We have compared the appearances of the gastric mucosa at gastroscopy with the histological findings in 130 biopsies from 56 patients. There was a fairly consistent correlation between well recognised appearances and the rnicroscopic findings. When the mucosa appeared abnormal this was nearly always confirmed microscopically but one third of apparently normal mucosa showed gastritis. Antral gastritis which appeared mild on gastroscopy, was deep and often severe on microscopy. Serial sections are necessary to evaluate gastritis effectively.

SUMMARY The effect of lysolecithin (100 mg%) on the guinea-pig gastric mucosa was studied by instilling a solution for 30 minutes, preceded and followed by 100 MN HC1 into 10 total gastric pouches. Ten control animals had HCI throughout. Lysolecithin produced a significant change in transmucosal potential difference, macroscopic erosions, and mucosal damage on histology and electron scanning microscopy. None of these changes was seen in the control animals. This is further evidence that the reflux of lysolecithin from the duodenum is an important factor in causing active gastritis and gastric erosions.

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