Effect of mangiferin on mRNA expression of transforming growth factor beta in rats with liver fibrosis induced by thioacetamide

Handayani, Dwi; Ulfa, Maryam; Wikanendra, Gregorius Bhaskara; Arozal, Wawaimuli

doi:10.1088/1742-6596/1073/3/032076

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Mangiferin also could protect the liver from iron-induced oxidative damage by increasing the excretion of iron 28 . In addition, mangiferin could reduce the expression of TGF-β mRNA in the liver of thioacetamide-induced hepatic brosis rats, implying that mangiferin may have a bene cial effect to hepatic brosis 29 . In the present study, we showed that mangiferin treatment inhibited liver brosis in CCl4 induced liver injury model with multiple line of evidence.…”

Section: Discussionmentioning

confidence: 98%

Mangiferin relieves CCl4-induced liver fibrosis in mice

Zhang

Liu

Yin

et al. 2022

Preprint

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Background: Hepatic fibrosis is a late stage process of many chronic liver diseases. Blocking the fibrosis process will be beneficial to the treatment and recovery of the diseases. Mangiferin has many biological and pharmacological activities. Recently, it has been reported that mangiferin may relieve tissue fibrosis, including renal, myocardial, pulmonary fibrosis via anti-inflammatory and anti-oxidative effects in animal models. Purpose: Here, we investigate the therapeutic effects of mangiferin on CCl4 induced liver fibrosis and the underlying mechanism in mice. Materials/Methods: Thirty-two male C57BL/6 mice were randomly divided into 4 groups (n = 8 in each group), injected with carbon tetrachloride (10% CCl4) for 8 weeks and oral administrated with mangiferin (50 mg/kg or 100 mg/kg) from fifth week. The serum levels of ALT, AST were analyzed to evaluate liver function, H&E staining and Masson’s trichrome staining were used to assess liver morphology and the degree of liver fibrosis. Quantitative RT-PCR was used to assay the gene expression. Results: Mangiferin alleviated the serum levels of AST, ALT, ALP, TBA and TBIL, reduced liver lesions, prevented hepatic parenchymal necrosis and ameliorated collagen accumulation in the liver of mice. Meanwhile, mangiferin inhibited the expression of inflammatory genes IL-6 and IL-1β, fibrogenic genes α-SMA, TGF-β and MMP-2 and bile acid metabolism genes ABCB4, ABCB11, SULT2A1 in the liver of CCl4-treated mice. Conclusions: Our results suggest that mangiferin could alleviate liver fibrosis in CCl4-treated mice and mango consuming may have beneficial effects to hepatic fibrosis.

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Section: Discussionmentioning

confidence: 98%

Mangiferin relieves CCl4-induced liver fibrosis in mice

Zhang

Liu

Yin

et al. 2022

Preprint

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“…Vimang and mangiferin could protect the liver from iron induced oxidative damage via the increasing iron excretion in the liver 91 . In thioacetamide‐induced hepatic fibrosis rats, mangiferin treatment may lower the mRNA expression of TGF‐β in the liver tissue, suggesting that mangiferin may also be effective on liver fibrosis 70 …”

Section: Anti‐fibrogenesis Properties Of Mangiferinmentioning

confidence: 99%

Mangiferin and organ fibrosis: A mini review

Zhang

Huang

2020

BioFactors

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Fibrosis is the end stage of many chronic diseases, which results in organ function failure and high mortality. Mangiferin is a major constituent in mango and other 16 plants, and has been shown a variety of pharmacological effects, such as antioxidant, antibacterial, anti‐tumor, anti‐inflammation. The emerging evidence has shown that mangiferin can improve renal interstitial fibrosis, pulmonary fibrosis, myocardial fibrosis and hepatic fibrosis through the inhibition of inflammation, oxidative stress and fibrogenesis effects, indicating that mangiferin is promising therapeutic choice for organ fibrosis. The aim of this review is to summarize the therapeutic effects of mangiferin on fibrosis of various organs and the underlying mechanisms.

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Anticancer and anti-inflammatory properties of mangiferin: A review of its molecular mechanisms

Mei

Chen

2021

Food and Chemical Toxicology

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Effect of mangiferin on mRNA expression of transforming growth factor beta in rats with liver fibrosis induced by thioacetamide

Cited by 3 publications

References 16 publications

Mangiferin relieves CCl4-induced liver fibrosis in mice

Mangiferin relieves CCl4-induced liver fibrosis in mice

Mangiferin and organ fibrosis: A mini review

Anticancer and anti-inflammatory properties of mangiferin: A review of its molecular mechanisms

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