Effect of micronized cellulose powder on the efficacy of topical oxymetazoline in allergic rhinitis

Valerieva, Anna; Popov, Todor A.; Staevska, Maria; Kralimarkova, Tanya; Petkova, Eva; E, Valerieva; Mustakov, Tihomir B.; Lazarova, Tsvetelina; Dimitrov, Vasil; Mk, Church

doi:10.2500/aap.2015.36.3879

Cited by 15 publications

(15 citation statements)

References 24 publications

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“…However, several previous studies have evaluated the efficacy of NCP in patients who have stopped the use of intranasal steroids or have never used them before and during the enrollment,8911 which is similar to our study. A recent study has demonstrated the efficacy of NCP in enhancing oxymetazoline-increased PNIF in adults with moderate to severe persistent perineal AR 24. A real-life study on the effects of NCP as an add-on to intranasal as-needed treatment, in subjects with pollen AR has demonstrated a decrease in combined symptom and medication scores (CSMS) in patients receiving NCP when compared to those receiving placebos 25.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Nasal Cellulose Powder in the Symptomatic Treatment of Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Trial

Manuyakorn

Klangkalya

Kamchaisatian

et al. 2017

Allergy Asthma Immunol Res

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PurposeNasal Cellulose Powder (NCP), which can prevent from binding an allergen to nasal mucosa, may reduce allergic rhinitis (AR) symptoms in dust mite-sensitized children. This study was conducted to assess the efficacy of NCP in improving clinical symptoms of a nasal airflow limitation and the response of nasal inflammatory cells.MethodsChildren with dust mite-sensitized AR aged 6-18 years were recruited. After a 4-week run-in period, NCP or a placebo was administered, 1 puff per nostril 3 times daily for 4 weeks. The nasal provocation test (NPT) with Dermatophagoides pteronyssinus (Der p) was performed before and after treatment. The daily symptom scores (DSS), daily medication scores (DMS), the peak nasal inspiratory flows (PNIF), nasal airway resistance (NAR), as well as the maximum tolerated dose of NPT and eosinophil counts in nasal scraping, were evaluated.ResultsSixty children (30 NCP and 30 placebos) were enrolled. Before treatment, there were no significant differences in age, dust mite control measures, DSS, DMS, PNIF, NAR, the maximum tolerated dose of NPT, or nasal eosinophil scores between children receiving NCP and placebos. After treatment, there were no significant differences between the NCP and placebo groups in the median (range) of the outcomes—DSS: 2.06 (0.18-3.77) vs 1.79 (0.08-7.79), P=0.756; DMS: 1.60 (0-5.13) vs 0.56 (0-4.84), P=0.239; PNIF (L/min): 110 (60-160) vs 100 (50-180), P=0.870; NAR (Pa/cm3/s): 0.40 (0.20-0.97) vs 0.39 (0.24-1.32), P=0.690; the maximum tolerated dose of NPT and the nasal eosinophil scores: 1 (0-4) vs 1 (0-4), P=0.861.ConclusionsNCP treatment may not be more effective than placebo treatment in dust mite-sensitized AR children.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Nasal Cellulose Powder in the Symptomatic Treatment of Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Trial

Manuyakorn

Klangkalya

Kamchaisatian

et al. 2017

Allergy Asthma Immunol Res

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“…In another interesting clinical trial, hydroxypropylmethylcellulose (HPMC) was tested in the treatment of allergic rhinitis [ 137 ]. It has been hypothesized that inhaled allergens, as well as other substances, can disrupt the integrity of nasal mucosal lining thus favoring the contact of the body with external harmful agents.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…To down regulate inflammation and mucosal congestion, decongestant substances such as oxymetazoline nasal spray, 0.05% are often used. Recently, HPMC has been employed in addition to oxymetazoline [ 137 ] due to its known mucoprotective effects based on its viscoelastic properties. Forty allergic rhinitis patients were divided into two groups: the first was locally treated by oxymetazoline, followed by HPMC, the second was treated similarly but instead of HPMC, lactose powder (placebo) was administered.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Potential Applications of Nanocellulose-Containing Materials in the Biomedical Field

et al. 2017

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Because of its high biocompatibility, bio-degradability, low-cost and easy availability, cellulose finds application in disparate areas of research. Here we focus our attention on the most recent and attractive potential applications of cellulose in the biomedical field. We first describe the chemical/structural composition of cellulose fibers, the cellulose sources/features and cellulose chemical modifications employed to improve its properties. We then move to the description of cellulose potential applications in biomedicine. In this field, cellulose is most considered in recent research in the form of nano-sized particle, i.e., nanofiber cellulose (NFC) or cellulose nanocrystal (CNC). NFC is obtained from cellulose via chemical and mechanical methods. CNC can be obtained from macroscopic or microscopic forms of cellulose following strong acid hydrolysis. NFC and CNC are used for several reasons including the mechanical properties, the extended surface area and the low toxicity. Here we present some potential applications of nano-sized cellulose in the fields of wound healing, bone-cartilage regeneration, dental application and different human diseases including cancer. To witness the close proximity of nano-sized cellulose to the practical biomedical use, examples of recent clinical trials are also reported. Altogether, the described examples strongly support the enormous application potential of nano-sized cellulose in the biomedical field.

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“…Indeed, the extensive clinical experience gathered so far does not suggest deleterious effects of CP: no signs of impaired mucosa or of plugging of the ostia of the paranasal sinuses have been detected after months of usage. The formulation even appears to have some “healing” effect on its own [6]. What we have documented in a real-life randomized double-blind study in subjects with seasonal allergic rhinitis is a moderate slowdown of the nasal mucociliary clearance as assessed by saccharine test after 1 month of regular application [7].…”

mentioning

confidence: 99%

Powder Cellulose in Allergic Rhinitis Management: Relevance of in vitro Findings to Real-Life Safety

Popov

Emberlin

Church

et al. 2019

Int Arch Allergy Immunol

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Effect of micronized cellulose powder on the efficacy of topical oxymetazoline in allergic rhinitis

Abstract: clinicaltrials.gov identifier: NCT01986582.

Cited by 15 publications

References 24 publications

Efficacy of Nasal Cellulose Powder in the Symptomatic Treatment of Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Trial

Efficacy of Nasal Cellulose Powder in the Symptomatic Treatment of Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled Trial

Potential Applications of Nanocellulose-Containing Materials in the Biomedical Field

Powder Cellulose in Allergic Rhinitis Management: Relevance of in vitro Findings to Real-Life Safety

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