Effect of memantine on C-reactive protein and lipid profiles in bipolar disorder

Chang, Hui Hua; Chen, Po See; Wang, Tzu Yun; Lee, Sheng Yu; Huang, San Yuan; Hong, Jau–Shyong; Yang, Yen Kuang; Lu, Ru Band

doi:10.1016/j.jad.2017.05.052

Cited by 3 publications

(6 citation statements)

References 52 publications

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“…CRP is a blood marker of inflammatory states. This molecule is synthetized by the liver in response to signal factors released by macrophages and fat cells, upon stimulation by the cytokines IL-1β, IL-6 and TNF-α during acute-phase inflammatory response, and elevate levels of this protein have been observed in BP patients [8]. For this reason, we believe to have found an important association between CRP and IR levels.…”

Section: Discussionmentioning

confidence: 69%

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Antidepressant Drugs Modulate Differentially Anti-inflammatory Lithium’s Property: An in Vitro and in Vivo Study

Barbisan¹,

Prado-Lima²,

Azzolin³

et al. 2018

JPP

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Li (lithium), a mood stabilizer has anti-inflammatory effect. However, in clinical practice, Li can be administered together with other antidepressants drugs, such as FLX (fluoxetine), IMI (imipramine), NOR (nortriptyline) and ESC (escitalopram). As interaction between Li and these antidepressant drugs on inflammatory modulation has not been investigated yet, we performed an in vitro protocol using a non-human macrophage cell line. Oxidative and inflammatory markers, as well as cell cycle analysis and cytokine gene expressions were compared among treatments. An IR (inflammatory ratio) was calculated based on the following oxidative-inflammatory variables: nitric oxide, superoxide anion, reactive oxygen molecules, cytokines IL-1β, IL-6, TNF-α and IL-10. The in vitro calculated IR data were validated through an in vivo analysis of 154 human subjects with similar IR. Li and control cells presented similar IR values. FLX, NOR and IMI increased slightly IR values indicating some proinflammatory effect, whereas ESC decreased IR values indicating some anti-inflammatory effect. However, cells exposed to Li + ESC triggered a proinflammatory response on macrophages. Thus, IR comparison results suggest that the Li anti-inflammatory effect is not universal and could be influenced by both basal macrophage-inflammatory state and interaction of other psychiatric drugs. These results could be useful to understand some inconsistencies observed in human studies involving Li and other psychiatric drugs.

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Section: Discussionmentioning

confidence: 69%

“…In fact, some psychiatric diseases, including bipolar disorder have been associated with chronic neuroinflammation status with increase of proinflammatory cytokines levels in blood peripheral circulation [8,9]. Li seems to present anti-inflammatory effect by inhibition of GSK-3…”

Section: David Publishingmentioning

confidence: 99%

Antidepressant Drugs Modulate Differentially Anti-inflammatory Lithium’s Property: An in Vitro and in Vivo Study

Barbisan¹,

Prado-Lima²,

Azzolin³

et al. 2018

JPP

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“…Furthermore, since immune dysfunction, such as elevated plasma CRP levels, has been strongly implicated in the pathophysiology of BD, targeting the immune system is a strategy for the treatment of bipolar disorder. 59 , 60 As such, numerous clinical trials have investigated the effects of anti-inflammatory agents in the treatment of BD. 60 - 62 Adjunctive anti-inflammatory agents have demonstrated antidepressant effects with N-acetylcysteine (NAC), pioglitazone, minocycline, and nonsteroidal anti-inflammatory drugs in the acute phase of bipolar depression.…”

Section: Discussionmentioning

confidence: 99%

“… 62 Moreover, regardless of illness phase, previous studies also suggested that anti-inflammatory agents are likely most beneficial in patients with mood disorder when subgrouped by immune dysregulation or by childhood maltreatment. 59 , 71 Since low-dose memantine serves as an anti-inflammatory agent through the BDNF signaling pathway, 74 , 75 BD patients with high initial plasma CRP levels receiving memantine adjunct treatment have a reduced risk of inflammation and metabolic imbalance. 59 Additionally, a report showed that the plasma CRP level could predict the differential responses to antidepressants, 76 and clinical trials of tumor necrosis factor antagonists and omega-3 fatty acids demonstrated the role of the initial plasma CRP level in predicting individual treatment responses in patients with major depressive disorder.…”

Section: Discussionmentioning

confidence: 99%

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Roles of C-reactive protein polymorphisms and life event changes on cognitive function in bipolar patients receiving valproate

Chen

Tang

Chang

2022

Int J Immunopathol Pharmacol

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Introduction Patients with bipolar disorder (BD) exhibit an inflamed condition that is associated with metabolic disturbance and cognitive impairment. Whether inflammation, represented by C-reactive protein (CRP), is causally associated with BD and influences treatment outcome has not been established. Methods We examined whether CRP is a causal factor for the risk of BD in drug-naïve, depressed BD patients and investigated whether polymorphisms in CRP and life event changes influence cognitive function in BD patients receiving valproate (VPA) treatment. Results Our results showed that BD patients had significantly higher CRP levels and worse cognitive function than the controls, while the frequencies of CRP single nucleotide polymorphisms in BD patients and in controls were not different. In addition, the life event scale score was higher for BD patients than for controls. Furthermore, the genotypes of CRP polymorphisms and the interactions between polymorphisms of CRP and life event scale score had a significant influence on cognitive performance in BD patients after 12 weeks of VPA treatment. Conclusion Our study demonstrated the clinical utility of the application of functional genetics in clarifying the interactions among CRP, life event stress, and BD and suggested the important roles of CRP gene–environment interactions in developing treatment strategies for BD.

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Impact of NMDA receptors block versus GABA-A receptors modulation on synaptic plasticity and brain electrical activity in metabolic syndrome

Amin,

Shaltout,

El Gazzar

et al. 2024

Advances in Medical Sciences

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Effect of memantine on C-reactive protein and lipid profiles in bipolar disorder

Abstract: BD patients with high initial CRP levels receiving memantine adjunct treatment have a reduced risk of inflammation and metabolic imbalance. Prospective studies are needed to confirm the long-term outcome for memantine adjunct therapy in BD patients.

Cited by 3 publications

References 52 publications

Antidepressant Drugs Modulate Differentially Anti-inflammatory Lithium’s Property: An in Vitro and in Vivo Study

Antidepressant Drugs Modulate Differentially Anti-inflammatory Lithium’s Property: An in Vitro and in Vivo Study

Roles of C-reactive protein polymorphisms and life event changes on cognitive function in bipolar patients receiving valproate

Impact of NMDA receptors block versus GABA-A receptors modulation on synaptic plasticity and brain electrical activity in metabolic syndrome

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