Effect of malathion on liver ache activity of mice

Wankhade, Varsha; Malu, AR; Pawar, SP

doi:10.4172/0974-8369.1000023

Cited by 2 publications

(3 citation statements)

References 7 publications

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“…In an experimental study conducted to investigate the effect of malathion toxicity on acetylcholinesterase activity in mice, mature mice were exposed to malathion at different doses at different times. It was found that malathion inhibited acetylcholinesterase activity in liver (Wankhade et al, 2009). It was observed that the acetylcholineesterase activity in the MAL group was statistically significantly lower when compared to all other groups (p <0.05) as demonstrated in Table 5.…”

Section: Groupmentioning

confidence: 77%

The effects of royal jelly on oxidative stress and toxicity in tissues induced by malathion, an organophosphate insecticide

Aksoy

Alper

2019

J Hellenic Vet Med Soc

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Royal jelly is a bee product frequently used in pharmaceutical, food and cosmetic industries due to its biological activities. The present study aimed to determine the effects of royal jelly on malathion-induced toxicity and biochemical changes. The rats that were used as experimental animals in the study were divided into 6 groups. Control group rats were administered nothing, while carrier chemicals (1% DMSO) were administered to sham group rats. Malathion group (MAL) rats were injected with 0.8 g/kg malathion in DMSO subcutaneously. Saline solution that included 100 mg/kg royal jelly was administered with gavage to the rats in the royal jelly group (RJ). 100 mg/kg royal jelly was administered to RJ+MAL group rats via gavage 1 hour before the injection of 0.8 g/kg malathion. 100 mg/kg royal jelly was administered to MAL+RJ group rats via gavage 1 hour after the injection of 0.8 g/kg malathion. After the experimental process (24 hours), blood samples were taken from the rats in each group under anesthesia (ketamine+xylazine). MDA, NO, GSH, GPx (glutathione peroxidase), CAT, SOD and AChE activities were determined in blood, liver, kidney and brain tissues. It was found that erythrocyte, liver, kidney and brain MDA (malondialdehyde) concentrations in MAL groups were statistically significantly higher when compared to the other groups (p<0.05). It was observed that GSH (glutathione) concentrations increased in the brain, while they decreased in erythrocyte, liver and kidney in the MAL group when compared to the control and sham groups. CAT (catalase) concentration significantly decreased in erythrocyte, liver, kidney and brain tissues in the MAL group when compared to the control and sham groups (p<0.05). SOD (superoxide dismutase) concentration in the MAL group decreased significantly (p<0.05) when compared to other groups, while SOD concentration increased significantly in the therapy and prevention groups (p<0.05) when compared to the others. It was found that serum acetylcholinesterase (AChE) concentration was significantly lower in the MAL group when compared to sham and control groups (p<0.05). Thus, it was concluded that malathion led to lipid peroxidation and oxidative stress in MDA and NO (nitric oxide) levels and toxicity in AChE activities. It was also determined that royal jelly could be effective against oxidative damage and toxicity. The findings suggested that the antioxidant effect of royal jelly could support the treatment of malathion, which is one of the insecticides that contain organophosphate and could lead to oxidative stress. It is considered that the prophylactic characteristics of royal jelly was more effective on malathion toxicity when compared to therapatic properties.

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Section: Groupmentioning

confidence: 77%

The effects of royal jelly on oxidative stress and toxicity in tissues induced by malathion, an organophosphate insecticide

Aksoy

Alper

2019

J Hellenic Vet Med Soc

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“…Aer that, the Zn and Co supported catalyst was tested for its activity (Table 3 entries 19-24). Then solvents like MeOH, acetonitrile, toluene, DCM, DMF, DMSO and solventfree conditions were used for the reaction (Table 3 entries [25][26][27][28][29][30][31][32][33][34][35]. Aer checking the catalytic activity of various catalysts, the Cu/zeolite-Y catalyst was found to be efficient for this reaction.…”

Section: Optimization Of Reaction Parametersmentioning

confidence: 99%

“…Quinoline derivatives undergo hierarchical self-assembly into a variety of nanostructures and mesostructures with enhanced electronic and photonic functions as well as medicinal applications. 26 Indenoquinoline derivatives showed a wide range of biological activities such as 5-HT-receptor binding activity, 27 anti-inammatory activity and they also act as anti-tumor agents, 28 inhibitors for steroid reductase, 29 acetylcholinesterase inhibitors, 30 show antimycobacterial 31 and antiproliferative activities 32 and act as antimalarials. 33 Also, these compounds serve as the building blocks of many natural-chromophore DNA intercalators such as TAS 103, 34 DACA, 35,36 and NSC 314622, 37 which are currently being used as anticancer drugs.…”

Section: Introductionmentioning

confidence: 99%