Effect of metformin on the growth hormone response to growth hormone–releasing hormone in obese women with polycystic ovary syndrome

Guido, Maurizio; Romualdi, Daniela; Giuliani, Maddalena; Suriano, Rosanna; Tienforti, Daniele; Costantini, Barbara; Lanzone, Antonio

doi:10.1016/j.fertnstert.2005.05.027

Cited by 10 publications

(2 citation statements)

References 36 publications

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“…When using ovulation induction treatment, GH's application can improve ovarian responsiveness to GnRH. PCOS patients often present low basal GH; after applying levodopa, GH rising magnitude is reduced, which shows that PCOS patients have not only growth hormone deficiency, but also low activity of hypothalamic dopamine [64, 65]. …”

Section: Resultsmentioning

confidence: 99%

A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility

Liu

Zeng

Yang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Aim. To explore the pharmacological mechanism of Xiaoyao powder (XYP) on anovulatory infertility by a network pharmacology approach. Method. Collect XYP's active compounds by traditional Chinese medicine (TCM) databases, and input them into PharmMapper to get their targets. Then note these targets by Kyoto Encyclopedia of Genes and Genomes (KEGG) and filter out targets that can be noted by human signal pathway. Get the information of modern pharmacology of active compounds and recipe's traditional effects through databases. Acquire infertility targets by Therapeutic Target Database (TTD). Collect the interactions of all the targets and other human proteins via String and INACT. Put all the targets into the Database for Annotation, Visualization, and Integrated Discovery (DAVID) to do GO enrichment analysis. Finally, draw the network by Cytoscape by the information above. Result. Six network pictures and two GO enrichment analysis pictures are visualized. Conclusion. According to this network pharmacology approach some signal pathways of XYP acting on infertility are found for the first time. Some biological processes can also be identified as XYP's effects on anovulatory infertility. We believe that evaluating the efficacy of TCM recipes and uncovering the pharmacological mechanism on a systematic level will be a significant method for future studies.

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Section: Resultsmentioning

confidence: 99%

A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility

Liu

Zeng

Yang

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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“…At present, clinical data do not evidence a prevailing inhibitory action of metformin on GH-secreting pituitary cells in vivo. Actually, the complexity related to the pathological conditions which may per se cause alterations of somatotroph function, to the pleiotropic effects of metformin in different tissues and to the duration of treatments, make it difficult to draw final conclusions about a possible direct effect of metformin on pituitary cells in vivo (75,76). The data obtained by using in vitro cultured pituitary cells suggest that the targets of metformin in vivo include the anterior pituitary and, in detail, also the GH-secreting cells.…”

Section: Somatotroph Cell Functionmentioning

confidence: 99%

How treatments with endocrine and metabolic drugs influence pituitary cell function

Tulipano

2020

Endocrine Connections

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A variety of endocrine and metabolic signals regulate pituitary cell function acting through the hypothalamus-pituitary neuroendocrine axes or directly at the pituitary level. The underlying intracellular transduction mechanisms in pituitary cells are still debated. AMP-activated protein kinase (AMPK) functions as a cellular sensor of low energy stores in all mammalian cells and promotes adaptive changes in response to calorie restriction. It is also regarded as a target for therapy of proliferative disorders. Various hormones and drugs can promote tissue-specific activation or inhibition of AMPK by enhancing or inhibiting AMPK phosphorylation, respectively. This review explores the preclinical studies published in the last decade that investigate the role of AMP-activated protein kinase in the intracellular transduction pathways downstream of endocrine and metabolic signals or drugs affecting pituitary cell function, and its role as a target for drug therapy of pituitary proliferative disorders. The effects of the hypoglycemic agent metformin, which is an indirect AMPK activator, are discussed. The multiple effects of metformin on cell metabolism and cell signalling and ultimately on cell function may be either dependent or independent of AMPK. The in vitro effects of metformin may also help highlighting differences in metabolic requirements between pituitary adenomatous cells and normal cells.

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Effects of ghrelin administration on endocrine and metabolic parameters in obese women with polycystic ovary syndrome

Fusco

Bianchi

Mancini

et al. 2007

J Endocrinol Invest

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Effect of metformin on the growth hormone response to growth hormone–releasing hormone in obese women with polycystic ovary syndrome

Cited by 10 publications

References 36 publications

A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility

A Network Pharmacology Approach to Explore the Pharmacological Mechanism of Xiaoyao Powder on Anovulatory Infertility

How treatments with endocrine and metabolic drugs influence pituitary cell function

Effects of ghrelin administration on endocrine and metabolic parameters in obese women with polycystic ovary syndrome

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