Effect of midazolam premedication on the dose of propofol for laryngeal mask airway insertion in children

Bhaskar, Priyesh; Malik, Amrita; Kapoor, Rajni; Kohli, Monica; Agarwal, Jyotsana; Harjai, Mamta

doi:10.4103/0970-9185.74595

Cited by 9 publications

(1 citation statement)

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“…This short-acting drug is associated with water-soluble properties, rapid and painless effect, or thrombophlebitis at the time of injection and is associated with low hemodynamic changes. [ 16 ] In addition to sedative effects, this drug has beneficial effects such as futuristic forgetfulness, minimal weakening of ventilation and circulatory system, anticonvulsants, rare physical dependence and allergic reactions, and having a selective antagonist (flumazenil). [ 17 18 ] Numerous studies have shown that midazolam compared to thiopental in people with underlying disease has better hemodynamic stability.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of the Effect of Anesthesia Induction with the Use of Four Drug Combinations Including “Propofol,” “Etomidate-Propofol,” “Thiopental,” and “Midazolam-Thiopental” on Hemodynamic Changes during the Insertion of Laryngeal Mask in Eye Surgery

Shetabi¹,

Montazeri²,

Ghoodjani³

2022

Advanced Biomedical Research

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Background: This study aimed to compare the efficacies of four anesthetic induction drugs (thiopental, propofol, midazolam-thiopental, and etomidate-propofol) on cardiovascular response during laryngeal mask airway (LMA) placement in eye surgery. Materials and Methods: The present clinical trial study included 128 patients who were candidates for ophthalmic surgery in four groups. Patients in the first group were given a combination of midazolam (0.04 mg/kg) with thiopental (2.5 mg/kg) (Group T + M). We administered propofol alone (2.5 mg/kg) to patients in the second group (Group P). The third group received a combination of etomidate (0.1 mg/kg) with propofol (1 mg/kg) (ET + P group) and patients in the fourth group received thiopental drug (5 mg/kg) alone (Group T). Then, the stability of patients' hemodynamic parameters before anesthesia was evaluated and compared immediately after anesthesia, 1, 3, and 5 min after LMA placement. Results: There was no significant difference between the four groups in changes in oxygen saturation level (P > 0.05). Furthermore, the difference between decreased systolic blood pressure and diastolic blood pressure over time was not significant in 5 min in both Groups T + M and T (P > 0.05). In addition, the stability of these two groups was higher than the other two groups (P < 0.05) and the most unstable group was Group P. The changes pulse ratein the P group were significant (P < 0.05). Conclusion: According to the results of the current study, thiopental and Midazolam can be used as an effective induction compound to facilitate LMA insertion with higher hemodynamic stability compared to propofol alone, propofol and etomidate, and thiopental alone.

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Section: Introductionmentioning

confidence: 99%