Effect of Maternal Dietary Redox Levels on Antioxidative Status and Immunity of the Suckling Off-Spring

Abstract

This study investigates two levels of dietary selenium (Se) and vitamin E in combination on their status in sows and their progeny, and influence on antioxidant status and immunological responses of the piglets at weaning. Female pigs (n = 6) were provided LOW or HIGH antioxidant nutrition (Se and vitamin E) from mating until weaning of their off-spring. The HIGH treatment elevated the concentration of Se (p = 0.015) and α-tocopherol (p = 0.023) in plasma of piglets compared with piglets of the LOW treatment. Treatments also affected the concentrations of milk and sow plasma immunoglobulins. Piglets from sows on the HIGH treatment had increased (p < 0.001) activity of glutathione peroxidase, lower serum levels of C-reactive protein (p = 0.005), haptoglobin (p = 0.05) and albumin (p = 0.05), and the number of white blood cells (p = 0.023) and the ratio of NEU to LYM was lower (p = 0.025) than in piglets from sows on the LOW group. Furthermore, the dietary antioxidant level influenced responses of cytokines (interleukine (IL) 6 (p = 0.007), 12 (p = 0.01) and 18 (p = 0.01)) in piglets’ plasma. In conclusion, improved antioxidant status via dietary maternal provision improves the robustness of the offspring via immunomodulatory mechanisms.

Early-life galacto-oligosaccharides supplementation alleviates the small intestinal oxidative stress and dysfunction of lipopolysaccharide-challenged suckling piglets

“…Newborn piglets are transferred from a relatively sterile and hypoxic placenta to an ambient bacterial and oxygen-rich environment, and are very vulnerable to free radical oxidative damage and pathogen invasion [ 1 , 2 ]. The transition may cause the accumulation of reactive oxygen species (ROS) in piglet intestines [ 3 ]. The suckling piglets are frequently susceptible to the intestinal oxidative stress because their intestines are different from the adult pig intestine, with limited ROS elimination capacity of the immature gut antioxidant defense system [ 3 ].…”

“…The transition may cause the accumulation of reactive oxygen species (ROS) in piglet intestines [ 3 ]. The suckling piglets are frequently susceptible to the intestinal oxidative stress because their intestines are different from the adult pig intestine, with limited ROS elimination capacity of the immature gut antioxidant defense system [ 3 ]. Several studies have been performed to reduce occurrence of oxidative stress by improving gut antioxidant function using different nutritional administrations [ 4 , 5 ].…”

Systematic review of animal-based indicators to measure thermal, social, and immune-related stress in pigs

“…The goal of including the term “vitamin E” was to find studies that measure this metabolite as an indicator of the oxidative stress level in the animals under thermal stress conditions. Vitamin E is the primary antioxidant cell protector [ 57 ], and can be used as an antioxidant supplement in porcine diets to neutralize free radicals and reduce oxidative damage resulting from thermal stress [ 30 , 58 , 59 ].…”

Assessment of the influence on Hypsizygus marmoreus stem waste as a sustainable alternative to corn in Holdobagy geese dietary

“…Mushrooms contain various phenolic compounds, which are generally believed to be related to antioxidant activity (Bayram and Karabacak, 2022;Moazzen et al, 2022), with phenolic compounds in mushrooms reportedly possessing the ability to remove LDL-C (Tang et al, 2016), Mushrooms also contain vitamin C and selenium, which have antioxidant properties (Lauridsen et al, 2021;Rathore et al, 2022). Six antioxidants can be extracted from H. marmoreus (Cai et al, 2020), and polysaccharides extracted from H. marmoreus can improve the antioxidant status by enhancing CAT, SOD, GSH-Px, and T-AOC, and reducing MDA (Liu et al, 2018).…”