Effect of magnesium infusion on thoracic epidural analgesia

Gupta, Sanjeev; Mitra, Koel; Mukherjee, Maitreyee; Roy, Suddhadeb; Sarkar, Aniruddha; Kundu, Sudeshna Bhar; Goswami, Anupam; Sarkar, Uday Narayan; Sanki, Prokash; Mitra, Ritabrata

doi:10.4103/1658-354x.76512

Cited by 16 publications

(10 citation statements)

References 15 publications

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“…The use of magnesium sulphate can cause peripheral vasodilation which improves cutaneous circulation thus, decreasing the incidence of shivering. (21) Magnesium also acts as Ca 2+ antagonist and NMDA receptor antagonist. This mechanism of action has also been considered for anti-shivering effect.…”

Section: Original Articlementioning

confidence: 99%

Comparative Study of Dexmedetomidine and Magnesium Sulphate as an Adjuvant to Bupivacaine in Spinal Anesthesia

Singh¹,

Vaibhaw²,

Hasnat³

2015

jebmh

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INTRODUCTION: spinal anaesthesia is a widely used simple anaesthethetic technique providing adequate analgesia and muscle relaxation. Search for an adjuvant providing satisfactory intra and post-operative analgesia is still continuing. This study aims to compare the dexmedetomidine and magnesium sulphate as an adjuvant to spinal anaesthesia. MATERIAL AND METHODS: After obtaining institutional ethical committee approval and written informed consent from patients 90 ASA grade I &II patients of either sex having height between 140-180 cm and weight between 40-90 kg were randomly divided in 3 groups of 30 patients each (n=30). Group C: Received 3.0 ml 0.5% bupivacaine heavy + 0.5 ml NS. Group M: Received 3.0 ml 0.5% bupivacaine heavy + 50 mg MgSO4 diluted to 0.5 ml of NS. Group D: Received 3.0 ml 0.5% bupivacaine heavy 10 +dexmedetomidine 10µg diluted to 0.5 ml NS. RESULTS: onset of sensory and motor block was delayed in Group M as compared to group D and group C. Onset of sensory and motor block in group D was significantly faster as compared to group C and group M. Total duration of sensory anaesthesia, duration of sensory block and duration of motor block was significantly prolonged in group D as compared to group M and group C. Patients were hemodynamically stable in all the groups. There were no incidences of any significant adverse effect in any group. CONCLUSION: intrathecal dexmedetomidine is a better adjuvant to intrathecal bupivacaine because of rapid onset of sensory and motor blockade and prolonged duration of sensory and motor blockade without any potential side effects.

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Section: Original Articlementioning

confidence: 99%

Comparative Study of Dexmedetomidine and Magnesium Sulphate as an Adjuvant to Bupivacaine in Spinal Anesthesia

Singh¹,

Vaibhaw²,

Hasnat³

2015

jebmh

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“…Firstly, we used fixed doses of intrathecal (50 mg) and intravenous (30 mg/kg followed by 10 mg/kg) magnesium administration. Although these doses had been proved to be effective by previous studies [4,7,16,21,22], but we assume that comparing larger doses may produce different results.…”

Section: Discussionmentioning

confidence: 91%

Different routes of co-administration of magnesium sulphate with spinal anesthesia in knee arthroscopy: Randomized controlled trial

