Effect of Maximum Dose of Atorvastatin on Inflammation, Thrombogenesis, and Fibrinolysis in High-Risk Patients With Ischemic Heart Disease

Tello, Antonio; Marı́n, Francisco; Roldán, Vanessa; García-Herola, Ana; Lorenzo, S; Climent, Vicente; Teresa, Luis de; Sogorb, Francisco

doi:10.1016/s1885-5857(06)60376-9

Cited by 6 publications

(6 citation statements)

References 53 publications

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“…Indeed, Marín et al showed that statin use prevents the development of atrial fibrillation after cardiac surgery, and this benefit could be related to the effects in MMP system [16]. All these points reflect the importance of the MMP levels in most cardiac disease, and reemphasizes the positive effect of using high statin doses [17].…”

mentioning

confidence: 99%

Effects of atorvastatin 80 mg daily on indices of matrix remodelling in ‘high-risk’ patients with ischemic heart disease

Marín

Roldán

Climent

et al. 2010

International Journal of Cardiology

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confidence: 99%

Effects of atorvastatin 80 mg daily on indices of matrix remodelling in ‘high-risk’ patients with ischemic heart disease

Marín

Roldán

Climent

et al. 2010

International Journal of Cardiology

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“…Furthermore, macrophages were almost absent around the ATVC‐PTMC‐coated AZ31 wire, but were slightly present around the PTMC‐coated AZ31 wire, as seen by the CD68 staining in Figure . The low presence of macrophages is attributed to the anti‐inflammatory effect of AVTC . With and without regulation by ATVC, the vascular remodeling showed different behaviors.…”

Section: Resultsmentioning

confidence: 99%

“…Atorvastatin calcium (ATVC) is a routinely used oral medicine for the treatment of patients with cardiovascular disease . It has been shown to exert ‘pleiotropic effects', such as anti‐inflammatory properties, resistance to thrombosis formation, inhibition of SMC proliferation and migration, and improvement of endothelial function . Furthermore, statins can increase the circulation of endothelial progenitor cells that are involved in vascular repair as well as the activity of endothelial nitric oxide (NO) synthase .…”

Section: Introductionmentioning

confidence: 99%

Atorvastatin Eluting Coating for Magnesium‐Based Stents: Control of Degradation and Endothelialization in a Microfluidic Assay and In Vivo

Wang

Zhao

et al. 2020

Adv Materials Technologies

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While absorbable magnesium (Mg) based vascular stents show promise, more progress is needed to fulfil suitable durability, fast endothelialization, anti‐restenosis, and anti‐inflammation. To design a multifunctional stent, the authors screen a common oral atorvastatin calcium (ATVC) loaded into a surface‐eroding poly(1,3‐trimethylene carbonate) (PTMC) on a Mg alloy material (AZ31 wire) to achieve well‐controllable degradation rate, target drug delivery, and vascular remodeling. Moreover, to reduce cytocompatibility discrepancy between in vitro static culture and in vivo tests for Mg‐based materials, a microfluidic model is developed to mimic the microenvironment of an early‐stage stented vessel for the study of endothelial cell responses to Mg. The PTMC and PTMC‐ATVC coatings effectively reduce degradation rate of the Mg alloy in the static immersion, electrochemical measurement, microfluidic chip, and in vivo tests. The PTMC‐ATVC‐coated wires perform an outstanding growth and migration of endothelial cells in the microfluidic chip at a flow rate of 10 µL min−1, compared with uncoated and PTMC‐coated wires. In vivo rat test, the PTMC‐ATVC coating positively regulate endothelial cells and smooth muscle cells, reduce intimal hyperplasia and inflammation. The target atorvastatin delivery by PTMC coating show a promising dual‐function for improving the durability and early endothelialization of Mg‐based stents.

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“…The median age was 44 (40)(41)(42)(43)(44)(45)(46)(47)(48) years and the vast majority of subjects were men (92%). Of the study cohort, 24.9% showed a normal BMI, 53.6% were overweight and 21.5% were obese.…”

Section: Resultsmentioning

confidence: 99%

“…Among fibrinolytic parameters, the t-PA (r 2 0.235; p 0.001) and PAI-1 antigen (r 2 0.164; p 0.001) levels were also significantly predicted by the models and identified to be independently associ- Control cohort : Data for the control cohort were obtained from a previous article, reference 48) . : Comparisons were performed within the whole cohort among the BMI groups.…”

Section: Discussionmentioning

confidence: 99%

Effects of Body Mass Index on the Lipid Profile and Biomarkers of Inflammation and a Fibrinolytic and Prothrombotic State

Orenes‐Piñero

Pineda

Roldán

et al. 2015

JAT

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Aim:Both an overweight status and obesity are associated with high cardiovascular morbidity and mortality. The aim of this study was to examine the effects of obesity on different underlying mechanisms, i.e. inflammation, fibrinolysis and a prothrombotic state, in a young high-risk population in the Mediterranean area. Methods: The study population included 237 subjects (median age: 44 years). We recorded the presence of cardiovascular risk factors and premature ischaemic heart disease and performed weight stratification using the body mass index (BMI) according to the established World Health Organization (WHO) criteria. We also measured the serum/plasma lipid, fibrinogen, D-dimer, von Willebrand factor, tissue plasminogen activator antigen (t-PA), plasminogen activator inhibitor-1 antigen (PAI-1) and high-sensitivity C-reactive protein (CRP-hs) levels in samples of peripheral blood. Results: The subjects with premature ischaemic heart disease and hypertension had higher BMI values (p 0.01), and the subjects with an increased weight showed an unadjusted detrimental lipid profile, with a proinflammatory, prothrombotic state and abnormal fibrinolytic parameters. According to a multivariate analysis, the HDL-cholesterol (r 2 0.176; p 0.001), t-PA antigen (r 2 0.235; p 0.001), PAI-1 antigen (r 2 0.164; p 0.001) and CRP-hs (r 2 0.096; p 0.019) levels were significantly related to the weight stratification. Conclusions: A high BMI is a common finding in young populations at high risk of cardiovascular disease. In the current study, the patients with an increased BMI demonstrated an unhealthy lipid profile, as well as a proinflammatory and prothrombotic state and abnormal fibrinolytic parameters. J Atheroscler Thromb, 2015; 22: 610-617.

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Effect of Maximum Dose of Atorvastatin on Inflammation, Thrombogenesis, and Fibrinolysis in High-Risk Patients With Ischemic Heart Disease

Cited by 6 publications

References 53 publications

Effects of atorvastatin 80 mg daily on indices of matrix remodelling in ‘high-risk’ patients with ischemic heart disease

Effects of atorvastatin 80 mg daily on indices of matrix remodelling in ‘high-risk’ patients with ischemic heart disease

Atorvastatin Eluting Coating for Magnesium‐Based Stents: Control of Degradation and Endothelialization in a Microfluidic Assay and In Vivo

Effects of Body Mass Index on the Lipid Profile and Biomarkers of Inflammation and a Fibrinolytic and Prothrombotic State

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