Effect of material geometry on cartilagenous tissue formation in vitro

Bhardwaj, Tajinder; Pilliar, Robert M.; Grynpas, Marc D.; Kandel, Rita A.

doi:10.1002/1097-4636(200111)57:2<190::aid-jbm1158>3.3.co;2-a

Cited by 24 publications

(38 citation statements)

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“…Sponges are porous scaffolds that facilitate cell adhesion. Pore size variation affects cell adhesion, migration and deposition [70]. Meshes can also be made to variable porosities governed by fibre diameter and direction.…”

Section: Scaffoldsmentioning

confidence: 99%

Bioengineering of Articular Cartilage: Past, Present and Future

Felimban

Moulton

et al. 2013

Regen. Med.

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The treatment of cartilage defects poses a clinical challenge owing to the lack of intrinsic regenerative capacity of cartilage. The use of tissue engineering techniques to bioengineer articular cartilage is promising and may hold the key to the successful regeneration of cartilage tissue. Natural and synthetic biomaterials have been used to recreate the microarchitecture of articular cartilage through multilayered biomimetic scaffolds. Acellular scaffolds preserve the microarchitecture of articular cartilage through a process of decellularization of biological tissue. Although promising, this technique often results in poor biomechanical strength of the graft. However, biomechanical strength could be improved if biomaterials could be incorporated back into the decellularized tissue to overcome this limitation.

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Section: Scaffoldsmentioning

confidence: 99%

Bioengineering of Articular Cartilage: Past, Present and Future

Felimban

Moulton

et al. 2013

Regen. Med.

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“…Microstructures should be considered when designed scaffolds for tissue engineering because respective cells recognize structures with dimensions comparable to 13-85 µm. 7,9,21 More specifically, fiber diameter and surface topology were found to affect cell adhesion, proliferation and spreading. Similar results were gained compared other reports.…”

Section: 폴리머 제36권 제4호 2012년mentioning

confidence: 99%

In vivo Bone Regeneration by Using Chitosan Scaffolds with KUSA-A1 Oesteoblast Cells

Lim¹,

Oh²,

Choi³

et al. 2012

Polymer Korea

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For bone regeneration from KUSA-A1 oesteoblast cells (KUSA), chitosan (CS) scaffolds possessing different surface properties, sponge-type (CSS) and nonwoven-type (CSNW), were manufactured. Surface area and pore size of CSNW were larger than those of CSS. On the other hand, the pore volume of CSNW was smaller than that of CSS. Cell attachment evaluation showed CSNW was more adequate then CSS, and this was attributed to the large surface area. For in vivo investigation, KUSA were seeded into CS scaffolds in wells followed by a week of cell culture. Obtained CS scaffolds with KUSA were implanted on the subcutaneous tissue of BALB/C nude mice. After surgery, implanted scaffolds were harvested and assayed by immunological staining. Network stability of CSS was better than that of CSNW, even if CSS scaffolds were destroyed between 4 and 6 weeks. Calcification was observed after 4 and 8 weeks for CSNW and CSS, respectively.

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“…The obtained data suggested that the current scaffold with 400 μm pore size significantly increased ECM synthesis by cultured chondrocytes. Previous studies have shown that the scaffold pore size is highly interconnected with cell proliferation and ECM synthesis in chondrocyte culture [10,37,38]. Nehrer et al [10] clarified the effects of scaffold pore sizes, from 20 to 86 μm, on chondrocyte behavior using collagen sponges.…”

Section: Determination Of Adequate Pore Size For a Novel 3d Scaffold mentioning

confidence: 99%

Chitosan-Based Hyaluronic Acid Hybrid Polymer Fibers as a Scaffold Biomaterial for Cartilage Tissue Engineering

et al. 2010

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An ideal scaffold material is one that closely mimics the natural environment in the tissue-specific extracellular matrix (ECM). Therefore, we have applied hyaluronic acid (HA), which is a main component of the cartilage ECM, to chitosan as a fundamental material for cartilage regeneration. To mimic the structural environment of cartilage ECM, the fundamental structure of a scaffold should be a three-dimensional (3D) system with adequate mechanical strength. We structurally developed novel polymer chitosan-based HA hybrid fibers as a biomaterial to easily fabricate 3D scaffolds. This review presents the potential of a 3D fabricated scaffold based on these novel hybrid polymer fibers for cartilage tissue engineering.

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Effect of material geometry on cartilagenous tissue formation in vitro

Cited by 24 publications

References 0 publications

Bioengineering of Articular Cartilage: Past, Present and Future

Bioengineering of Articular Cartilage: Past, Present and Future

In vivo Bone Regeneration by Using Chitosan Scaffolds with KUSA-A1 Oesteoblast Cells

Chitosan-Based Hyaluronic Acid Hybrid Polymer Fibers as a Scaffold Biomaterial for Cartilage Tissue Engineering

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