Effect of magnesium sulfate on oxytocin-induced contractility in human myometrium: an in vitro study

Onwochei, Desire N.; Carvalho, José Carlos Almeida; Luca, A.; Kingdom, John; Balki, Mrinalini

doi:10.1007/s12630-017-0867-3

Cited by 7 publications

(4 citation statements)

References 34 publications

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“…16 Additionally, the adverse effects of magnesium sulfate on uterine tone and impaired oxytocin-induced contractility in both oxytocin-naive as well as desensitized myometrium are previously documented. [10][11][12] Despite all the above corroborative data suggesting a lack of adequate uterine tone with magnesium therapy leading to increased PPH, we could locate no investigations regarding its effect on oxytocin dose requirements during cesarean delivery. We located a single trial in which there was a significant increase in oxytocin dose for magnesium-treated women when compared to a placebo-treated group, albeit during vaginal delivery (13.9 ± 9.2 vs 11.0 ± 7.6 mU/min; P = .04).…”

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

“…Magnesium sulfate therapy is recommended for seizure prophylaxis in patients with severe preeclampsia. 9 Magnesium sulfate is a known tocolytic, 10 which inhibits uterine contraction-strength, prolongs contraction-intervals, 11 and also impairs oxytocin-induced contractility. 12 Higher oxytocin requirements during vaginal delivery in patients with preeclampsia receiving magnesium sulfate is known.…”

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confidence: 99%

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Effective Dose of Prophylactic Oxytocin Infusion During Cesarean Delivery in 90% Population of Nonlaboring Patients With Preeclampsia Receiving Magnesium Sulfate Therapy and Normotensives: An Up-Down Sequential Allocation Dose-Response Study

Tyagi

Mohan

Singh

et al. 2021

Anesthesia &Amp; Analgesia

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BACKGROUND: Oxytocin administration during cesarean delivery is the first-line therapy for the prevention of uterine atony. Patients with preeclampsia may receive magnesium sulfate, a drug with known tocolytic effects, for seizure prophylaxis. However, no study has evaluated the minimum effective dose of oxytocin during cesarean delivery in women with preeclampsia. METHODS: This study compared the effective dose in 90% population (ED90) of oxytocin infusion for achieving satisfactory uterine tone during cesarean delivery in nonlaboring patients with preeclampsia who were receiving magnesium sulfate treatment with a control group of normotensives who were not receiving magnesium sulfate. This prospective dual-arm dose-finding study was based on a 9:1 biased sequential allocation design. Oxytocin infusion was initiated at 13 IU/h, on clamping of the umbilical cord, in the first patient of each group. Uterine tone was graded as satisfactory or unsatisfactory by the obstetrician at 4 minutes after initiation of oxytocin infusion. The dose of oxytocin infusion for subsequent patients was decided according to the response exhibited by the previous patient in the group; it was increased by 2 IU/h after unsatisfactory response or decreased by 2 IU/h or maintained at the same level after satisfactory response, in a ratio of 1:9. Oxytocin-associated side effects were also evaluated.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Effective Dose of Prophylactic Oxytocin Infusion During Cesarean Delivery in 90% Population of Nonlaboring Patients With Preeclampsia Receiving Magnesium Sulfate Therapy and Normotensives: An Up-Down Sequential Allocation Dose-Response Study

Tyagi

Mohan

Singh

et al. 2021

Anesthesia &Amp; Analgesia

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“…Magnesium is also well known to have a relaxant effect on uterine muscle and, as such, it is used as a tocolytic agent in preterm labor. Magnesium is also used to prevent leg cramps during pregnancy [53] and as a tocolytic agent in preterm labor due to its relaxant effect on uterine muscle [54]. It seems that, in vitro, the magnesium ion is only strongly efficient at therapeutic concentrations (below 2.5 mM) on the spontaneous pregnant myometrial contractile activity.…”

Section: Discussionmentioning

confidence: 99%

Study of Magnesium Formulations on Intestinal Cells to Influence Myometrium Cell Relaxation

et al. 2020

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Background: Magnesium is involved in a wide variety of physiological processes including direct relaxation of smooth muscle. A magnesium imbalance can be considered the primary cause or consequence of many pathophysiological conditions. The smooth muscle tissue of the uterus, i.e., the myometrium, undergoes numerous physiological changes during life, fundamental for uterine activities, and it receives proven benefits from magnesium supplementation. However, magnesium supplements have poor absorption and bioavailability. Furthermore, no data are available on the direct interaction between intestinal absorption of magnesium and relaxation of the myometrium. Methods: Permeability in human intestinal cells (Caco-2 cells) and direct effects on myometrial cells (PHM1-41 cells) of two different forms of magnesium, i.e., sucrosomial and bisglycinate, were studied in order to verify the magnesium capacity of modulate contractility. Cell viability, reactive oxygen species (ROS) and nitric oxide (NO) production, magnesium concentration, contractility, and pathways involved were analyzed. Results: Data showed a better influence of buffered chelate bisglycinate on intestinal permeability and myometrial relaxation over time with a maximum effect at 3 h and greater availability compared to the sucrosomial form. Conclusions: Magnesium-buffered bisglycinate chelate showed better intestinal absorption and myometrial contraction, indicating a better chance of effectiveness in human applications.

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Gestational and Hormonal Effects on Magnesium Sulfate’s Ability to Inhibit Mouse Uterine Contractility

2020

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Effect of magnesium sulfate on oxytocin-induced contractility in human myometrium: an in vitro study

Cited by 7 publications

References 34 publications

Effective Dose of Prophylactic Oxytocin Infusion During Cesarean Delivery in 90% Population of Nonlaboring Patients With Preeclampsia Receiving Magnesium Sulfate Therapy and Normotensives: An Up-Down Sequential Allocation Dose-Response Study

Effective Dose of Prophylactic Oxytocin Infusion During Cesarean Delivery in 90% Population of Nonlaboring Patients With Preeclampsia Receiving Magnesium Sulfate Therapy and Normotensives: An Up-Down Sequential Allocation Dose-Response Study

Study of Magnesium Formulations on Intestinal Cells to Influence Myometrium Cell Relaxation

Gestational and Hormonal Effects on Magnesium Sulfate’s Ability to Inhibit Mouse Uterine Contractility

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