Effect of magnetic nanoparticles coating on cell proliferation and uptake

Závišová, V.; Koneracká, M.; Gábelová, Alena; Svitkova, Barbora; Ursı́nyová, Monika; Kubovčíková, Martina; Antal, Iryna; Khmara, Iryna; Juríková, Alena; Molčan, Matúš; Ognjanović, Miloš; Antić, Bratislav; Kopčanský, P.

doi:10.1016/j.jmmm.2018.09.116

Cited by 37 publications

(25 citation statements)

References 37 publications

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“…Indeed, the impact of MNPs coating has been suggested an important factor in toxicity of MNPs in A549 cells. 58 We observed here that MNPs with PEG, a synthetic polymer, induced cytokine activation at early time-point and this was progressively increased in the later time-point. MNPs coated with BSA, an albumin occurring naturally in the body, induced inammatory response only at early time-point and later it was attenuated.…”

Section: Discussionmentioning

confidence: 51%

Surface coating determines the inflammatory potential of magnetite nanoparticles in murine renal podocytes and mesangial cells

et al. 2020

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Section: Discussionmentioning

confidence: 51%

Surface coating determines the inflammatory potential of magnetite nanoparticles in murine renal podocytes and mesangial cells

et al. 2020

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“…Another important application of superparamagnetic MNPs is to thermally conduct the ablation of pathological cells, or to induce the thermal release of drugs within composites materials, due to the capacity of heating up when they are in proximity of an alternating magnetic field [199,224,225]. Furthermore, some MNPs, in particular SPIONs, are widely used in magnetic resonance imaging (MRI) as contrast agents [216,226,227] or for the treatment of infectious diseases, due their intrinsic activity as antimicrobial agents [228].…”

Section: Magnetic Responsive Nanomaterialsmentioning

confidence: 99%

Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

Municoy

Echazú

Antezana

et al. 2020

IJMS

155

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Smart or stimuli-responsive materials are an emerging class of materials used for tissue engineering and drug delivery. A variety of stimuli (including temperature, pH, redox-state, light, and magnet fields) are being investigated for their potential to change a material’s properties, interactions, structure, and/or dimensions. The specificity of stimuli response, and ability to respond to endogenous cues inherently present in living systems provide possibilities to develop novel tissue engineering and drug delivery strategies (for example materials composed of stimuli responsive polymers that self-assemble or undergo phase transitions or morphology transformations). Herein, smart materials as controlled drug release vehicles for tissue engineering are described, highlighting their potential for the delivery of precise quantities of drugs at specific locations and times promoting the controlled repair or remodeling of tissues.

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“…As MNPs de magnetita podem ser obtidas de diversas formas tais como coprecipitação química, síntese hidrotérmica, decomposição térmica, micro-ondas, síntese eletroquímica, ultrassom dentre outras, entretanto, a técnica de coprecipitação química de sais de ferro ainda é a mais utilizada em virtude da sua simplicidade e do seu baixo custo. No entanto, devido à grande área superficial e as fortes interações dipolo-dipolo apresentadas pelas nanopartículas magnéticas tornam-se imprescindíveis que suas superfícies sejam funcionalizadas visando melhorar a estabilização, evitar sua aglomeração, bem como aumentar o tempo de circulação no sistema [5,6].…”

Section: Síntese Da Magnetitaunclassified

Influência Do Tempo De Revestimento No Tamanho E Estabilidade De Nanoparticulas De Magnetita Para Tratamentos De Hipertermia Magnética

Paresque¹,

Oliveira²,

Castro³

2019

TMM

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Em tratamentos de hipertermia magnética, as etapas de produção e revestimento das nanopartículas magnéticas são de fundamental importância para sua funcionalidade e eficiência durante a dinâmica do tratamento. O método de coprecipitação vem sendo utilizado para sintetizar nanopartículas de magnetita (Fe 3 O 4), largamente utilizadas neste tratamento. As mesmas foram recobertas com uma camada polimérica de polietilenoglicol (PEG) visando prevenir a oxidação do núcleo, permitir sua dispersão em água, aumentar sua estabilidade coloidal, bem como evitar a aglomeração das nanopartículas. Foram realizadas cinco sínteses, cada uma delas com tempos da etapa de revestimento das nanopartículas de 10, 20, 30, 50 e 60 minutos, respectivamente. Foram avaliadas a influência do tempo de revestimento no tamanho das partículas utilizando Nanoparticle Traking Analysis (NTA) e a estabilidade do revestimento por TGA/DSC. As nanopartículas revestidas apresentaram diâmetros médios na faixa de 31 a 40 nm. Analises no TGA/DSC permitiram observar a presença de uma camada adsorvida na superfície do núcleo magnético, bem como a eficácia do polietilenoglicol na proteção do núcleo de magnetita.

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Effect of magnetic nanoparticles coating on cell proliferation and uptake

Cited by 37 publications

References 37 publications

Surface coating determines the inflammatory potential of magnetite nanoparticles in murine renal podocytes and mesangial cells

Surface coating determines the inflammatory potential of magnetite nanoparticles in murine renal podocytes and mesangial cells

Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery

Influência Do Tempo De Revestimento No Tamanho E Estabilidade De Nanoparticulas De Magnetita Para Tratamentos De Hipertermia Magnética

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