Effect of moderate exercise on peritoneal neutrophils from juvenile rats

Ferreira, Diorginis José Soares; Pedroza, Anderson Apolonio; Silva, Aline Isabel da; Sousa, Shirley Maria de; Pithon-Curi, Tânia Cristina; Lagranha, Cláudia Jacques

doi:10.1139/apnm-2015-0056

Cited by 5 publications

(3 citation statements)

References 14 publications

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“…In terms of activity and function, physical exercise typically induces an initial activation of neutrophils. This is demonstrated through the release of enzymes (172, 173) and subsequent changes in crucial effector functions, including phagocytosis and respiratory burst activity (174,175). Acute exercise has been shown to attenuate neutrophil apoptosis, possibly by its action on the inducible nitric oxide synthase (iNOS)nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)myeloid cell leukemia 1 (Mcl-1) pathway (176), as well as calcium and redox signaling (177).…”

Section: Neutrophilsmentioning

confidence: 99%

Mechanisms underlying the beneficial effects of physical exercise on multiple sclerosis: focus on immune cells

Zong,

Yu,

Zhang

et al. 2023

Front. Immunol.

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Multiple sclerosis (MS) is a prevalent neuroimmunological illness that leads to neurological disability in young adults. Although the etiology of MS is heterogeneous, it is well established that aberrant activity of adaptive and innate immune cells plays a crucial role in its pathogenesis. Several immune cell abnormalities have been described in MS and its animal models, including T lymphocytes, B lymphocytes, dendritic cells, neutrophils, microglia/macrophages, and astrocytes, among others. Physical exercise offers a valuable alternative or adjunctive disease-modifying therapy for MS. A growing body of evidence indicates that exercise may reduce the autoimmune responses triggered by immune cells in MS. This is partially accomplished by restricting the infiltration of peripheral immune cells into the central nervous system (CNS) parenchyma, curbing hyperactivation of immune cells, and facilitating a transition in the balance of immune cells from a pro-inflammatory to an anti-inflammatory state. This review provides a succinct overview of the correlation between physical exercise, immune cells, and MS pathology, and highlights the potential benefits of exercise as a strategy for the prevention and treatment of MS.

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Section: Neutrophilsmentioning

confidence: 99%

Mechanisms underlying the beneficial effects of physical exercise on multiple sclerosis: focus on immune cells

Zong,

Yu,

Zhang

et al. 2023

Front. Immunol.

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“…Physical exercise was used for rodents (running on a motorized treadmill; INSIGHT, model EP-131). Each familiarization session included placing the rats on the treadmill switched off for 10 min and then turning on the treadmill at 8 m/min for 5 min [13]. Moderate-intensity exercise was performed in sessions of 40 min a day, three times a week, for eight weeks (from PND31 to 87), according to the following protocol [14]: 5 min warming up at a speed of 12 ± 2 m/min, 30 min at a main speed of 20 ± 2 m/min, and 5 min cooling down at a speed of 12 ± 2 m/min.…”

Section: Exercise Programmentioning

confidence: 99%

Treadmill Exercise Reverses the Adverse Effects of Intermittent Fasting on Behavior and Cortical Spreading Depression in Young Rats

Braz,

Figueira de Oliveira,

Costa

et al. 2023

Brain Sciences

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Intermittent fasting (IF) and physical exercise (PE) have beneficial psychological and physiological effects, improving memory and anxiety-like behavior. However, the impact of this combination on brain electrophysiological patterns is unknown. We aimed to evaluate the behavior and parameters of a brain excitability-related phenomenon named cortical spreading depression (CSD) in young rats (31–87 days of life) submitted to IF and treadmill PE for eight weeks. Sixty-four male and female Wistar rats aged 24 days were randomized into control, IF, PE, and IF+PE groups. Behavioral tests (open field (OF), object recognition, and elevated plus maze (EPM)) were performed, and the CSD propagation features were recorded. IF caused behavioral responses indicative of anxiety (lower number of entries and time spent in the OF center and EPM open arms). IF also reduced the discrimination index for object recognition memory tests and increased the propagation velocity of CSD. PE rats displayed more entries into the OF center and lowered CSD propagation speed. Data suggest that IF worsens anxiety-like behavior and memory and accelerates CSD in young rats. In contrast, PE reverted the unfavorable effects of IF. The brain effects of IF and PE at younger ages are recommended for study.

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“…type of exercise, intensity, volume, and periodization) and their different effects throughout the organism still limit the exercise-induced hormesis understanding 38 . Thereby, our laboratory has investigated the benefits of exercise in tissue-dependent oxidative stress [39][40][41][42] , and recently, we demonstrated that daily moderate physical exercise applied at juvenile ages, can decrease the risk of developing CVD by improving cardiac mitochondrial function and oxidative stress resilience in male rats 43 .…”

Section: Introductionmentioning

confidence: 99%

Fish oil supplementation and physical exercise during the development period increase cardiac antioxidant capacity in Wistar rats

Melo,

Macêdo,

Costa

et al. 2022

Motriz: rev. educ. fis.

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To investigate if treadmill exercise (Ex) associated with fish oil (FO) supplementation during lactation would influence the biochemical profile as well as the oxidative balance in the hearts of male juvenile rats. Methods: Fifteen days-old rats were submitted to a daily moderate Ex training (based on their maximal running capacity) and FO supplementation for 4 weeks. Forty-eight hours after the last exercise session, blood fasting glucose and lipid profile were assessed according to the manufacturer's recommendations, while the oxidative status of the hearts was evaluated via colorimetric and absorbance-based assays. Results: FO associated with Ex decreased triglycerides (TG-79.27 ± 5.75 to 60.24 ± 6.25 mg/dL) and very-low-density lipoprotein cholesterol levels (VLDL-15.85 ± 1.15 to 12.05 ± 1.25 mg/dL) when compared to sedentary animals. FO, alone, reduced atherogenic index (AI-1.14 ± 0.03 vs. 1.01 ± 0.04 a.u) while increased high-density lipoprotein cholesterol (HDL-43.90 ± 2.50 vs. 59.43 ± 3.15 mg/dL) of sedentary animals. Additionally, both Ex (67.3 ± 13.5 nmol/mg prot) and FO supplementation (56.6 ± 5.5 nmol/mg prot) decreased the oxidative damage to lipids in non-trained animals (105.8 ± 10.8 nmol/mg prot). The interventions also protected the protein content from oxidative stress (Ex-5.15 ± 0.46; FO-4.5 ± 0.5; and vehicle sedentary-7.3 ± 0.6 µmol/mg prot), while increasing the antioxidant defense and oxidative metabolism. Conclusion: Our findings suggest that intervention in juvenile rats can improve cardiac metabolism. These are the first findings to show the positive effects of the association between FO and moderate treadmill Ex during the critical period of development. We believe these results can drive early-life origins of heart disease through different avenues and, possibly, assist the development of a heart disease prevention program as well as an adjunctive therapeutic resource.

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Effect of moderate exercise on peritoneal neutrophils from juvenile rats

Cited by 5 publications

References 14 publications

Mechanisms underlying the beneficial effects of physical exercise on multiple sclerosis: focus on immune cells

Mechanisms underlying the beneficial effects of physical exercise on multiple sclerosis: focus on immune cells

Treadmill Exercise Reverses the Adverse Effects of Intermittent Fasting on Behavior and Cortical Spreading Depression in Young Rats

Fish oil supplementation and physical exercise during the development period increase cardiac antioxidant capacity in Wistar rats

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