Effect of molecular weight and concentration of legume condensed tannins on in vitro larval migration inhibition of Haemonchus contortus

Naumann, H. D.; Armstrong, S. A.; Lambert, B.D.; Muir, James P.; Tedeschi, L. O.; Kothmann, M.M.

doi:10.1016/j.vetpar.2013.09.025

Cited by 25 publications

(22 citation statements)

References 36 publications

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“…However, there may be other metabolites that go unmeasured that are responsible for the observed response. For example, Acacia angustissima is a legume that produces a moderate concentration of CT (7-9% DM) and suppresses ruminal methane production (Naumann et al, 2013b), binds protein (Naumann et al, 2014b), and inhibits larval migration of L3 Haemonchus contortus (Naumann et al, 2014a). Condensed tannins may be the only one, of the many plant specialized metabolites found in A. angustissima, affecting these responses (McSweeney et al, 2008).…”

Section: The Anti-nutritional Effect Of Condensed Tanninsmentioning

confidence: 99%

“…A major challenge of using CT-containing plants as anthelmintics is that not all forages containing CT have anthelmintic properties (Naumann et al, 2014a). Condensed tannins from Leucaena retusa, Lespedeza stuevei, and Acacia angustissima var.…”

Section: The Anthelmintic Activity Of Condensed Tanninsmentioning

confidence: 99%

“…There is enough evidence that smaller CT polymers have greater anthelmintic activity than large CT polymers (Naumann et al, 2014a, Barrau et al, 2005. However, Quijada et al (2015) and Desrues et al (2016) reported the opposite effect and suggested that variation in results is likely due to differences and difficulties in extraction and purification of CT, as well as differences in modes of action of different CT on different gastrointestinal nematode parasites.…”

Section: The Anthelmintic Activity Of Condensed Tanninsmentioning

confidence: 99%

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The role of condensed tannins in ruminant animal production: advances, limitations and future directions

et al. 2017

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-Tannins represent one of the most abundant polyphenolic compounds in plants. Tannins exist as a multitude of chemically unique entities in nature. The most commonly occurring tannins are typically divided into two major classes based on chemical structure: hydrolysable (HT) or condensed tannins (CT). Hydrolysable tannins are esters of gallic or ellagic acid linked to a polyol core, typically glucose. Condensed tannins or proanthocyanidins consist of flavan-3-ol subunits linked together to form oligomers and polymers. Both HT and CT are defined as astringent, medium-to-high-molecular weight polyphenolic compounds that characteristically bind and precipitate soluble proteins. The objective of this paper was to present recent advances in CT-ruminant interactions, the limitations associated with understanding and using CT in ruminant animal production, and future needs for research to further advance our knowledge of the role of CT in optimization of ruminant animal production. Condensed tannins pose some anti-nutritional problems to ruminants due to their astringent property that reduces feed intake and, consequently, animal performance. Ruminants can, however, tolerate CT by slowly adapting the ruminal microbes to the toxic effects of CT and by releasing CT-binding salivary proteins. The protein-binding ability of CT has some benefits to the ruminant due to complexes formed with essential amino acids, preventing their degradation in the rumen, but releasing them in the lower gut for absorption by the animal. Recent data have suggested increased N retention when CT is given to growing animals. There are potential benefits of using CT and HT for anthelmintic purposes due to their ability to inhibit egg hatching and larval motility of gastrointestinal nematode parasites, especially in small ruminants. Condensed tannins also bind to minerals (Al, Ca, Co, Cu, Fe, Mg, Mn, P, and Zn). Although studies with ruminants have been contradictory, it has been reported that because the CT-metal ion complex is stable over a wide pH range, CT may reduce the bioavailability of minerals. Methane mitigation by feeding CT might be the most impactful benefit for ruminant production. Many empirical equations have been developed to predict ruminal methane emissions, but very few have included CT. Future research should focus on the improvement of methodology to assess CT biological activity, interaction with other plant-specialized metabolites, and associated physiological and nutritional impacts on ruminants.

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Section: The Anti-nutritional Effect Of Condensed Tanninsmentioning

confidence: 99%

Section: The Anthelmintic Activity Of Condensed Tanninsmentioning

confidence: 99%

Section: The Anthelmintic Activity Of Condensed Tanninsmentioning

confidence: 99%

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The role of condensed tannins in ruminant animal production: advances, limitations and future directions

et al. 2017

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“…Condensed tannins (CT) in the ground juniper were assayed for extractable, protein-bound, and fiber-bound fractions by methods described by Terrill et al (1992). Samples were oven dried and standards prepared as recommended by Wolfe et al (2008), using CT extracts purified on a Sephadex LH-20 (GE Healthcare Bio-Sciences Corp, Piscataway, NJ) and lyophilized to recover purified CT. Subsamples were also analyzed for protein precipitable phenolics (PPP; a measure of readily bioactive CT), amount of protein bound by CT per kg of juniper material (PB), and protein binding capacity of CT (PB/PPP; CT potency) according to procedures reported by Naumann et al (2014). Additional juniper subsamples, not mechanically dried, were steam distilled to determine total volatile oil yield as adapted by Koedam and Looman (1980) and Adams (1991).…”

