Effect of multi-functional polyhydroxylated polyhedral oligomeric silsesquioxane (POSS) nanoparticles on the angiogenesis and exosome biogenesis in human umbilical vein endothelial cells (HUVECs)

Feghhi, Maryam; Rezaie, Jafar; Akbari, Ali; Jabbari, Nasrollah; Jafari, Hessam; Seidi, Farzad; Szafert, Sławomir

doi:10.1016/j.matdes.2020.109227

Cited by 46 publications

(28 citation statements)

References 65 publications

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“…Regarding the physicochemical characteristics of NMs, 78% of studies used nanoparticles of different chemical compositions as test substances (e.g., metallic, polymeric, metallic oxides, inorganic, etc.) [ 24 , 40 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ]. The remaining studies used nanotubes, nanoclusters, nanosheets, as well as dendrimers [ 26 , 49 , 50 , 51 ].…”

Section: Resultsmentioning

confidence: 99%

“…Interestingly, the impact of NMs on EV biogenesis is evident. Among the eighteen articles, fourteen studies showed that NMs increased EV secretion, especially for studies specifically referring to exosomes [ 20 , 24 , 26 , 40 , 41 , 42 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 ]. Twelve studies explored EV-enriched biomarkers (with CD81, CD63, CD9, and TSG101 being the predominantly analyzed markers), while three studies analyzed additional non-EV markers (GAPDH, Calnexin, and Calreticulin) [ 40 , 43 , 48 ].…”

Section: Resultsmentioning

confidence: 99%

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Nanomaterial Exposure, Extracellular Vesicle Biogenesis and Adverse Cellular Outcomes: A Scoping Review

et al. 2022

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The progressively increasing use of nanomaterials (NMs) has awakened issues related to nanosafety and its potential toxic effects on human health. Emerging studies suggest that NMs alter cell communication by reshaping and altering the secretion of extracellular vesicles (EVs), leading to dysfunction in recipient cells. However, there is limited understanding of how the physicochemical characteristics of NMs alter the EV content and their consequent physiological functions. Therefore, this review explored the relevance of EVs in the nanotoxicology field. The current state of the art on how EVs are modulated by NM exposure and the possible regulation and modulation of signaling pathways and physiological responses were assessed in detail. This review followed the manual for reviewers produced by The Joanna Brigs Institute for Scoping Reviews and the PRISMA extension for Scoping Reviews (PRISMA-ScR): checklist and explanation. The research question, “Do NMs modulate cellular responses mediated by EVs?” was analyzed following the PECO model (P (Population) = EVs, E (Exposure) = NMs, C (Comparator) = EVs without exposure to NMs, O (Outcome) = Cellular responses/change in EVs) to help methodologically assess the association between exposure and outcome. For each theme in the PECO acronym, keywords were defined, organized, and researched in PubMed, Science Direct, Scopus, Web of Science, EMBASE, and Cochrane databases, up to 30 September 2021. In vitro, in vivo, ex vivo, and clinical studies that analyzed the effect of NMs on EV biogenesis, cargo, and cellular responses were included in the analysis. The methodological quality assessment was conducted using the ToxRTool, ARRIVE guideline, Newcastle Ottawa and the EV-TRACK platform. The search in the referred databases identified 2944 articles. After applying the eligibility criteria and two-step screening, 18 articles were included in the final review. We observed that depending on the concentration and physicochemical characteristics, specific NMs promote a significant increase in EV secretion as well as changes in their cargo, especially regarding the expression of proteins and miRNAs, which, in turn, were involved in biological processes that included cell communication, angiogenesis, and activation of the immune response, etc. Although further studies are necessary, this work suggests that molecular investigations on EVs induced by NM exposure may become a potential tool for toxicological studies since they are widely accessible biomarkers that may form a bridge between NM exposure and the cellular response and pathological outcome.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Nanomaterial Exposure, Extracellular Vesicle Biogenesis and Adverse Cellular Outcomes: A Scoping Review

et al. 2022

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“…With their unique size and solubility properties, POSS molecules have numerous applications in material science [3] and biomedical engineering [4] because they serve as a foundation for the construction of more complex nanomaterials and surfaces [5–8] . The development of nanocomposite POSS copolymers towards applications includes aerospace materials, [9, 10] tissue scaffolds for wound healing, [11, 12] drug delivery systems, [13, 14] dental composites, [15, 16] and sensors [17] . The incorporation of POSS building blocks in these materials and their arising novel properties have been well investigated [18–20] .…”

