Effect of menstrual cycle phase on corticolimbic brain activation by visual food cues

Frank, Tamar C.; Kim, Ginah L.; Krzemien, Alicja A.; Vugt, Dean A. Van

doi:10.1016/j.brainres.2010.09.071

Cited by 99 publications

(66 citation statements)

References 68 publications

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“…Frank et al (232) reported that the differential effect of pictures of high energy-density foods vs. nonfoods was larger in the follicular phase than in the luteal phase in the NAc, amygdala, and hippocampus; the effect of low energy-density foods vs. nonfoods was significant only in the hippocampus. Alonso-Alonso et al (4) tested the effects of pictures of food before and after a standard meal designed to contain 20% of their daily energy need; this was done once early (days 3-6 after the onset of menstruation) and once late (days 10 -13) in the follicular phase of the menstrual cycle.…”

Section: R1243 Sex Differences In the Physiology Of Eatingmentioning

confidence: 99%

Sex differences in the physiology of eating

Asarian

Geary²

2013

American Journal of Physiology-Regulatory, Integrative and Comp

414

349

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(HPG) axis function fundamentally affects the physiology of eating. We review sex differences in the physiological and pathophysiological controls of amounts eaten in rats, mice, monkeys, and humans. These controls result from interactions among genetic effects, organizational effects of reproductive hormones (i.e., permanent early developmental effects), and activational effects of these hormones (i.e., effects dependent on hormone levels). Male-female sex differences in the physiology of eating involve both organizational and activational effects of androgens and estrogens. An activational effect of estrogens decreases eating 1) during the periovulatory period of the ovarian cycle in rats, mice, monkeys, and women and 2) tonically between puberty and reproductive senescence or ovariectomy in rats and monkeys, sometimes in mice, and possibly in women. Estrogens acting on estrogen receptor-␣ (ER␣) in the caudal medial nucleus of the solitary tract appear to mediate these effects in rats. Androgens, prolactin, and other reproductive hormones also affect eating in rats. Sex differences in eating are mediated by alterations in orosensory capacity and hedonics, gastric mechanoreception, ghrelin, CCK, glucagon-like peptide-1 (GLP-1), glucagon, insulin, amylin, apolipoprotein A-IV, fatty-acid oxidation, and leptin. The control of eating by central neurochemical signaling via serotonin, MSH, neuropeptide Y, Agouti-related peptide (AgRP), melanin-concentrating hormone, and dopamine is modulated by HPG function. Finally, sex differences in the physiology of eating may contribute to human obesity, anorexia nervosa, and binge eating. The variety and physiological importance of what has been learned so far warrant intensifying basic, translational, and clinical research on sex differences in eating.neuroendocrinology; estrogens; testosterone; eating disorders; obesity SEX DIFFERENCES ARE PERVASIVE in physiology and medicine (51,64,73,109,110,466,797,826). The controls of eating and energy homeostasis are no exceptions. It was observed approximately 100 years ago that removal of the ovaries leads to marked accretion of adipose tissue in rats (697), that daily food intake expressed as kilocalories per gram body weight differs between male and female rats (778), and that food intake varies regularly through the ovarian cycle in intact female rats (674, 779). Sex differences in eating have been the subject of physiological research ever since. The clinical relevance of this work is increasingly evident. In the United States, women are approximately threefold more vulnerable than men to psychiatric eating disorders (346,351) and approximately twofold more vulnerable to severe and morbid obesity (BMI Ն 35 and 40 kg/m 2 , respectively, mass/height 2 ) (226). Women also appear to suffer more from these disorders in terms of physical and psychological functioning and quality of life (24,84,273,292,465,531,762). The increased obesity burden suffered by women is reflected in the fact that Ͼ80% of bariatric surgery patients in the U...

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Section: R1243 Sex Differences In the Physiology Of Eatingmentioning

confidence: 99%

Sex differences in the physiology of eating

Asarian

Geary²

2013

American Journal of Physiology-Regulatory, Integrative and Comp

414

349

View full text Add to dashboard Cite

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“…No Fasted-Ghrelin visit was performed because endogenous ghrelin concentrations are high when fasted. Women were always scanned in days 1-14 of their menstrual cycle to attenuate variations in reward responses including food over the menstrual cycle (28).…”

Section: Study Protocolmentioning

confidence: 99%

Ghrelin mimics fasting to enhance human hedonic, orbitofrontal cortex, and hippocampal responses to food

Goldstone¹,

Prechtl²,

Scholtz³

et al. 2014

The American Journal of Clinical Nutrition

125

134

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Ghrelin administration and fasting have similar acute stimulatory effects on hedonic responses and the activation of corticolimbic reward-cognitive systems during food evaluations. Similar effects of recurrent or chronic hyperghrelinemia on an anticipatory food reward may contribute to the negative impact of skipping breakfast on dietary habits and body weight and the long-term failure of energy restriction for weight loss.

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“…Female participants were recruited following evidence that young women are more responsive to food-related cues, both in terms of eating (Anschutz et al, 2011) and brain activation (Frank et al, 2010b). All participants were taking the monophasic combined oral contraceptive pill, controlling for known hormonal effects on reward sensitivity and visual responses to food cues (Frank et al, 2010a). Participants gave written informed consent and were paid £22 ($35) for participating.…”

Section: Participantsmentioning

confidence: 99%