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To evaluate the effect of Mifepristone for the treatment of leiomyomata uteri. Materials and Methods: A total of 50 women who attended gynaecological outpatient department with various symptoms associated with leiomyoma uteri were taken up for the study. Routine blood investigations including complete blood count, renal function tests, liver function tests were done. Pelvic ultra sound and Endometrial sampling were performed. The women were administered 25 mg of Mifepristone daily starting from D1-D3 of menstrual cycle for a period of 3 months. The women were followed up at the end of 3 months and after 6 months for betterment of their symptoms, improvement in their haemoglobin status, alteration in their biochemical tests like LFT, RFT. Endometrial sampling was performed at the end of 3 months of treatment. Efficacy was estimated by the reduction in the volume of fibroids, size of uterus on follow up ultra sound scans at 3 and 6 months, and improvement in quality of life.Results: There was a significant decrease in size of uterus in 68% of women and the volume of fibroids decreased on an average to 54.8% following treatment. There was a reduction in the amount of menstrual flow in 84% of women. 22% of women reported hypomenorrhoea, 26% of women reported oligomenorrhoea, 8% reported amenorrhoea during the course of the treatment which was reversible after the completion of treatment. Almost all of them resumed regular menstruation by 6 months. Women also had significant improvement in quality of life as there was symptomatic relief and improvement of their haemoglobin levels. Conclusion: Mifepristone in the dosage of 25mg on a short course produced significant reduction in leiomyoma volume, uterine size and produced symptomatic improvement in women with fibroids.

Background: Chronic wounds are responsible for increase in burden to healthcare systems. The evidence concerning effectiveness of antibiotic therapy or optimal regimens is insufficient. Patients with chronic wounds receive significantly more systemic and topical antibiotics. Current guidelines for antibiotic prescribing for such wounds are often based on expert opinion rather than scientific fact. As there is increasing prevalence of antibiotic resistance, the relationships between antibiotic resistance and rationales for antibiotic therapy have to be determined. Current practice of antibiotic usage for chronic wounds and postoperative wounds in a tertiary care setting should be studied.Methods: Retrospective study was conducted from February 2017 to February 2018 using medical records of patients with wound admitted in surgical departments in HIMS, Hassan, Karnataka. The inpatient records were analysed, which includes duration of stay in the hospital, number of drugs/products per person, percentage of antibiotics prescribed, percentage of antibiotic injection prescribed, and other modalities used to treat wounds.Results: In present study, amongst 100 antimicrobial prescriptions, 26 females and 74 males. The most commonly prescribed parenteral antibiotic was ceftriaxone (58%), followed by metronidazole (56%). The average number of antibiotics per prescription was 2.8. The mean duration parenteral antibiotics given was 4.26 days during their hospital stay oral antibiotics were 5.18 days after the discharge from the hospital.Conclusions: The information generated shall be used to decide the policies to govern the prescription of antibiotics in the management of chronic wounds and post-operative wounds.

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