Section: Chemical Analysesmentioning

confidence: 99%

Effects of feeding juniper as a roughage on feedlot performance, carcass measurements, meat sensory attributes, and volatile aroma compounds of yearling Rambouillet wethers1,2

Kerth

Wall

Miller

et al. 2019

Journal of Animal Science

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The majority of U.S. lambs are born during late winter or early spring, which can create downstream variability in carcass quality if commercial lamb harvest is to be relatively constant throughout the year. Flavor is an important quality determining characteristic of sheep meat and is influenced, in part, by animal age at harvest. However, management practices to mitigate the risk of objectionable flavors in meat from old crop lambs or yearlings are not well known. Yearling (16.8 ± 0.14 mo) Rambouillet wethers were assigned to 1 of 3 treatment groups, which consisted of feeding a 20% ground sorghum-sudangrass hay diet for 40 d (JUN0; n = 10), a 20% ground juniper diet for 40 d (JUN40; n = 10), or a 20% ground hay diet for 20 d followed by a 20% ground juniper diet for 20 d (JUN20; n = 10). Wethers were harvested on day 41 and a whole bone-in loin and a boneless inside leg roast were fabricated from one side each of carcass. After grilling (loin chop) or convection air roasting (leg roast), trained sensory panel evaluation and measurement of aroma volatiles by gas chromatography/mass spectrometry were performed. Treatment diet did not affect (P ≥ 0.17) wether feedlot performance, dressing percentage, or loin eye area. However, wethers fed JUN0 tended (P = 0.06) to have greater back fat depth than wethers fed JUN20 or JUN40. No trained sensory panel trait of loin chop samples was affected (P > 0.10) by treatment. Leg roasts from JUN0 and JUN20 wethers had greater (P = 0.01) lamb identification sensory score than JUN40. Benzaldehyde, 1-heptanol, and 1-octanol concentrations were greater (P < 0.05) and decanal and nonenal concentrations were less (P < 0.05) in loin chops from JUN0 compared with JUN40 wethers. Additionally, the terpenes cedr-8-ene, gamma muurolene, and widdrene tended to be greater (P < 0.07) in loin chops from JUN20 and JUN40 than JUN0 wethers. The 2-pentyl-furan concentrations were greatest (P = 0.03) in leg roasts from JUN40 wethers. Like the loin chops, cedr-8-ene, gamma-muurolene, toluene, and widdrene were greater (P < 0.05) in leg roasts from wethers fed either of the juniper diets compared with JUN0. Yearling wethers can be finished on a feedlot diet containing 20% juniper for up to 40 d prior to harvest with no impact on feedlot performance, carcass characteristics, nor negative impact on sensory attributes or volatile compounds of either grilled loin chops or roasted legs.

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“…It has also endocrine, relaxing effects and reduces inflammation (Al-Snafi 2014). Some studies have showed inhibitory activity of legumes against larvae and adult motility of H. contortus (Naumann et al, 2014;Von Son-de Fernex et al, 2012). Current study has been planned to test the anthelmintic efficacy of Arachis hypogaea (peanut) peels against the eggs, larvae and adult forms of Haemonchus contortus.…”

Section: Introductionmentioning

confidence: 99%

In-vitro efficacy of Arachis hypogaea (Peanut) peels extract against Haemonchus contortus

Tahir¹,

Akhtar²,

Lateef³

et al. 2020

J Hellenic Vet Med Soc

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Synthetic anthelmintics are becoming ineffective due to development of parasitic resistance. For this reason, traditional medicinal plants are being explored for their anthelmintic potential. The aim of this study was to evaluate the in-vitro anthelmintic activity of Arachis hypogaea L. (peanut) peels against Haemonchus contortus. To assess the anthelmintic effect of Arachis hypogaea L. on 3 life cycles of Haemonchus contortus, egg hatch assay (EHA), larval developmental assay (LDA) and adult motility assay (AMA) were conducted. In these tests, methanol and n-hexane extracts of the plant were used in three concentrations of 10, 15 and 20 mg/ml. Levamisole and PBS were used as positive and negative control groups respectively. Results of these tests showed that methanol extract of Arachis hypogaea L. had higher anthelmintic effect than that of n-hexane extract. Overall both extracts exhibited a significant (p<0.05) dose and a time dependent anthelmintic effect. At 20 mg/ml, methanol extract and n-hexane extract showed 87% and 80% egg hatching inhibition respectively. Methanol and n-hexane extracts at 20 mg/ml showed 83.3% and 76.6% larval mortality respectively. Adult motility test with both extracts showed maximum immobilization of worms after 6 hours of treatment at 20 mg/ml concentration. It is concluded that peels of Arachis hypogaea possess significant anthelmintic potential against nematodes. It may be suggested that the plant can be used further to investigate the in-vivo activity.

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Effect of molecular weight and concentration of legume condensed tannins on in vitro larval migration inhibition of Haemonchus contortus

Cited by 25 publications

References 36 publications

The role of condensed tannins in ruminant animal production: advances, limitations and future directions

The role of condensed tannins in ruminant animal production: advances, limitations and future directions

Effects of feeding juniper as a roughage on feedlot performance, carcass measurements, meat sensory attributes, and volatile aroma compounds of yearling Rambouillet wethers1,2

In-vitro efficacy of Arachis hypogaea (Peanut) peels extract against Haemonchus contortus

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