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Cardiovascular disease is the highest cause of mortality in Indonesia. One of the factors that causes the disease is low level of health awareness, including healthy lifestyle and health control. Improving public health awareness can be done by providing health education in collaboration with interprofessional health services. A collaboration involving students from various health-related disciplines aims to build good collaboration in the future after the corresponding students become health workers. This study is quasi-experimental. Students from health-related disciplines, especially pharmacy and medical students, were authorized to work directly in health screening and to provide education to the community. Student’s perceptions on the Interprofessional Collaboration (IPC) program were explored through Student Perceptions of Physician-Pharmacist Interprofessional Clinical Education (SPICE) questionnaire, which were given before and after the community project. Among 87 SPICE questionnaires, 78 questionnaires filled in completely were collected from pharmacy and medical students. The results of the questionnaire showed good perceptions before and after activities in the community with mean scores of 4.46 (0.35) and 4.5 (0.37) respectively. Wilcoxon test results found no significant difference on the total SPICE scores before and after the activity (P> .05). One item from the SPICE questionnaire, which was the seventh item related to understanding the role of other professionals in the interdisciplinary team, had a significant increase (P <.05).

Background : Cardiovascular diseases contribute more than 17 million deaths every year with coronary heart disease (CHD) being the greatest contributor. One of the medication that is being used to treat CHD was the organic nitrates but long term usage will cause resistance. L-arginine, a substrate for NO synthase (NOS), shows potential as supplementation to treat CHD for its vasodilative and antioxidative effects which protect the heart against myocardial infarction (MI) without causing resistance in long term. L-citrulline, precursor to L-arginine, serves as a better mean to supplement Larginine due to its greater oral bioavailability. The aim of this study is to find the potential cardioprotective effect of lcitrulline against MI, with focus on antioxidants activity. Method : This study used 24 male wistar rats weighed 190-220 grams which divided to 4 groups. 1st and 2nd group received water while 3rd and 4th group received 300mg/kgBW (low dose) and 600mg/kgBW (high dose) of l-citrulline daily respectively. Treatment were given perorally from day 1 to 6. Induction of MI were done by injecting isoproterenol 85mg/kgBW intraperitoneally on day 4 and 5 for group 2,3 and 4 while 1st group served as sham. Blood pressure and ECG were recorded on day 3 and 6. Subjects were sacrificed on day 6 to collect blood and tissue samples. Samples were processed to measure tissue damage by Haematoxylin-Eosin staining, lactate dehydrogenase (LDH) level and aspartate aminotransferase (AST) level and antioxidants activity by superoxide dismutase (SOD) and catalase activity and glutathione (GSH) level and malonidealdehyde (MDA) level. Results : Isoproterenol injection caused myocardial damage and significantly lowered systolic and diastolic blood pressure, serum SOD activity and tissue GSH level and elevated tissue MDA level on all induced groups (p <0.05). Tissue catalase activity only significantly lowered in 2nd group (p <0.05) while serum AST level only significantly increased in low dose group (p <0.05). There was no significant difference between groups for serum LDH level. Conclusion : This study shows that isoproterenol injection successfully cause myocardial infarction in all induced subjects. l-citrulline supplementation fails to provide cardioprotective effects through its antioxidants activity.

Sleep quality and sleep duration might be more disturbed throughout the pandemic of Covid-19 among health care practitioners (HCPs). It could influence impaired fasting glucose (IFG) and hyperuricemia. Therefore, the objective of this study was to assess the association between sleep with IFG and hyperuricemia among HCPs throughout the pandemic of Covid-19. We conducted a crosssectional study that enrolled 58 HCPs in the tertiary hospital. Self-reported questionnaire related to their sleep quality and duration using the Pittsburg Sleep Quality Index (PSQI) were performed by participants. Fasting plasma glucose (FPG) and uric acid (UA) were examined after 10-12 hours of fasting to define IFG and hyperuricemia. A total of 58 HCPs detected 34.5% had IFG and 24.1% had hyperuricemia. We could not identify any statistically significant participants characteristic based on IFG. HCPs who shift workers were 21.4% hyperuricemia compared to 54.4 non-hyperuricemia (p=0.03). There were no different characteristics according to the quality and duration of sleep, where 72.4% HCPs had good quality and duration of sleep. However, we found that sleep medication used scores were higher in IFG group (0.30 ± 0.57) than non-IFG (0.03 ± 0.16) (p<0.01). This study could not detect a significant relationship between quality and/or duration of sleep, with IFG and hyperuricemia. Shift worker significant associated with hyperuricemia (p<0.05). The association between quality and duration of sleep with IFG and hyperuricemia was not found among HCPs, especially during the Covid-19 pandemic. An alert where the IFG group had high sleep medication used scores, and shift workers had a lower risk of hyperuricemia.