Effect of melatonin for the management of endometriosis

Chen, Ping; Zhao, Dong-Xu; Chen, Lei; Su, Cui-Hong; Ji, Yan-Jia; Wang, Dongwei

doi:10.1097/md.0000000000020353

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…For endometriosis patients, two randomized, double‐blinded, placebo‐controlled trials showed contradictory results in the analgesic effect of melatonin (Schwertner et al, 2013; Söderman et al, 2022). To systematize the existing data in the literature, a systematic review and meta‐analysis is in progress (P. Chen et al, 2020).…”

Section: Environmentmentioning

confidence: 99%

Recent insights explaining susceptibility to endometriosis—From genetics to environment

Pais

Almeida‐Santos

2023

WIREs Mechanisms of Disease

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Endometriosis is a disease with a heterogeneous pathogenesis, explained by multiple theories, and also with a polymorphic presentation. The purpose of this literature review is to systematize the genetic, inflammatory, and environmental factors related to the pathophysiology of endometriosis. Current evidence suggests that endometriosis is a complex inherited genetic condition, in which the genes that determine susceptibility to the disease interact with the environment to develop different phenotypes. Genetic variants associated with risk of endometriosis have been identified in several genome‐wide association studies, in addition to a group of genes related to the pathophysiology of endometriosis, namely the estrogen, progesterone and androgen receptors and the cytochrome P450 gene, as well as the p53 gene. The role of inflammation is controversial; however, it is an essential process, both in the initiation and perpetuation of the disease, in and outside the pelvis. Alterations in reactive oxygen species pathways that consequently determine oxidative stress are typical in the inflammatory environment of endometriosis. The role of environmental factors is a relatively new and broad‐spectrum topic, with inconsistent evidence. Multiple factors have been studied such as endocrine‐disrupting chemicals, metals, intrauterine exposure to diethylstilbesterol and lifestyle risk factors. In conclusion, endometriosis remains a mysterious condition, with multifactorial factors involved in its pathophysiology. The progress that has been made in the genetic predisposition to endometriosis may allow the establishment of new therapeutic targets. On the other hand, understanding the role of the environment in this disease may allow preventive intervention, minimizing its incidence and/or severity.This article is categorized under: Reproductive System Diseases > Molecular and Cellular Physiology Reproductive System Diseases > Environmental Factors Reproductive System Diseases > Genetics/Genomics/Epigenetics

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Section: Environmentmentioning

confidence: 99%

Recent insights explaining susceptibility to endometriosis—From genetics to environment

Pais

Almeida‐Santos

2023

WIREs Mechanisms of Disease

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Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs

Ham

Yang

Park

et al. 2022

Journal of Pineal Research

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Endometriosis is a benign gynecological disease characterized by abnormal growth of endometrial-like cells outside the uterus. Melatonin, a hormone secreted by the pineal gland, has been shown to have therapeutic effects in various diseases, including endometriosis. However, the underlying molecular mechanisms are yet to be elucidated. The results of this study demonstrated that melatonin and dienogest administration effectively reduced surgically induced endometriotic lesions in a mouse model. Melatonin suppressed proliferation, induced apoptosis, and dysregulated calcium homeostasis in endometriotic cells and primary endometriotic stromal cells. Melatonin also caused mitochondrial dysfunction by permeating through the mitochondrial membrane to disrupt redox homeostasis in the endometriotic epithelial and stromal cells. Furthermore, melatonin affected oxidative phosphorylation systems to decrease ATP production in End1/E6E7 and VK2/E6E7 cells. This was achieved through messenger RNA-mediated downregulation of respiratory complex subunits. Melatonin inhibited the PI3K/AKT and ERK1/2 pathways and the mitochondria-associated membrane axis and further suppressed the migration of endometriotic epithelial and stromal cells.Furthermore, we demonstrated that tiRNA GluCTC and tiRNA AspGTC were associated with the proliferation of endometriosis and that melatonin suppressed the expression of these tiRNAs in primary endometriotic stromal cells and lesions in a mouse model. Thus, melatonin can be used as a novel therapeutic agent to manage endometriosis.

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Effect of melatonin for the management of endometriosis

Cited by 2 publications

References 19 publications

Recent insights explaining susceptibility to endometriosis—From genetics to environment

Recent insights explaining susceptibility to endometriosis—From genetics to environment

Melatonin inhibits endometriosis development by disrupting mitochondrial function and regulating tiRNAs

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