Section: Figurementioning

confidence: 99%

Synthesis of Functionalized Silsesquioxane Nanomaterials by Rhodium‐Catalyzed Carbene Insertion into Si−H Bonds

2021

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We report carbene insertion into Si−H bonds of polyhedral oligomeric silsesquioxanes (POSS) for the synthesis of highly functionalized siloxane nanomaterials. Dirhodium(II) carboxylates catalyze insertion of aryl‐diazoacetates as carbene precursors to afford POSS structures containing both ester and aryl groups as orthogonal functional handles for further derivatization of POSS materials. Four diverse and structurally varied silsesquioxane core scaffolds with one, three, or eight Si−H bonds were evaluated with diazo reactants to produce a total of 20 new POSS compounds. Novel diazo compounds containing a fluorinated octyl group and boron‐dipyrromethene (BODIPY) chromophore demonstrate the use of highly functionalized substrates. Transformations of aryl(ester)‐functionalized POSS compounds derived from this method are demonstrated, including ester hydrolysis and Suzuki–Miyaura cross‐coupling.

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“…The organic moieties direct the functionalisation and reactivity of Tn compounds, and enable the cages to be modified by a palette of reaction including metathesis, [6][7][8] Heck coupling, 9,10 hydrosilylation, 11 thiol-ene click [12][13][14] or polymerisation. [15][16][17][18] A diverse range of applications for Tn cage systems have now been investigated, including bio/nanomedicine, [19][20][21][22][23][24][25] catalysis, [26][27][28][29] optoelectronics, 30 polymer chemistry, [31][32][33] and optical and sensing applications. [33][34][35][36] Postfunctionalised Tn compounds have also been incorporated into self-organised systems, [37][38][39][40][41] organic polymer-based nanohybrids, 31,33,[42][43][44][45] POSS micelles and templated POSS systems leading to mesoporous materials with embedded T8 cages.…”

Section: Introductionmentioning

confidence: 99%

Post-synthesis modification of functionalised polyhedral oligomeric silsesquioxanes with encapsulated fluoride – enhancing reactivity of T₈-F POSS for materials synthesis

et al. 2021

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Effect of multi-functional polyhydroxylated polyhedral oligomeric silsesquioxane (POSS) nanoparticles on the angiogenesis and exosome biogenesis in human umbilical vein endothelial cells (HUVECs)

Cited by 46 publications

References 65 publications

Nanomaterial Exposure, Extracellular Vesicle Biogenesis and Adverse Cellular Outcomes: A Scoping Review

Nanomaterial Exposure, Extracellular Vesicle Biogenesis and Adverse Cellular Outcomes: A Scoping Review

Synthesis of Functionalized Silsesquioxane Nanomaterials by Rhodium‐Catalyzed Carbene Insertion into Si−H Bonds

Post-synthesis modification of functionalised polyhedral oligomeric silsesquioxanes with encapsulated fluoride – enhancing reactivity of T₈-F POSS for materials synthesis

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Effect of multi-functional polyhydroxylated polyhedral oligomeric silsesquioxane (POSS) nanoparticles on the angiogenesis and exosome biogenesis in human umbilical vein endothelial cells (HUVECs)

Cited by 46 publications

References 65 publications

Nanomaterial Exposure, Extracellular Vesicle Biogenesis and Adverse Cellular Outcomes: A Scoping Review

Nanomaterial Exposure, Extracellular Vesicle Biogenesis and Adverse Cellular Outcomes: A Scoping Review

Synthesis of Functionalized Silsesquioxane Nanomaterials by Rhodium‐Catalyzed Carbene Insertion into Si−H Bonds

Post-synthesis modification of functionalised polyhedral oligomeric silsesquioxanes with encapsulated fluoride – enhancing reactivity of T8-F POSS for materials synthesis

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Post-synthesis modification of functionalised polyhedral oligomeric silsesquioxanes with encapsulated fluoride – enhancing reactivity of T₈-F POSS for materials synthesis