Effect of MeJA and Light on the Accumulation of Betulin and Oleanolic Acid in the Saplings of White Birch  (&amp;lt;i&amp;gt;Betula platyphylla&amp;lt;/i&amp;gt; Suk.)

Yin, Jing; Hong-Si, MA; Gong, Yuanyuan; Xiao, Jialei; Jiang, Lichao; Yu, Zhan; Li, Chunxiao; Ren, Chunlin; Yuan-Biao, Yang

doi:10.4236/ajps.2013.412a3002

Cited by 12 publications

(5 citation statements)

References 35 publications

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“…Furthermore, the different light wavelengths were demonstrated to regulate the terpenoid production in the plants through photoreceptors such as cryptochromes or phytochromes [ 5 , 8 ]. Research on white birch reported that blue LEDs had a significant potential to increase triterpenoid production compared with red LEDs [ 43 ]. The differentially expressed genes (DEGs) analysis indicated that blue lights upregulated the expression genes of mevalonic acid pathways such as squalene synthase (SQS), squalene monooxygenase or epoxidase (SQE), and oxidosqualene cyclases (OSCs) whereas those genes under red lights were downregulated [ 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Colored LED Lights: Use One Color Alone or with Others for Growth in Hedyotis corymbosa In Vitro?

Choi

Han

et al. 2022

Plants

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In recent years, light-emitting diode (LED) technology has been applied to improve crop production and induce targeted biochemical or physiological responses in plants. This study investigated the effect of different ratios of blue 450 nm and red 660 nm LEDs on the overall plant growth, photosynthetic characteristics, and total triterpenoid production in the leaves of Hedyotis corymbosa in vitro plants. The results showed that a high proportion of blue LED lights had a positive effect on enhancing photosynthesis and the overall biomass. In addition, blue LED lights were shown to be more effective in controlling the production of the total triterpenoid content compared with the red LED lights. Moreover, it was also found that plants grown under a high proportion of red LEDs exhibited reduced photosynthetic properties and even induced damage to the photosynthetic apparatus, which indicated that the blue or red LED lights played contrary roles in Hedyotis corymbosa.

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Section: Discussionmentioning

confidence: 99%

Colored LED Lights: Use One Color Alone or with Others for Growth in Hedyotis corymbosa In Vitro?

Choi

Han

et al. 2022

Plants

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“…The amount of betulin can be up to 20–30% (or even almost 45%) [ 23 ] of the dry mass of the outer bark, depending on the species of birch (biological species) and its regional location [ 24 , 25 , 26 ]. It has been claimed that much less betulin and related compounds are contained in the root and leaves of birch [ 27 ]. Betulone, erythrodiol, and oleanolic acid may be contained in significantly smaller amounts in birch bark [ 14 , 28 , 29 ].…”

Section: Methods Of Betulin Isolationmentioning

confidence: 99%

Methods of Betulin Extraction from Birch Bark

et al. 2022

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Betulin is the most popular of the known triterpenoids of the lupan series. It has valuable pharmacological properties. It exhibits antibacterial, antiviral, antitumor, hypolipidemic and other types of activity. The prospects of using betulin in medicine, pharmacology, and veterinary medicine require the development of effective methods for obtaining it from waste from the woodworking industry. Therefore, the question arises of the need to develop a technology for isolating and purifying triterpenoids from birch bark in large quantities. This review contains a variety of methods for the isolation of betulin. The advantages and disadvantages of the proposed methods are described. The following methods are considered: vacuum sublimation after preliminary alkaline; vacuum pyrolysis; supercritical extraction with carbon dioxide or mixtures of carbon dioxide with various solvents; extraction with organic solvents. Also, the method of microwave is described, it is activation on the example of the Kyrgyz birch (Betula kirghisorum), this is an endemic species that has not been studied before, growing on the territory of the Republic of Kazakhstan.

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“…is likely influenced by substrates provided by its host. North American A. sinapina is often found on birch known to have high concentrations of betulin [ 21 ], suggesting that it possesses enzymes able to degrade this host, but little is known.…”

Section: Introductionmentioning

confidence: 99%

A First Insight into North American Plant Pathogenic Fungi Armillaria sinapina Transcriptome

Fradj

Montigny

Mérindol

et al. 2020

Biology

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Armillaria sinapina, a fungal pathogen of primary timber species of North American forests, causes white root rot disease that ultimately kills the trees. A more detailed understanding of the molecular mechanisms underlying this illness will support future developments on disease resistance and management, as well as in the decomposition of cellulosic material for further use. In this study, RNA-Seq technology was used to compare the transcriptome profiles of A. sinapina fungal culture grown in yeast malt broth medium supplemented or not with betulin, a natural compound of the terpenoid group found in abundance in white birch bark. This was done to identify enzyme transcripts involved in the metabolism (redox reaction) of betulin into betulinic acid, a potent anticancer drug. De novo assembly and characterization of A. sinapina transcriptome was performed using Illumina technology. A total of 170,592,464 reads were generated, then 273,561 transcripts were characterized. Approximately, 53% of transcripts could be identified using public databases with several metabolic pathways represented. A total of 11 transcripts involved in terpenoid biosynthesis were identified. In addition, 25 gene transcripts that could play a significant role in lignin degradation were uncovered, as well as several redox enzymes of the cytochromes P450 family. To our knowledge, this research is the first transcriptomic study carried out on A. sinapina.

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Effect of MeJA and Light on the Accumulation of Betulin and Oleanolic Acid in the Saplings of White Birch (<i>Betula platyphylla</i> Suk.)

Cited by 12 publications

References 35 publications

Colored LED Lights: Use One Color Alone or with Others for Growth in Hedyotis corymbosa In Vitro?

Colored LED Lights: Use One Color Alone or with Others for Growth in Hedyotis corymbosa In Vitro?

Methods of Betulin Extraction from Birch Bark

A First Insight into North American Plant Pathogenic Fungi Armillaria sinapina Transcriptome

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