Effect of Momordica charantia Seed Extracts on Ovarian and Uterine Activities in Albino Rats

Sharanabasappa, A; Vijayakumar, B.; Patil, Saraswati B.

doi:10.1076/phbi.40.7.501.14688

Cited by 28 publications

(20 citation statements)

References 14 publications

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“…The fruit and leaf of bitter melon have demonstrated an in vivo antifertility effect in female animals. Our earlier studies have reported the estrogenic and antiovulatory activities in female rats (Sharanabasappa & Saraswati, 2001;Sharanabasappa et al, 2002). The M. charantia is known for a variety of biological actions no systematic investigation for its male reproductive activities and toxicological studies has been done.…”

Section: Introductionmentioning

confidence: 99%

Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice

Patil

2011

Int. J. Morphol.

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Section: Introductionmentioning

confidence: 99%

Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice

Patil

2011

Int. J. Morphol.

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“…Bitter gourd has been used in traditional medicine to treat malaria, diabetes and other ailments, such as fevers, burns, skin problems and for birth control . Seed extracts of M. charantia reduce the number of ovarian follicles, alter normal oestrous cycles and inhibit pregnancy in female rats and mice . In rats, oral doses of petroleum ether, benzene, chloroform and ethanol extracts of seeds of M. charantia (250 mg kg −1 body weight) for 30 days induced irregular oestrous cycles, resulted in significant reductions in ovarian weight and numbers of developing follicles, Graafian follicles and corpora lutea and increased the number of atretic follicles .…”

Section: Plant Extracts With Effects On Ovarian Function Of Female Romentioning

confidence: 99%

“…Seed extracts of M. charantia reduce the number of ovarian follicles, alter normal oestrous cycles and inhibit pregnancy in female rats and mice . In rats, oral doses of petroleum ether, benzene, chloroform and ethanol extracts of seeds of M. charantia (250 mg kg −1 body weight) for 30 days induced irregular oestrous cycles, resulted in significant reductions in ovarian weight and numbers of developing follicles, Graafian follicles and corpora lutea and increased the number of atretic follicles . Two basic glycoproteins, alpha‐ and beta‐momorcharins isolated from M. charantia seeds, when given intraperitoneally to female mice, reduced the number of oocytes ovulated.…”

Section: Plant Extracts With Effects On Ovarian Function Of Female Romentioning

confidence: 99%

Fertility control of rodent pests: a review of the inhibitory effects of plant extracts on ovarian function

Tran

Hinds

2012

Pest Management Science

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Protection of plant extracts to prevent their degradation before uptake in the gastrointestinal tract could enhance short-term efficacy but would not enhance the longevity of their effects. Identification and further testing of the specific chemicals responsible for reproductive effects would be beneficial. The adoption of a standard protocol for treatment and assessment of the inhibitory effects of potential control agents on reproductive function in rodents is essential. Treatment with higher concentrations of extracts in conjunction with other extracts or with other chemosterilants could have potential complementary effects and lead to more rapid and permanent changes in ovarian function. An orally delivered agent(s) that causes major depletion of all follicle types, and particularly of non-regenerating primordial follicles, could be an ideal fertility control product and serve as an additional tool for population control of pest rodents.

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“…In our laboratory previous findings were reported on antiovulatory acivity on these plant extracts, they are Hibiscus rosa sinesis flowers 7 Momordica charantia seeds 8 Rivea hypocraterformis aerial parts 9 , Crotalaria juncea seeds 10, Citrus meidca seeds 11,12 and Oxalis corniculata whole plant 13 .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2016

IJPSR

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Present study was conducted to know the antifertility potential of Achyranthus aspera leaves in female mice and has shown promising results of antiovulatory activity, estrogenic and constant teratogenic activities. Administrations of A. aspera leaves methanolic extract at the dosage 25 mg/kg and 50 mg/kg body weight were subjected for testing their antiovulatory, estrogenic and teratogenic activity in female mice by applying statistical analysis in gravimetric, biochemical and histopathological parameters of ovary and uterus. At autopsy on day 31 st , both the dose treated mice revealed increase in ovarian weight, histological changes like increasing number of atretic follicle and decreases in healthy developing follicles, Graafian follicles and corpora lutea. Total cholesterol content and alkaline phosphatase of the ovary were increased and protein, glycogen, acid phosphatase content were decreased. Teratogenic activity did not alter any changes in the morphological and physiological behavior of experimental period. Results suggested that, methanolic extract of A. aspera leaves are more active at low dose compared to high dose and might be used as an herbal contraceptive in females.

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Effect of Momordica charantia Seed Extracts on Ovarian and Uterine Activities in Albino Rats

Cited by 28 publications

References 14 publications

Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice

Toxicological studies of Momordica charantia Linn Seed extracts in Male Mice

Fertility control of rodent pests: a review of the inhibitory effects of plant extracts on ovarian function

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