Effect of Intragastric Irradiation on Gastric Acidity in the Dog

Fox, Benum W.; Littman, Armand; Grossman, M. I.; Ivy, A. C.

doi:10.1016/s0016-5085(53)80113-7

Cited by 8 publications

(2 citation statements)

References 16 publications

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“…It has therefore been preferred to other procedures described in the literature, such as intragastric ($irradiation ( 5 ) or direct irradiation of the exteriorized stomach (8). The efficiency of the technique used for the production of atrophic gastritis in the intact guinea-pig can be considered satisfactory with regard to the secretion parameters.…”

Section: Discussionmentioning

confidence: 99%

The Effect of X-Irradiation on Gastric Secretion in the Intact Guinea-Pig

Capoferro

1972

Scandinavian Journal of Gastroenterology

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Volume, pH, and total acidity of the basal and of the stimulated gastric secretion were measured in guinea-pigs before, and at appropriate intervals after, x-irradiation to the stomach area. A great reduction of the stimulated acidity and acid output was found. It reached a maximum between the second and the fourth week after irradiation. Thereaftcr the total acidity increased gradually. but, 56 weeks after irradiation, it still remained significantly below the normal (p < 0.05). The volume was lowered to a lesser extent.Scand J Gastroenterol Downloaded from informahealthcare.com by University of Calgary on 02/02/15For personal use only.

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Section: Discussionmentioning

confidence: 99%

The Effect of X-Irradiation on Gastric Secretion in the Intact Guinea-Pig

Capoferro

1972

Scandinavian Journal of Gastroenterology

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“…Although they used small numbers of animals, these in vestigators noted that gastrectomy following exposure could prevent death, an indication that mortality from intragastric �-irradiation is largely attrib utable to effects secondary to local radiation trauma. Smaller doses of in tragastric �-radiation diminished gastric acidity (88). Attempts to detoxify radioactive substances deposited internally have not been especially rewarding.…”

Section: Radiation Toxicitymentioning

confidence: 99%