Effect of Moxidectin Treatment at Peripartum on Gastrointestinal Parasite Infections in Ewes Raised under Tropical Andes High Altitude Conditions

Vargas-Duarte, JJ; Lozano-Márquez, Harvey; Grajales-Lombana, HA; Perdomo, Carlos Manrique; Martínez-Bello, DA; Saegerman, Claude; Raes, Marianne; Kirschvink, Nathalie

doi:10.1155/2015/932080

Cited by 3 publications

(2 citation statements)

References 43 publications

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“…This phenomenon is attributed to the reduction in the immune response of ewes against GIN infections during the lactation period (Beasley et al, 2010) because the nutrients redirection to milk production to feed their lambs (Houjdijk et al, 2008). The highest FEC excretion observed during early lactation matches the reports of Tembely et al (1998) and Vargas-Duarte et al (2015) regarding ewes examined during the postpartum period. During early lactation stage, the FEC showed their highest value and a slight increase in IgA values was observed (Table 1).…”

Section: Discussionsupporting

confidence: 86%

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Optimum timing for assessing phenotypic resistance against gastrointestinal nematodes in Pelibuey ewes

Zaragoza-Vera,

Gonzalez-Garduño,

Arjona-Jimenez

et al. 2023

Helminthologia

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Summary The objective was to identify the optimal stage of production to evaluate the resistance of Pelibuey ewes against gastrointestinal nematodes (GIN). Faecal egg count (FEC) was used to classify the ewes as resistant, sensible or intermediate against GIN. Forty-seven ewes were mating during 30 d. The gestation was verified by ultrasonography, and the breeding date was used to calculate the productive stages. Faeces were taken weekly to determine the FEC. Blood samples were taken to determine the packed cell volume (PCV), the peripheral eosinophils count (PEC), plasma protein concentration (PP), and Immunoglobulin A (IgA) against Haemonchus contortus. The body condition score (BCS) was recorded at each visit. Six moments during the study (early, mid and late gestation; early, mid and late lactation) were considered. The ewes were classified according to FEC (mean FEC ± three standard errors). The higher FEC occurred during all lactation stages than during early and mid-gestation stages (P<0.05). PCV, PP, and BCS during early gestation stage were higher than shown during the lactation stages (P<0.01). The PEC and IgA were higher during all lactation stages than early and mid-gestation stages (P<0.05). Concerning the type of birth, double births showed higher FEC than single birth (P<0.01). The highest values of accuracy (100 %) and concordance (Youden's J = 1.0) were found during early lactation. Therefore, it is concluded that the optimal stage of production to evaluate phenotypic resistance against GIN infections in Pelibuey ewes was during the early lactation.

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Section: Discussionsupporting

confidence: 86%

“…The highest FEC excretion observed during early lactation matches the reports of Tembely et al . (1998) and Vargas-Duarte et al . (2015) regarding ewes examined during the postpartum period.…”

Section: Discussionmentioning

confidence: 95%

Optimum timing for assessing phenotypic resistance against gastrointestinal nematodes in Pelibuey ewes

Zaragoza-Vera,

Gonzalez-Garduño,

Arjona-Jimenez

et al. 2023

Helminthologia

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Helminthiasis characterization and anthelmintic efficacy for ewes and lambs raised in tropical semiarid region

Bastos

Fonseca

Ferreira

et al. 2017

Trop Anim Health Prod

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In this study the helminthiasis and anthelmintic effectiveness in ewes and lambs were evaluated in a semiarid region of Brazil. Twelve sheep farms were investigated using semi-structured questionnaires and fecal egg count (FEC) reduction test was employed to analyze the profile of anthelmintic resistance. Groups of at least 10 animals with FEC ≥ 300 were selected. After 12 h of fasting, homogeneous groups of lambs or ewes were treated with albendazole, levamisole moxidectin, or oxfendazole and control groups were not treated. Feces were collected before treatments and 14 days after, and larvae genera were identified after cuprocultures in both periods. Extensive grazing was the predominant creation system, using hybrid Santa Ines animals. The separation by age was promoted in 75% of herds; however, maternity pickets there were only in three farms. The strategic treatments were performed only in 8.4% of sheep farms and 16.6% used the anthelmintic efficacy test and alternated anthelmintic classes after 1 year. The initial FEC means for lambs were significantly higher than ewe FEC averages. For lamb tests, moxidectin and levamisole showed higher efficacy (p ≤ 0.05) than benzimidazoles. For ewe tests, moxidectin and levamisole showed efficiencies >75%. Haemonchus spp. and Trichostrongylus spp. were the most frequent nematodes before treatments and the genus Haemonchus was the most prevalent after anthelmintic treatments (p < 0.05). Variations of anthelmintic susceptibility were observed for categories and herds evaluated, which emphasizes the importance of the effectiveness tests for the choice of anthelmintics for ewes and lambs.

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Physiological, immunological and genetic factors in the resistance and susceptibility to gastrointestinal nematodes of sheep in the peripartum period: A review

2021

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Summary Parasitic diseases of sheep involving gastrointestinal nematodes (GIN) are one of the main problems that affect fl ock productivity, especially during the peripartum period. Around lambing, the ewes are immunosuppressed and the nematode faecal egg count (FEC) increases at four weeks before lambing, reaching a peak between the fourth and sixth week postpartum and subsequently decreasing towards weaning. Prolactin has been credited with a suppressive effect on immune system, along with other hormones that intervene in metabolism, such as leptin, which has an important role in the activation of other hormones. Cortisol has also been included; this is stimulated by any stressful event and inhibits the proliferation of T-cells and alters the function of immunoglobulins. Another related hormone is pepsinogen, which is considered a marker of the integrity of the abomasum mucosa, as well as the albumin concentration that increases in the presence of a GIN infection. The humoral and cellular immune response, as well as inflammatory reactions, are the main mechanisms of action against GIN. Lymphocytes direct the effector mechanisms in a Th2 cell response, including interleukins (IL-4, IL-5, IL-9, IL-10) and transforming growth factor beta (TGF-β) together with immunoglobulins (IgA, IgG, IgM and IgE), which prevent the invasion of pathogens. Eosinophils with a cytotoxic effect are indicators of a parasitic infection, with importance in the immune protection of infected individuals. The genetic selection of resistant individuals measured by FEC is dependent on the heritability (h2), which is moderately inheritable and highly repeatable. Effects that influence the resistance or susceptibility of sheep to GIN infections in the peripartum period are determined by the interaction of various factors, such as genotype or breed, nutrition, age, type of birth, season and production system, etc., which are studied in this review.

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Effect of Moxidectin Treatment at Peripartum on Gastrointestinal Parasite Infections in Ewes Raised under Tropical Andes High Altitude Conditions

Cited by 3 publications

References 43 publications

Optimum timing for assessing phenotypic resistance against gastrointestinal nematodes in Pelibuey ewes

Optimum timing for assessing phenotypic resistance against gastrointestinal nematodes in Pelibuey ewes

Helminthiasis characterization and anthelmintic efficacy for ewes and lambs raised in tropical semiarid region

Physiological, immunological and genetic factors in the resistance and susceptibility to gastrointestinal nematodes of sheep in the peripartum period: A review

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