Effect of Montelukast sodium combined with Budesonide aerosol on airway function and T lymphocytes in asthmatic children

Jin, Wanqin; Zhao, Zichong; Zhou, Daohong

doi:10.12669/pjms.38.5.5749

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…1, the LAT values of the control group before and after treatment were (45.21±6.09 and 25.34±4.12) and the ODI 4 % values were (25.63±5. 19 Before treatment, there was no significant difference in LAT, ODI 4 % and AHI levels between the two groups (p>0.05). After treatment, the LAT, ODI 4 % and AHI levels of the observation group were significantly lower than those of the control group (p<0.05).…”

Section: Resultsmentioning

confidence: 80%

“…Studies have shown that the combination of these two drugs can have a synergistic effect, further improving the treatment effectiveness for children. Surgical treatment is achieved by removing enlarged lesions in children to improve clinical symptoms [19] . The traditional surgical methods for pediatric snoring are tonsillectomy and adenoidectomy, and the traditional surgical treatment effective rate can reach 85 % to 90 % [20] .…”

Section: Basic Data Informationmentioning

confidence: 99%

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Comparative Study of Montelukast and Mometasone Furoate in the Treatment of Pediatric Obstructive Sleep Apnea Syndrome

Xing,

Wu,

Zhu

et al. 2023

IJPS

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This study aimed to compare the efficacy of combined treatment with kenacort and montelukast vs. surgical treatment using low temperature plasma radiofrequency ablation in children with snoring. 70 children with snoring were selected as the study subjects at our hospital and all children met the inclusion criteria. According to the different treatments received by the children, the control group (n=35) received combined treatment with kenacort and montelukast, while the observation group (n=35) underwent surgery (low temperature plasma radiofrequency ablation). The clinical treatment effects, degree of adenoid hypertrophy, symptom improvement, ventilator function, sleep quality and quality of life were compared between the two groups of children. The total effective rate of treatment in the control group was 71.43 %, while that in the observation group was 94.29 %, which was significantly higher than that in the control group (p<0.05). Before treatment, there was no significant difference in the adenoid-nasopharyngeal ratio between the two groups (p>0.05). After treatment, the adenoidnasopharyngeal ratio in the observation group was significantly lower than that in the control group (p<0.05). Before treatment, there was no significant difference in the symptom score between the two groups (p>0.05). After treatment, the symptom score in the observation group was significantly lower than that in the control group (p<0.05). Before treatment, there was no significant difference in the LAT, oxygen desaturation index 4 % and apnea-hypopnea index levels between the two groups (p>0.05). After treatment, the LAT, oxygen desaturation index 4 % and apnea-hypopnea index levels in the observation group were significantly lower than those in the control group (p<0.05). Before treatment, there was no significant difference in the Pittsburgh sleep quality index score and obstructive sleep apnea-1 score between the two groups (p>0.05). After treatment, the Pittsburgh sleep quality index score and obstructive sleep apnea-1 score in the observation group were significantly lower than those in the control group (p<0.05). Compared with combined treatment with kenacort and montelukast, low-temperature plasma radiofrequency ablation is more effective for children with snoring and surgical treatment can better improve the clinical symptoms and ventilator function of children, thereby further improving their sleep quality and quality of life.

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Section: Resultsmentioning

confidence: 80%

Section: Basic Data Informationmentioning

confidence: 99%

Comparative Study of Montelukast and Mometasone Furoate in the Treatment of Pediatric Obstructive Sleep Apnea Syndrome

Xing,

Wu,

Zhu

et al. 2023

IJPS

View full text Add to dashboard Cite

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“…Montelukast sodium belongs to a type of leukotriene antagonist that is selective. [7][8][9] It can prevent leukotriene from attaching to receptors, thus regulating inflammation while compensating for budesonide's limitations. [10][11][12] Therefore, to further investigate the clinical therapeutic effect of budesonide combined with montelukast sodium in bronchial asthma, 86 children with bronchial asthma admitted to our hospital from January 2019 to December 2020 were selected for the following study and report.…”

Section: Introductionmentioning

confidence: 99%

Effect of budesonide combined with montelukast sodium on pulmonary function parameters and immunoglobulin levels in children with bronchial asthma

Chu

Liang

Chen

2023

Allergol Immunopathol

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Background and aim: Bronchial asthma is a prevalent type of respiratory disease that affects a large proportion of pediatric patients. The purpose of this study is to further investigate the clinical effects of budesonide combined with montelukast sodium in treating bronchial asthma. Methods: Eighty-six children with bronchial asthma were equally divided into study and control groups via randomized double-blind controlled trial. The control group was treated with aerosol inhalation of budesonide combined with placebo, while the study group was treated with budesonide combined with montelukast sodium. Pulmonary function parameters, immunoglobulin, and recovery of related symptoms, along with the adverse reaction rate, were observed and compared between both groups. Results: Before treatment, there was no marked difference in pulmonary function parameters and immunoglobulin indexes between both groups (P > 0.05). All pulmonary function indicators and immunoglobulin indexes in both groups improved following therapy, with the study group outperforming the control group (P < 0.05). The recovery time of related symptoms in the study group was shorter than that in the control group (P < 0.05). The incidence of adverse reactions in both groups was compared, with notable differences (P < 0.05). Conclusion: Budesonide combined with montelukast sodium in the treatment of bronchial asthma has the value of clinical application and promotion.

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Pediatric Asthma: Where Has Montelukast Gone?

et al. 2023

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At its introduction in the management of pediatric asthma, montelukast was regarded as a potentially revolutionary drug due to its mechanism of action and easy clinical applicability. Nevertheless, its use in daily practice and evidence from clinical trials have shown that, rather than a radical change in the approach to asthmatic children, montelukast more likely represents a second-line medication that is useful when inhaled steroids alone fail in providing adequate symptom control. Furthermore, increasingly reported side effects have raised concerns regarding its safety. In the last decade, several studies have tried to better define the strengths and drawbacks of montelukast both in preschool wheezing and school-age asthma. The present review summarizes the literature published on this topic since 2010, highlighting the often-controversial results and the unanswered questions regarding the role of montelukast in pediatric asthma. Moreover, advances in the understanding of the mechanisms of action of montelukast are reported. The main finding emerging from the present analysis is that montelukast application is likely to be useful in a subset of asthmatic children rather than in large groups of patients. Future studies should focus on the identification of biomarkers able to predict which patients will benefit from montelukast to achieve a more tailored prescription.

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Effect of Montelukast sodium combined with Budesonide aerosol on airway function and T lymphocytes in asthmatic children

Cited by 3 publications

References 17 publications

Comparative Study of Montelukast and Mometasone Furoate in the Treatment of Pediatric Obstructive Sleep Apnea Syndrome

Comparative Study of Montelukast and Mometasone Furoate in the Treatment of Pediatric Obstructive Sleep Apnea Syndrome

Effect of budesonide combined with montelukast sodium on pulmonary function parameters and immunoglobulin levels in children with bronchial asthma

Pediatric Asthma: Where Has Montelukast Gone?

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