Sayed

Hassan

2017

Egyptian Journal of Anaesthesia

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Background: Adequate pain management has a great importance for smooth postoperative recovery, early hospital discharge and early rehabilitation. In this study is we compare between the analgesic effect and possible side effects of different routs of magnesium sulphate administration in cases of spinal anesthesia for knee arthroscopy. Methods: 120 patients scheduled for knee arthroscopy 4 groups (30 patients each): group C received only Bupivacaine intrathecally. group Mg-Sp received 50 mg Mg sulphate with Bupivacaine intrathecally, group Mg-Iv 10 min after intrathecal injection, received intravenous injection of 30 mg/kg Mg sulphate in 100 ml saline over 10 min followed by 10 mg/kg intravenous infusion over one hour and group Mg-Art received intra-articular injection of 800 mg Mg sulphate diluted in 12 ml normal saline (0.9% NaCl) 10 min before the end of surgery. Operative time in minutes, VAS at rest and at passive movement, time to be able to perform knee flexion, time from end of surgery until first requirement of analgesics, analgesic consumption, hemodynamic changes and any possible side effects were recorded. Results: Regarding Time to be able to perform knee flexion, time taken from end of surgery until first analgesic dose and amount of pethidine consumption in first postoperative 24 h, group Mg-Art is significantly better than other groups (P = 0.000) (P = 0.000) (P = 0.000) respectivly. Group Mg-Iv is significantly better than group Mg-Sp and group C as regards time taken from end of surgery until first analgesic dose (P = 0.000) and as regards amount of pethidine consumption in first postoperative 24 h (P = 0.000). VAS at rest and with passive movement in group Mg-Art is significantly lower other groups (P = 0.000). Conclusion: Intraarticular administration of magnesium sulphate is found to be better than Intravenous magnesium and intrathecal in postoperative analgesia.

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“…[ 6 ] IV magnesium also prolongs opioid-induced analgesia while minimising nausea, pruritus and somnolence. [ 11 ] And, epidural magnesium has shown to lower the cumulative dose of local anaesthetic ropivacaine. [ 12 ] Apart from this, epidural magnesium had no effect on the incidence of chronic post-operative pain after video-assisted thoracic surgery.…”

Section: Discussionmentioning

confidence: 99%

Single bolus dose of epidural magnesium prolongs the duration of analgesia in cardiac patients undergoing vascular surgeries

Nagre

Jambure

2017

Indian J Anaesth

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Background and Aims:Magnesium, a physiological antagonist of calcium and N-methyl-d-aspartate, has a role in the prevention of pain in patients undergoing surgery for peripheral vascular diseases with cardiac comorbidities such as ischaemic heart disease and coronary artery disease. The objective of our study was assessment of effects of epidural magnesium in cardiac patients undergoing vascular surgery.Methods:Sixty patients of either sex American Society of Anesthesiologists physical status III undergoing surgeries for peripheral vascular diseases were enrolled. The control group had 30 patients who received levobupivacaine 0.25% 10 ml with fentanyl 50 μg while 30 patients in study group received levobupivacaine 0.25% 10 ml with fentanyl 50 μg and magnesium 100 mg. The primary outcome was duration of analgesia. Sedation score, pain assessment using visual analogue scale (VAS), systolic blood pressure (SBP) and diastolic blood pressure (DBP), heart rate (HR), respiratory rate (RR) and fentanyl consumption were also recorded. Statistical analyses were performed using Minitab 15 statistical software.Results:Both groups were similar demographically and with respect to baseline HR, SBP, DBP and RR. In the study group, compared to the control group, duration of analgesia was 4.17 ± 1.07 h versus 1.55 ± 0.47 h (P < 0.01), sedation score were\ better (P = 0.003) and the VAS scores was lower (P < 0.01).Conclusion:Epidural magnesium, added to levobupivacaine and fentanyl as a single bolus dose effectively prolongs the duration of analgesia in high-risk cardiac patients undergoing peripheral vascular surgery.

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Effect of magnesium infusion on thoracic epidural analgesia

Cited by 16 publications

References 15 publications

Comparative Study of Dexmedetomidine and Magnesium Sulphate as an Adjuvant to Bupivacaine in Spinal Anesthesia

Comparative Study of Dexmedetomidine and Magnesium Sulphate as an Adjuvant to Bupivacaine in Spinal Anesthesia

Different routes of co-administration of magnesium sulphate with spinal anesthesia in knee arthroscopy: Randomized controlled trial

Single bolus dose of epidural magnesium prolongs the duration of analgesia in cardiac patients undergoing vascular surgeries

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