Effect of melatonin on the thymus, adrenal glands, and spleen in rats during acute stress

Ss, Pertsov

doi:10.1007/s10517-006-0153-9

Cited by 18 publications

(13 citation statements)

References 9 publications

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“…During aging, pineal peptides have geroprotective effect on thymus involution [79]. During acute stress, it prevents involution [80]. Melatonin strongly influences (elevates) the nocturnal thymic and serum level of thymosin alpha 1 and thymulin as well as the 24 hr rhythm of them [81,82].…”

Section: Effect Of Other (Non-thymic-self) Hormones On the Thymusmentioning

confidence: 99%

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The Immunoendocrine Thymus as a Pacemaker of Lifespan

Csaba¹

2016

Acta Microbiologica et Immunologica Hungarica

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The thymus develops from an endocrine area of the foregut, and retains the ancient potencies of this region. However, later it is populated by bone marrow originated lymphatic elements and forms a combined organ, which is a central part of the immune system as well as an influential element of the endocrine orchestra. Thymus produces self-hormones (thymulin, thymosin, thymopentin, and thymus humoral factor), which are participating in the regulation of immune cell transformation and selection, and also synthesizes hormones similar to that of the other endocrine glands such as melatonin, neuropeptides, and insulin, which are transported by the immune cells to the sites of requests (packed transport). Thymic (epithelial and immune) cells also have receptors for hormones which regulate them. This combined organ, which is continuously changing from birth to senescence seems to be a pacemaker of life. This function is basically regulated by the selection of self-responsive thymocytes as their complete destruction helps the development (up to puberty) and their gradual release in case of weakened control (after puberty) causes the erosion of cells and intercellular material, named aging. This means that during aging, self-destructive and non-protective immune activities are manifested under the guidance of the involuting thymus, causing the continuous irritation of cells and organs. Possibly the pineal body is the main regulator of the pacemaker, the neonatal removal of which results in atrophy of thymus and wasting disease and its later corrosion causes the insufficiency of thymus. The co-involution of pineal and thymus could determine the aging and the time of death without external intervention; however, external factors can negatively influence both of them.

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Section: Effect Of Other (Non-thymic-self) Hormones On the Thymusmentioning

confidence: 99%

“…Melatonin strongly influences (elevates) the nocturnal thymic and serum level of thymosin alpha 1 and thymulin as well as the 24 hr rhythm of them [81,82]. Under stress conditions, melatonin prevents thymus involution [80].…”

Section: Effect Of Other (Non-thymic-self) Hormones On the Thymusmentioning

confidence: 99%

The Immunoendocrine Thymus as a Pacemaker of Lifespan

Csaba¹

2016

Acta Microbiologica et Immunologica Hungarica

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“…Our previous experiments showed that intraperitoneal injection of melatonin under normal conditions is followed by an increase in the relative weight of the thymus, adrenal glands, and spleen in animals [3]. Exogenous melatonin had also a protective effect on stress-marker organs in rats during acute stress.…”

Section: Resultsmentioning

confidence: 92%

“…Our previous studies showed that melatonin produces a strong protective effect on the gastric mucosa [4] and prevents involution of the thymus and hypertrophy of the adrenal glands in rats under stress conditions [3]. It remains unclear whether the stress-protective effect of melatonin is associated with its direct influence on peripheral tissues or mediated by the hypothalamic SCN.…”

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confidence: 99%

Role of the hypothalamic suprachiasmatic nucleus in the effect of melatonin on the thymus, adrenal glands, and spleen in rats

Перцов

2006

Bull Exp Biol Med

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We studied the role of the hypothalamic suprachiasmatic nucleus in realization of the effect of melatonin on stress marker organs in rats under normal conditions and during acute stress. Stress induced involution of the thymus in active rats and adrenal gland hypertrophy in active and passive animals. Electrocoagulation of the suprachiasmatic nucleus induced a more pronounced decrease in the weight of the thymus and greater increase in the weight of the adrenal glands. Melatonin administration after electrocoagulation of the suprachiasmatic nucleus had no effect on the relative weight of the thymus, adrenal glands, and spleen in control and stressed animals. The influence of melatonin on the thymus, adrenal glands, and spleen is partly mediated by this structure of the brain.

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“…Além disso, o fotoperíodo, a pinealectomia e a melatonina exógena podem afetar o peso e as funções do timo e do baço em mamíferos e aves (Pertsov, 2006;Wronka et al, 2008).…”

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