Effect of Microneedle Type on Transdermal Permeation of Rizatriptan

Uppuluri, Chandra Teja; Shaik, Ashraf Sultana; Han, Tao; Nayak, Atul; Nair, Karthik J.; Whiteside, Ben; Nalluri, Buchi N.; Das, Diganta Bhusan

doi:10.1208/s12249-016-0702-0

Cited by 25 publications

(21 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Good correlations were observed between the dimensionless concentrations determined theoretically as well as experimentally [101].…”

Section: Simulation Of Solid Mnsmentioning

confidence: 53%

“…Skin viscoelasticity determines the amount of force required by MN patch to penetrate the skin [90]. To obtain effective improvement of skin permeability, effects of different MN tip radius, length, and number in an array have been modelled in previous studies [95][96][97][98][99][100][101][102]. Other researchers have focused on modelling the specific MN application method [103,104].…”

Section: Parameters For Mn Modellingmentioning

confidence: 99%

“…K is related to the diffusion coefficient (D) as discussed by Al-Qallaf and Das [111]. Uppuluri et al [101] analysed the implications of different MN geometries (e.g., length, number of MNs and shape) on the TDD of rizatriptan drug molecules. A scaling analysis was carried out using the Buckingham π theorem, which defined the interplay among different dimensionless parameters of drug concentration and MN geometry as shown in Equation (19) [87].…”

Section: Simulation Of Solid Mnsmentioning

confidence: 99%

“…Equations (29) and (30) show the relation between dimensionless insulin concentration and different length of MNs. This analysis was based on the research results of Uppuluri et al [101], which were discussed earlier. The correlations indicated that the effect of the change in MN length on the effective insulin delivery can be easily explained by optimal scaling analysis.…”

Section: Simulation Of Dissolving Mnsmentioning

confidence: 99%

See 3 more Smart Citations

Mathematical Modelling, Simulation and Optimisation of Microneedles for Transdermal Drug Delivery: Trends and Progress

et al. 2020

Self Cite

View full text Add to dashboard Cite

In the last two decades, microneedles (MNs) have received significant interest due to their potential for painless transdermal drug delivery (TDD) and minimal skin damage. MNs have found applications in a range of research and development areas in drug delivery. They have been prepared using a variety of materials and fabrication techniques resulting in MN arrays with different dimensions, shapes, and geometries for delivery of a variety of drug molecules. These parameters play crucial roles in determining the drug release profiles from the MNs. Developing mathematical modelling, simulation, and optimisation techniques is vital to achieving the desired MN performances. These will then be helpful for pharmaceutical and biotechnological industries as well as professionals working in the field of regulatory affairs focusing on MN based TDD systems. This is because modelling has a great potential to reduce the financial and time cost of both the MNs’ studies and manufacturing. For example, a number of robust mathematical models for predicting the performance of the MNs in vivo have emerged recently which incorporate the roles of the structural and mechanical properties of the skin. In addressing these points, this review paper aims to highlight the current status of the MN modelling research, in particular, the modelling, simulation and optimisation of the systems for drug delivery. The theoretical basis for the simulation of MN enhanced diffusion is discussed within this paper. Thus, this review paper provides a better understanding of the modelling of the MN mediated drug delivery process.

show abstract

“…Good correlations were observed between the dimensionless concentrations determined theoretically as well as experimentally [101].…”

Section: Simulation Of Solid Mnsmentioning

confidence: 53%

Section: Parameters For Mn Modellingmentioning

confidence: 99%

Section: Simulation Of Solid Mnsmentioning

confidence: 99%

Section: Simulation Of Dissolving Mnsmentioning

confidence: 99%

See 2 more Smart Citations

Mathematical Modelling, Simulation and Optimisation of Microneedles for Transdermal Drug Delivery: Trends and Progress

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Some of the structures that include 1,2,4-triazole have already found applications in medicine and agricultural chemistry. In this way, anastrozole is used as cancer treatment, and in particular, as breast cancer medication [1]; fluconazole is an antifungal drug [2]; rizatriptan is used to mitigate migraine and headache [3]; myclobutanil is a fungicide that has low carcinogenicity [4]. However, these compounds have one common feature: they do not contain a 1,2,4-triazole ring as a central system but feature it as a side substituent of the main structure.…”

Section: Introductionmentioning

confidence: 99%

Вплив Замісників Різної Природи У 3- Та 5-Му Положеннях 4н-1,2,4-Триазолу На Поведінку Похідних В Умовах Гх-Мс-Аналізу

Yaroshenko¹,

Panasenko

Pruhlo

2020

J. of Chem. and Tech.

View full text Add to dashboard Cite

Pharmaceutical products require appropriate quality control, which comprises a set of tests aimed at the determination of assays of the substances. Chromatographic methods are one of the most abundant analytical methods applied in routine analyses of pharmaceuticals. Information on the behavior of the compounds under certain analytical conditions is valuable in the process of analytical method development. This work was aimed at revealing the impact of substituents of various natures at two positions of triazole ring on the behavior of new 3-thio-1,2,4-triazoles under GC-MS conditions and evaluating the applicability of GC-MS method for the analysis of these compounds. Gas chromatography was used in combination with mass spectrometry. New 1,2,4-triazole derivatives were obtained at the Department of Natural Sciences for International Students and Toxicological Chemistry of Zaporizhzhia State Medical University. For the experiment, two groups of compounds were formed, each having different substituents at C-3 and C-5 of triazole molecule, respectively. The analysis was held using Agilent 7890B GC system coupled with Agilent 5977B mass selective detector. Compounds were separated on a non-polar column. The following parameters were assessed and compared for identification and study of chromatographic behavior of the compounds: mass spectra, retention times, symmetry factors, and relative responses (against reference compound). It was shown that there is no direct relation between melting point and retention time; instead, the nature of substituents significantly affects the chromatographic behavior. The strongest response belongs to compounds that have phenyl moiety at C-5 and alkyl substituent attached through thiol group at C-3 of the triazole ring. Thiophen-2-yl and methyl at C-5, as well as acetate and ester groups attached through thiol group at C-3 of the cycle, decrease chromatographic response. GC-MS can be applied for the analysis of biologically active 1,2,4-triazoles, though with several limitations. The higher the polarity of the compound, the worse the response and peak shape; these circumstances complicate GC-MS analysis of 1,2,4-triazole derivatives. Apart from providing information on physicochemical properties of the compounds, the obtained experimental data provide some valuable insights into permeability of the new triazole derivatives through biological membranes, which could be useful in drug design.

show abstract

Construction of a core-shell microneedle system to achieve targeted co-delivery of checkpoint inhibitors for melanoma immunotherapy

et al. 2020

View full text Add to dashboard Cite

Effect of Microneedle Type on Transdermal Permeation of Rizatriptan

Cited by 25 publications

References 18 publications

Mathematical Modelling, Simulation and Optimisation of Microneedles for Transdermal Drug Delivery: Trends and Progress

Mathematical Modelling, Simulation and Optimisation of Microneedles for Transdermal Drug Delivery: Trends and Progress

Вплив Замісників Різної Природи У 3- Та 5-Му Положеннях 4н-1,2,4-Триазолу На Поведінку Похідних В Умовах Гх-Мс-Аналізу

Construction of a core-shell microneedle system to achieve targeted co-delivery of checkpoint inhibitors for melanoma immunotherapy

Contact Info

Product

Resources

About