in the child, varying according to three age groups: 0–2 months, 2–12 months, and 1–4 years (the maximum values for an age above 4 years seemed to correspond to those in the adult); and to suggest the existence of a pathological DGR in children with antral gastritis or ulcers.

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Effect of lysolecithin on gastric mucosal structure and potential difference.

Cited by 40 publications

References 3 publications

Spontaneous Bile Reflux in the Elderly

Spontaneous Bile Reflux in the Elderly

Upper Gastrointestinal Tract Bleeding in Critically Ill Pediatric Patients

Duodenogastric Reflux in Children

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