Effect of Magnifera indica Leaf Extract on Paracetamol-induced Hepatic Toxicity in Rats

Maxwell, Ezeja

doi:10.9734/ejmp/2014/10114

Cited by 6 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, there was no significant difference in the serum level of total protein in SCL and the control groups. This may be ascribed to the short duration of the study . In this context, Soufy and colleagues claimed that a significant increase of serum total bilirubin due to exposure to CF may arise from the vast damage of liver cells and/or blockage of the bile duct, which results in the hemolysis or gallbladder enlargement .…”

Section: Discussionmentioning

confidence: 99%

“…This may be ascribed to the short duration of the study. 44 In this context, Soufy and colleagues claimed that a significant increase of serum total bilirubin due to exposure to CF may arise from the vast damage of liver cells and/or blockage of the bile duct, which results in the hemolysis or gallbladder enlargement. 45 In experimental rats, exposure to CF alone increased the total bilirubin level, while treatment with either SCL or silymarin significantly reduced this parameter.…”

Section: ■ Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Protective Role of Syzygium Cymosum Leaf Extract Against Carbofuran-Induced Hematological and Hepatic Toxicities

Wahed

Mondal

Rahman

et al. 2019

Chem. Res. Toxicol.

View full text Add to dashboard Cite

The aim of the present study was to evaluate the protective effect of Syzygium cymosum leaf methanol extract (SCL) against carbofuran (CF)induced hepatotoxicity in Sprague−Dawley rats, along with the identification and quantification of polyphenolic composition by high-performance liquid chromatography (HPLC). Results revealed the presence of alkaloids, tannins, and flavonoids in SCL. Similarly, HPLC analysis suggests that SCL contains some known important antioxidants, such as rutin, benzoic acid, and salicylic acid that could be responsible for the hepatoprotective activity of the extract. In CFexposed rats, significant hematological alterations along with histological changes were marked by the presence of necrosis, congestion, and inflammation. CFintoxication also showed an increase in lipid peroxidation and decrease in cellular antioxidant enzymes (e.g., superoxide dismutase, catalase, and glutathione peroxidase) levels in rats compared with the control group. Furthermore, coadministration of SCL significantly ameliorated the abnormalities and improved the cellular arrangement in experimental animals. SCL also reversed the alteration of hematological and biochemical parameters and brought them back to normal levels as compared to the control group. In conclusion, S. cymosum may be one of the best sources of natural antioxidant compounds that can be used in the treatment of oxidative stress and stress-related diseases and disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Protective Role of Syzygium Cymosum Leaf Extract Against Carbofuran-Induced Hematological and Hepatic Toxicities

Wahed

Mondal

Rahman

et al. 2019

Chem. Res. Toxicol.

View full text Add to dashboard Cite

show abstract

“…Our findings showed no significant alteration in the serum albumin level between the test and control groups. This may be ascribed to the short time period of the experiment …”

Section: Discussionmentioning

confidence: 99%

“…This may be ascribed to the short time period of the experiment. 37 Lipid peroxidation (LPO) is a significant oxidative mechanism for cellular injuries. 38 Oxidative cellular injuries generally arise through generation of ROS ( • OH and H 2 O 2 ) during biochemical reactions.…”

Section: Chemical Research In Toxicologymentioning

confidence: 99%

Hepatoprotective and Antioxidant Activities of Justicia gendarussa Leaf Extract in Carbofuran-Induced Hepatic Damage in Rats

Mondal

Hossain

Rahman

et al. 2019

Chem. Res. Toxicol.

View full text Add to dashboard Cite

In folk medicines, Justicia gendarussa (J. gendarussa) is used as a depurative herb for treating fever, pain, and cancer and as laxative for constipation. The aim of the present investigation was to evaluate the hepatoprotective effect of the leaf methanol extract of J. gendarussa leaf (J gMe) against carbofuran (CF)-intoxicated liver injuries in Sprague−Dawley rats, along with the antioxidant activity of this extract. For this purpose, levels of serum diagnostic markers, hepatic antioxidant enzymes, and liver histoarchitecture were employed to justify the protective efficacy of J gMe. In addition, the phenolic and flavonoid contents of the extract were quantified, and antioxidant activity was investigated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide, hydrogen peroxide, and hydroxyl free radical scavenging assays. Results revealed that the leaf extract caused a significant (<0.05, <0.01) decrease of the level of hepatic enzymes, triglycerides, and bilirubin and an increase of the total protein. J gMe has also significantly (<0.05, <0.01) lowered the level of malonylaldehyde. Carbofuran markedly suppressed hepatic antioxidant enzymes, however, the leaf extract significantly augmented these enzymes. The hepatoprotective effect was demonstrated by the improvement in the histo-architectural features of liver sections of CFintoxicated rats treated with J gMe at 500 mg/kg dose. In addition, J gMe showed moderate total phenolic and total flavonoid content, whereas the IC 50 values of DPPH, nitric oxide, hydrogen peroxide, and hydroxyl free radical scavenging assays were 71.31 ± 0.42, 134.82 ± 0.14, 47.69 ± 0.38, and 118.44 ± 0.30 μg/mL, respectively. In conclusion, the present study suggests the protective role of J gMe against hepatic injury induced by CF, which may be attributed to its higher antioxidant properties and thereby scientifically justifies its traditional use.

show abstract

“…The liver plays a central role in haematopoiesis, synthesis of coagulation proteins, and regulating many important metabolic functions [4]. Liver diseases such as hepatitis, jaundice, cirrhosis and fatty liver are very common and constitute a large public health problem that account for high death rate [5]. Some of these diseases are mainly caused by toxic chemicals, excess consumption of alcohol, infection, among other factors.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effect of Psidium guajava (l.) leaf aqueous extract on aluminium nitrate-induced liver damage in female Wistar rats

2020

View full text Add to dashboard Cite

Background: Aluminium nitrate and other aluminium-containing compounds have been demonstrated to cause several health challenges. Psidium guajava L) is a well known cultivated tree with hepatoprotective nature and radical scavenging ability. Methods: Twenty-five (25) female Wistar rats with average weight of 195 g were grouped into five groups (n = 5), with their weights measured and recorded weekly throughout the period of 21 days of the research. Control (group A), 32.5 mg/kg AL only (group B), 30 mg/kg AL + 250 mg/kg PGLE (group C), 20 mg/kg AL + 500 mg/kg PGLE (group D) and 10 mg/kg AL + 750 mg/kg PGLE (group E). Histological examination of the liver was done using Hematoxylin and Eosin stain. Results: Various degenerative changes were observed in the liver architecture following aluminum nitrate administration when compared with the control group. Significant regenerative changes similar to control were observed following administration of high dose of Psidium guajava. Conclusion: The results obtained in this study revealed that aqueous extract of Psidium guajava leaves possess good hepato-protective properties.

show abstract

Effect of Magnifera indica Leaf Extract on Paracetamol-induced Hepatic Toxicity in Rats

Cited by 6 publications

References 0 publications

Protective Role of Syzygium Cymosum Leaf Extract Against Carbofuran-Induced Hematological and Hepatic Toxicities

Protective Role of Syzygium Cymosum Leaf Extract Against Carbofuran-Induced Hematological and Hepatic Toxicities

Hepatoprotective and Antioxidant Activities of Justicia gendarussa Leaf Extract in Carbofuran-Induced Hepatic Damage in Rats

Ameliorative effect of Psidium guajava (l.) leaf aqueous extract on aluminium nitrate-induced liver damage in female Wistar rats

Contact Info

Product

Resources

About