Effect of melatonin in reducing blood loss during and after caesarean section

Jayashree, V.; Vanathi, R; Baby, Mounirou

doi:10.33545/gynae.2021.v5.i6d.1085

Cited by 2 publications

(4 citation statements)

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“…According to the Cochrane ROB tool 2, two studies had a high risk of bias, two studies had some concerns of bias, and three studies had a low risk of bias ( Figure 2 ). Regarding the randomization process domain, three RCTs [ 36 , 37 , 38 ] were evaluated as having “some concerns” due to missing information about the randomization process. For the deviation from intended interventions domain, two RCTs [ 36 , 38 ] were evaluated as having “some concerns” due to no information about the deviations from usual practice that were likely to impact the outcome.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the randomization process domain, three RCTs [ 36 , 37 , 38 ] were evaluated as having “some concerns” due to missing information about the randomization process. For the deviation from intended interventions domain, two RCTs [ 36 , 38 ] were evaluated as having “some concerns” due to no information about the deviations from usual practice that were likely to impact the outcome. For the missing data domain, one RCT [ 30 ] was evaluated as having a “high” risk of bias due to a high degree of missing data.…”

Section: Resultsmentioning

confidence: 99%

“…For the missing data domain, one RCT [ 30 ] was evaluated as having a “high” risk of bias due to a high degree of missing data. For the measurement of outcomes domains, two RCTs [ 37 , 38 ] were evaluated as having some concerns, and one RCT [ 36 ] was evaluated as having a “high” risk of bias. Moreover, for the selection of the reported results domain, four RCTs [ 30 , 36 , 37 , 38 ] were evaluated as having “some concerns” due to no information available to exclude the possibility that reported outcome data were selected.…”

Section: Resultsmentioning

confidence: 99%

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Efficacy and Safety of Preoperative Melatonin for Women Undergoing Cesarean Section: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials

Albzea,

Almonayea,

Aljassar

et al. 2023

Medicina

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Background: Cesarean section (CS) has been linked to a number of negative effects, such as pain, anxiety, and sleeping problems. The aim of this systematic review and meta-analysis was to investigate the safety and efficacy of preoperative melatonin on postoperative outcomes in pregnant women who were scheduled for elective CS. Methods: We systemically searched 4 electronic databases (PubMed, Scopus, Web of Science, and Cochrane Library) from inception until 10 March 2023. We included randomized controlled trials (RCTs) comparing melatonin and placebo for postoperative outcomes in CS patients. For risk of bias assessment, we used the Cochrane Risk of Bias 2 tool. Continuous variables were pooled as mean difference (MD), and categorical variables were pooled as a risk ratio (RR) with a 95% confidence interval (CI). Results: We included 7 studies with a total of 754 pregnant women scheduled for CS. The melatonin group had a lower pain score (MD = −1.23, 95% CI [−1.94, −0.51], p < 0.001) and longer time to first analgesic request (MD = 60.41 min, 95% CI [45.47, 75.36], p < 0.001) than the placebo group. No difference was found regarding hemoglobin levels, heart rate, mean arterial pressure, total blood loss, or adverse events. Conclusions: Preoperative melatonin may reduce postoperative pain in CS patients without side effects. This research offers a safe and affordable pain management method for this population, which has clinical consequences. Further research is needed to validate these findings and determine the best melatonin dosage and timing.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Efficacy and Safety of Preoperative Melatonin for Women Undergoing Cesarean Section: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials

Albzea,

Almonayea,

Aljassar

et al. 2023

Medicina

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“…The results of in vitro dye spread assays indicate that the cells treated with MEL exhibited a significant enhancement in intercellular coupling. The upregulation of connexin mRNA and intercellular communication was observed to be facilitated by MT2R through a mechanism that is dependent on protein kinase C [ 18 , 19 ]. Melatonin exhibits anti-inflammatory properties that potentially contribute to its analgesic effects.…”

Section: Discussionmentioning

confidence: 99%

Impact of Melatonin as a Premedication Agent in Caesarean Section on Blood Loss and Postoperative Pain Level

Alkhfaji,

Kahloul,

Askar

et al. 2023

Anesthesiology Research and Practice

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Background. Postpartum hemorrhage (PPH) is a serious postdelivery condition with a high incidence of morbidity and mortality for women who undergo childbirth with or without a caesarean section. Melatonin has been suggested to increase the contractility of myometrium and reduce the pain score postoperatively, therefore it is believed that the use of melatonin before surgery may decrease blood loss, reduce pain score, and decrease the need for postoperative opioids. Objectives. The main objectives of this study are focused on the investigation of melatonin as a premedication agent to reduce blood loss and decrease pain score postoperatively in patients undergoing cesarean section under spinal anesthesia. Methods. 80 patients were scheduled for spinal anesthesia-based cesarean sections and randomly assigned to two groups, melatonin group (M) 40 patients and placebo group (P) 40 patients to receive either 10 mg of sublingual melatonin or a placebo of 90 minutes preoperatively. Hemoglobin levels were been measured preoperative and 12 hrs. Postoperatively, blood loss volume was calculated by measuring both the weight of used materials before and after the surgery and the volume sucked in the suction bottle after placental delivery. Postoperative visual pain score and analgesic requirements were used to evaluate pain levels. Results. Analyzed collected data showed a significant decrease in blood loss in the melatonin group in comparison with the placebo group as measured by the hemoglobin level. On the other hand, there is a significant decrease in pain score and analgesia requirement with the melatonin group compared to the placebo group. Conclusion. Melatonin is a promising premedication drug that has a significant impact on postpartum hemorrhage by reducing blood loss and pain levels of mothers who have undergone C-sections.

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Effect of melatonin in reducing blood loss during and after caesarean section

Cited by 2 publications

References 0 publications

Efficacy and Safety of Preoperative Melatonin for Women Undergoing Cesarean Section: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials

Efficacy and Safety of Preoperative Melatonin for Women Undergoing Cesarean Section: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials

Impact of Melatonin as a Premedication Agent in Caesarean Section on Blood Loss and Postoperative Pain Level

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