L-citrulline as Potential Supplementation in Protecting against Cardiovascular Disease

Laurentius, Andrea; Wikanendra, Gregorius Bhaskara; Arozal, Wawaimuli; Juniantito, Vetnizah; Instiaty, Instiaty; Cong, Tzeto H

doi:10.1254/jpssuppl.wcp2018.0_po1-2-67

Cited by 2 publications

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“…L-citrulline, C 6 H 13 O 3 N 3 , is a non-protein, neutral, non-essential, alpha-amino acid that also serves as an important metabolite of the urea cycle [23]. L-citrulline has an alphastructured chemical configuration (Figure 1), with a molecular mass of 175.19 Daltons, and high solubility in water [24]. As a non-protein monomer, citrulline does not undergo protein synthesis but rather can occur from post-translational modifications and products of the Golgi body [24].…”

Section: Overview On Citrulline and Quercetinmentioning

confidence: 99%

“…L-citrulline has an alphastructured chemical configuration (Figure 1), with a molecular mass of 175.19 Daltons, and high solubility in water [24]. As a non-protein monomer, citrulline does not undergo protein synthesis but rather can occur from post-translational modifications and products of the Golgi body [24]. Naturally, citrulline is largely concentrated in watermelon (Citrullus lanatus (Thunb.)…”

Section: Overview On Citrulline and Quercetinmentioning

confidence: 99%

“…L-citrulline is essentially biosynthesized through the nitric oxide and the urea cycle, with the urea cycle accounting for ~90% production, and the nitric oxide cycle producing ~10% of L-citrulline [24,33]. Citrulline can be directly formed from L-arginine via the activity of nitric oxide synthase (NOS) enzymes, which exist as constitutive (cNOS) and inducible (iNOS) isoforms [34].…”

Section: Metabolism Of L-citrullinementioning

confidence: 99%

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Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review

et al. 2021

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The importance of gut health in animal welfare and wellbeing is undisputable. The intestinal microbiota plays an essential role in the metabolic, nutritional, physiological, and immunological processes of animals. Therefore, the rapid development of dietary supplements to improve gut functions and homeostasis is imminent. Recent studies have uncovered the beneficial effects of dietary supplements on the immune response, microbiota, gut homeostasis, and intestinal health. The application of citrulline (a functional gut biomarker) and quercetin (a known potent flavonoid) to promote gut functions has gained considerable interest as both bioactive substances possess anti-inflammatory, anti-oxidative, and immunomodulatory properties. Research has demonstrated that both citrulline and quercetin can mediate gut activities by combating disruptions to the intestinal integrity and alterations to the gut microbiota. In addition, citrulline and quercetin play crucial roles in maintaining intestinal immune tolerance and gut health. However, the synergistic benefits which these dietary supplements (citrulline and quercetin) may afford to simultaneously promote gut functions remain to be explored. Therefore, this review summarizes the modulatory effects of citrulline and quercetin on the intestinal integrity and gut microbiota, and further expounds on their potential synergistic roles to attenuate intestinal inflammation and promote gut health.

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Section: Overview On Citrulline and Quercetinmentioning

confidence: 99%

Section: Overview On Citrulline and Quercetinmentioning

confidence: 99%

Section: Metabolism Of L-citrullinementioning

confidence: 99%

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Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review

et al. 2021

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“…It also enhances NO production and in turn suppresses the risk of myocardial oxidative stress. Hence, these seeds may be effective for prevention and treatment of oxidative stress-induced cardiovascular disease [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Nootropic Effects of C. melo and C. lanatus seed extracts

Wahid

Alqahtani

Khan

2020

BioMed Research International

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Dementia and related conditions disturb the ability to perform routine life activities prohibiting a person from making appropriate decisions. Seeds of Cucumis melo and Citrullus lanatus have been investigated extensively for various pharmacological properties; hence, considering the presence of bioactive compounds, it was assumed that these seed extracts may support the functioning of the central nervous system. Thus, the present study was designed to investigate the short-term and long-term memory-enhancing effects of C. melo and C. lanatus seed extracts in mice by the Morris water maze (spatial learning and memory), stationary rod test, and passive avoidance tests (fear-motivated tests). Ethanol extract of both seeds were prepared by standard procedure and given to animals in the doses of 50 mg/kg, 100 mg/kg, and 200 mg/kg. The results were compared to standard drugs diazepam and imipramine given in the doses of 3 mg/kg and 30 mg/kg, respectively. Extracts of both the seeds were found to possess significant memory and cognition-enhancing effects in mice when tested by passive avoidance, stationary rod, and water maze tests. Results demonstrate memory and cognition-enhancing effects of these extracts which may be due to the presence of bioactive compounds in these seeds.

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L-citrulline as Potential Supplementation in Protecting against Cardiovascular Disease

Cited by 2 publications

References 0 publications

Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review

Potential Implications of Citrulline and Quercetin on Gut Functioning of Monogastric Animals and Humans: A Comprehensive Review

Nootropic Effects of C. melo and C. lanatus seed extracts

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