Effect of Manganese on Synthesis of Brain Catecholamines in Growing Rats

Abstract

The effect of short‐term exposure of manganese on the synthesis of brain catecholamines in growing rats has been investigated by using two methods, 1) measuring the amount of conversion of 3,5‐3H‐tyrosine to 3H‐labelled dopamine and norepinephrine, and 2) measuring the rate of decline of endogenous dopamine and norepinephrine following inhibition of their synthesis with α‐methyl‐p‐tyrosine. The magnitude of conversion of 3,5‐3H‐tyrosine to 3H‐dopamine and 3H‐norepinephrine in the brain at 60 min after the administration of labelled amino acid to the manganese treated rats (1 mg MnCl2.4H2O/ml of water for 30 days) was significantly greater than observed in control rats. Manganese also increased turnover of dopamine and norepinephrine to a greater extent in the brains of treated animals.

Nutritive values, flavor amino acids, healthcare fatty acids and flesh quality improved by manganese referring to up-regulating the antioxidant capacity and signaling molecules TOR and Nrf2 in the muscle of fish

“…However, there is no information concerning the effects of Mn on the muscle physic properties, antioxidant and the Nrf2 and TOR signaling in animals. In growing rat brain, Mn could influence the synthesis of catecholamine (Chandra & Shukla, 1981). It was reported that one of the catecholamine, epinephrine, could regulate the Nrf2 activity in rat astrocyte (Shih, Erb, & Murphy, 2007).…”