SUMMARYThis study analyzed the influence of C-factor, flexural modulus and viscous flow on gap formation in resin composite restorations. Two resin composites, a mini-filled hybrid (P 60) and a nanofilled (Supreme), were used. The flexural modulus was obtained from bar-shaped specimens submitted to three-point bending. Viscous flow was obtained from the difference between the initial and final diameter of resin composite disks submitted to a load of 10 N for 120 seconds. Gap analysis was conducted in three types of cylindrical cavities (C-factor of 1.8, 2.6 and 3.4) that were prepared on the occlusal surfaces of human molars. The gap width at the dentin-resin composite interface was measured using a 3D scanning system (Talyscan 150). The data were analyzed by ANOVA and Student-Newman-Keuls' test, t-test and linear regression analysis (α=0.05). The cavities with C-factor 3.4 presented the highest Gap formation (p<0.0001). The lowest Gap formation was found in cavities restored with Supreme resin composite (p<0.0001). P 60 presented significantly higher flexural modulus and lower viscous flow than Supreme (p<0.0001). Regression analyses detected a significant influence of flexural modulus and viscous flow on gap formation (p<0.05).